DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and ARHGEF6

DIOPT Version :10

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_016885464.1 Gene:ARHGEF6 / 9459 HGNCID:685 Length:807 Species:Homo sapiens


Alignment Length:997 Identity:196/997 - (19%)
Similarity:350/997 - (35%) Gaps:326/997 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1054 EAFLKA--------CTLARR----TAETFLKYANRSQQCY--QYKGNCEGHVKSKLDKLLTQENQ 1104
            |.|||:        |.|..|    :.|.|         |.  |.:.:|..::...|....|.:.:
Human    28 EEFLKSSLKNGVVLCKLINRLMPGSVEKF---------CLDPQTEADCINNINDFLKGCATLQVE 83

  Fly  1105 VLD----------------YWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGE-----AYLSSRS 1148
            :.|                ...:.|.:.||..:......|:..|.    ||.:     |..|:.|
Human    84 IFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCGRSSSLSAA----NTSQTNPQGAVSSTVS 144

  Fly  1149 NLVGISK--EETEG-----LLKEHNEFRSTAKETRERVKLLIQLADSL----VEKGHAHASDIKQ 1202
            .|...||  |.||.     ::|....|:.|.::     :|.:...|.:    ||:|       ..
Human   145 GLQRQSKTVEMTENGSHQLIVKARFNFKQTNED-----ELSVCKGDIIYVTRVEEG-------GW 197

  Fly  1203 WVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNSSN 1267
            |..:::.|...|.:   :|..:::.|.|:|  .||.|.:.|.:||:     |.:..|.......:
Human   198 WEGTLNGRTGWFPS---NYVREIKSSDGVS--LLLPGLECNGAISA-----HHNLCLPGSKRPLS 252

  Fly  1268 KENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDVIFG 1332
            .:..:..|....:......::..::.||:.|..:|.:.:..:|...::..::.:..:..   :.|
Human   253 PKAVKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTS---LLG 314

  Fly  1333 NIKEIHHFHQKIFLRELEKYETMPED---VGHCFVTWASKF-DMYVHYCKNKPTSNNLLVQHGGS 1393
            |.:|:..|.|.: .:.||:....||:   ||.|.::....| .||:.||.|.|::.|:|.||.  
Human   315 NFEEVCTFQQTL-CQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHS-- 376

  Fly  1394 FFEELQRRLE---VDHP----LPAYLIKPVQRITKYQLLLKDLLSCCEESHGEIKEGLEVMLNVP 1451
              :||::.:|   ...|    |...|.||..|:.||..||::|....|::|.:.::.|:.::   
Human   377 --DELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIV--- 436

  Fly  1452 KKANDAMHLSLLENC-DVSVDKLGEV-VLQDAFQAWDTKQIIRKG------------------RE 1496
                  ...:|:..| |:...|..|: :|.:..|||:.:.|...|                  .|
Human   437 ------AFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEE 495

  Fly  1497 RRVFLFELYLLFAKEVKESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTGRSPMLSDCRIVL 1561
            |.:.||...|:........:...||.|..:..|.:...:.|||::..|.: ||.:..    |||:
Human   496 RYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEI-TGNTVE----RIVV 555

  Fly  1562 KATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDLDEQLTENDHDRCSLAS 1626
            ...:.:..|.|:::|..::             :.||..|..|:.||            ..||   
Human   556 HCNNNQDFQEWLEQLNRLI-------------RGPASCSSLSKTSS------------SSCS--- 592

  Fly  1627 FGSGNTTDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHD 1691
                                      |.|..::...|.||....:|||...:|            
Human   593 --------------------------AHSTFSQSFSSTGQPRGPLEPPQIIKP------------ 619

  Fly  1692 DAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSG 1756
                    ..:|.|:|.|...          .|:|...|..|        :..|..|:|    |.
Human   620 --------WSLSCLRPAPPLR----------PSAALGYKERM--------SYILKESSK----SP 654

  Fly  1757 RNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQPGASPATVLPSSQFPSST 1821
            :.....::::.|::.||.:..|.:.|...|                                   
Human   655 KTMKKFLHKRKTERKPSEEEYVIRKSTAAL----------------------------------- 684

  Fly  1822 QHPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIANGPPAFAKDAKESSGNMASPGKMDGNP--- 1883
                       |.|.::       :|.|:          |:...|....|:.:|..| |..|   
Human   685 -----------EEDAQI-------LKVIE----------AYCTSANFQQGHGSSTRK-DSIPQVL 720

  Fly  1884 LSEIEEIVKTTTEQHESNSRVDGGGGVENASTNGHGRSHDNN-DESHTAVSDKAAALKK-----R 1942
            |.|.|:::                  :|...:||.....:.: .::..|:.|:...||:     :
Human   721 LPEEEKLI------------------IEETRSNGQTIMEEKSLVDTVYALKDEVRELKQENKRMK 767

  Fly  1943 QCVFAELMSTEEAYVQDLHEIV 1964
            ||:..||.|.     :||.::|
Human   768 QCLEEELKSR-----RDLEKLV 784

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103 17/94 (18%)
SPEC 1125..1226 CDD:197544 25/116 (22%)
RhoGEF 1287..1455 CDD:459876 45/178 (25%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 32/141 (23%)
SH3_Kalirin_1 1643..1707 CDD:212786 11/63 (17%)
RhoGEF 1945..2121 CDD:459876 6/20 (30%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
ARHGEF6XP_016885464.1 CH_alphaPIX 1..117 CDD:409114 18/97 (19%)
RhoGEF67_u1 115..160 CDD:465201 13/48 (27%)
SH3_alphaPIX 162..219 CDD:212993 12/71 (17%)
RhoGEF 269..446 CDD:238091 46/193 (24%)
PH_Cool_Pix 477..574 CDD:269932 21/101 (21%)
RhoGEF67_u2 607..705 CDD:465200 28/202 (14%)
betaPIX_CC 716..800 CDD:465158 19/92 (21%)
Blue background indicates that the domain is not in the aligned region.

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