Protein Alignment trio and SESTD1

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_047302229.1
• Gene: SESTD1 / 91404
• HGNCID: 18379
• Length: 706
• Species: Homo sapiens
• Alignment Length: 801
• Identity: 178/801 - (22%)
• Similarity: 326/801 - (40%)
• Gaps: 165/801 - (20%)

  Fly     9 LLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNLGFTVIID 73
            :|.:|::::.||:||:|||.|.:|..|....:..:  ::|...|.||:||||:..|..|||||:|
Human    16 ILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNM--DELSVTLDYLLSIPSEKCKARGFTVIVD 78

  Fly    74 MRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKYK----FETTTVSIES 134
              |..:....|||::.:||....|.:..|.::|||.||.|:.......|.|    ||...||...
Human    79 --GRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANK 141

  Fly   135 LNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDVPLA 199
            |.:.:|..|||.||.|...|||..|.:.||..|.|..::..:.|                ::.|.
Human   142 LTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLD----------------ELALI 190

  Fly   200 RHAIDHHNEMRKK----ITKLPIEDLD---MQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSS 257
            .:..|..|:..|:    :..||..|.:   ..|.:||:::.       |...|.....:...|..
Human   191 NNGSDKGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQ-------QRRFNGSDGGVSWSPMD 248

  Fly   258 AGQQSQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDC 322
            ....:||.               |.|.|..:...:|..:::.. .:.|:.:|::      .:|..
Human   249 DELLAQPQ---------------VMKLLDSLREQYTRYQEVCR-QRSKRTQLEE------IQQKV 291

  Fly   323 EKMFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMN---VSVNIDRILAVAARLIES 384
            .::.:|:.........:...||.:...:::||.:|::  :.|.:   .:|.::....:||.|...
Human   292 MQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEE--IESQHSEWFAVYVELNQQIAALLNAG 354

  Fly   385 QHYAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAE-----------QYCNSVASWA 438
            .......:|:|.|:|.......|:.|:.|..:||.::.||..|:           ..|..||
Human   355 DEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVA--- 416

  Fly   439 AACQASQPLPSDIQSLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPD 503
                     |:|..|::..::..:...:::......:....:.||.|:
Human   417 ---------PADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQI----------------- 455

  Fly   504 HRKNSNNGSFNKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQE 568
              .|..:.::.|    :...:..|...|:..|:..:....:..|......||::.|.:.|...:|
Human   456 --SNQASWAYGK----DVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEE 514

  Fly   569 DVKQVLDWLKNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELAR-- 631
            |..|.::||....:..|:.:..:|.:..:.:|....|..|.:|||:||...::||.|...|.:
Human   515 DAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSL 579

  Fly   632 ------SGEADP--NEIYSVARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTD 688
                  ||:..|  |.::.          .|....|:|..||:||:.|:::.:
Human   580 RCTSRSSGDTLPRLNRVWK----------QFTIASEERVHRLEMAIAFHSNAE------------ 622

  Fly   689 VSTDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQEMR-SLEYADNT----GS 748
                  ::.|:..|..|.|..:.|.|:.|          :.|::||..:. .:.|.|.|    ||
Human   623 ------KILQDCPEEPEAINDEEQFDEIE----------AVGKSLLDRLTVPVVYPDGTEQYFGS 671

  Fly   749 IAALEATLEKLNKQKVELEEL 769
            .:.:.:|.|.: :.:::|..|
Human   672 PSDMASTAENI-RDRMKLVNL 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706	54/142 (38%)
		SPEC	314..>468	CDD:238103	30/167 (18%)
		SPEC	563..778	CDD:238103	51/222 (23%)
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1455	CDD:459876
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2121	CDD:459876
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
SESTD1	XP_047302229.1	CRAL_TRIO_2	43..163	CDD:463965	44/123 (36%)
		SPEC	283..488	CDD:413338	39/247 (16%)
		SPEC	423..615	CDD:413338	42/224 (19%)