DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lip2 and Lipm

DIOPT Version :9

Sequence 1:	NP_524667.1	Gene:	Lip2 / 43980	FlyBaseID:	FBgn0024740	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_220066.4	Gene:	Lipm / 309528	RGDID:	1304912	Length:	422	Species:	Rattus norvegicus

Alignment Length:	433	Identity:	113/433 - (26%)
Similarity:	197/433 - (45%)	Gaps:	73/433 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VMLIVCAIGRNAHS-------SPPESRYKWTTMDWLEAQNVSH---------EVHNVTTADGYQL 60
            ::|:...:.||.:|       :.||:           ..|||.         |.:.|.|.|||.|
  Rat    20 LILVAYLLQRNVNSGHMPTKAADPEA-----------FMNVSEIIKHKGYPSEEYEVATEDGYIL 73

  Fly    61 QLQRLPR-------LGAKP-VLLVHGLLGSSLGWVCMGPERSLAFQLHHREYDVWLANLRGVSPY 117
            .:.|:||       .|::| |||.|||||.:..|:...|..||.|.|....:|||:.|.|| :.:
  Rat    74 SVNRIPRGQTQLKKEGSRPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWMGNSRG-NTW 137

  Fly   118 GRQHIDLTDVMVEFWRFSFHEHGAYDLPAIIDHMAKVTGGEQLASRGGPGQDEEQIHHQVVLIGH 182
            .|:|..|:....|||.||:.|...:||||:|:.:.:.||             :::|::    :|:
  Rat   138 SRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTG-------------QKKIYY----VGY 185

  Fly   183 SQAFNAFLVLCAVHPRFNQRIQLIQALAPLARL-HRQVRFDSFQV--RRLMKFIKKRQKAYKFEI 244
            ||......:..:..|....:|::..||||:|.: |.:.....|.:  ..::|.:..||:.    :
  Rat   186 SQGTTMGFIAFSTMPELAHKIKMYFALAPIATVKHAKSPGTKFLLLPDMMIKGLFGRQEF----L 246

  Fly   245 FPPGYFRK----VC-QAKRD-LCEYYAKQLVGSAQNNKKLLEAFNY-EYLLQGGSPREIKHLQQI 302
            :...:||:    :| |...| :|......|.|...||..:..|..| .:...|.|.:.|.|..|.
  Rat   247 YQTRFFRQLFIYLCGQMILDQICSNIILLLGGFNTNNMNMSRANVYVAHTPAGTSVQNILHWSQA 311

  Fly   303 WKSGDFISYDFGT-AENLQVYHSVEALSYNISQITVPIILYFGETDAIATPEGVHAIYARMLRSV 366
            ..||:..::|:|: .:|.:..:....:.|.:..:.||..::.|..|.::.|:.|..:.:.:   .
  Rat   312 VNSGELRAFDWGSETKNREKSNQPTPIRYKVRDMMVPTAMWTGGQDWLSNPDDVKTLLSEV---T 373

  Fly   367 KSVRRINSKKFNHLDFLISGDVKSLVNDKLIEHMEQFFDGRLP 409
            ..:...|..::.|:||:...|....|.:::|..|:|  :..||
  Rat   374 NLIYHKNIPEWAHVDFIWGLDAPHRVYNEIIHLMKQ--ESSLP 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip2	NP_524667.1	PLN02872	24..407	CDD:215470	108/417 (26%)
Lip2	NP_524667.1	Abhydro_lipase	48..90	CDD:282003	21/49 (43%)
Lipm	XP_220066.4	Abhydro_lipase	49..111	CDD:282003	23/61 (38%)
		Abhydrolase_1	92..392	CDD:278959	86/324 (27%)
		Abhydrolase_5	93..>231	CDD:289465	49/155 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335532
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860