DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and SESTD1

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_835224.3 Gene:SESTD1 / 91404 HGNCID:18379 Length:696 Species:Homo sapiens


Alignment Length:801 Identity:178/801 - (22%)
Similarity:326/801 - (40%) Gaps:165/801 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNLGFTVIID 73
            :|.:|::::.||:||:|||.|.:|..|....:..:  ::|...|.||:||||:..|..|||||:|
Human     6 ILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNM--DELSVTLDYLLSIPSEKCKARGFTVIVD 68

  Fly    74 MRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKYK----FETTTVSIES 134
              |..:....|||::.:||....|.:..|.::|||.||.|:.......|.|    ||...||...
Human    69 --GRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANK 131

  Fly   135 LNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDVPLA 199
            |.:.:|..|||.||.|...|||..|.:.||..|.|..::..:.|                ::.|.
Human   132 LTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLD----------------ELALI 180

  Fly   200 RHAIDHHNEMRKK----ITKLPIEDLD---MQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSS 257
            .:..|..|:..|:    :..||..|.:   ..|.:||:::.       |...|.....:...|..
Human   181 NNGSDKGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQ-------QRRFNGSDGGVSWSPMD 238

  Fly   258 AGQQSQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDC 322
            ....:||.               |.|.|..:...:|..:::.. .:.|:.:|::      .:|..
Human   239 DELLAQPQ---------------VMKLLDSLREQYTRYQEVCR-QRSKRTQLEE------IQQKV 281

  Fly   323 EKMFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMN---VSVNIDRILAVAARLIES 384
            .::.:|:.........:...||.:...:::||.:|::  :.|.:   .:|.::....:||.|...
Human   282 MQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEE--IESQHSEWFAVYVELNQQIAALLNAG 344

  Fly   385 QHYAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAE-----------QYCNSVASWA 438
            .......:|:|.|:|.......|:.|:.|..:||.::.||..|:           ..|..||   
Human   345 DEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVA--- 406

  Fly   439 AACQASQPLPSDIQSLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPD 503
                     |:|..|::..::..:...:::......:....:.||.|:                 
Human   407 ---------PADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQI----------------- 445

  Fly   504 HRKNSNNGSFNKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQE 568
              .|..:.::.|    :...:..|...|:..|:..:....:..|......||::.|.:.|...:|
Human   446 --SNQASWAYGK----DVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEE 504

  Fly   569 DVKQVLDWLKNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELAR-- 631
            |..|.::||....:..|:.:..:|.:..:.:|....|..|.:|||:||...::||.|...|.:  
Human   505 DAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSL 569

  Fly   632 ------SGEADP--NEIYSVARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTD 688
                  ||:..|  |.::.          .|....|:|..||:||:.|:::.:            
Human   570 RCTSRSSGDTLPRLNRVWK----------QFTIASEERVHRLEMAIAFHSNAE------------ 612

  Fly   689 VSTDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQEMR-SLEYADNT----GS 748
                  ::.|:..|..|.|..:.|.|:.|          :.|::||..:. .:.|.|.|    ||
Human   613 ------KILQDCPEEPEAINDEEQFDEIE----------AVGKSLLDRLTVPVVYPDGTEQYFGS 661

  Fly   749 IAALEATLEKLNKQKVELEEL 769
            .:.:.:|.|.: :.:::|..|
Human   662 PSDMASTAENI-RDRMKLVNL 681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706 54/142 (38%)
SPEC 314..>468 CDD:238103 30/167 (18%)
SPEC 563..778 CDD:238103 51/222 (23%)
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1456 CDD:279015
PH1_Kalirin_Trio_like 1462..1584 CDD:270060
PH 1495..1580 CDD:278594
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
SESTD1NP_835224.3 CRAL_TRIO_2 33..153 CDD:404584 44/123 (36%)
SPEC 273..478 CDD:413338 39/247 (16%)
Spectrin 1 275..378 19/110 (17%)
Spectrin 2 381..494 20/147 (14%)
SPEC 413..605 CDD:413338 42/224 (19%)
Spectrin 3 500..602 27/111 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 64 1.000 Domainoid score I10207
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.