DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trio and KALRN

DIOPT Version :9

Sequence 1:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster
Sequence 2:	XP_006713873.1	Gene:	KALRN / 8997	HGNCID:	4814	Length:	2988	Species:	Homo sapiens

Alignment Length:	2351	Identity:	1014/2351 - (43%)
Similarity:	1466/2351 - (62%)	Gaps:	223/2351 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DGQRARDLLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNL 66
            ||.:|.|:|.:|:|:|.|::||||:||||:|.|||....||::.||||:|::||.|:||:.....
Human    30 DGLKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKR 94

  Fly    67 GFTVIIDMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKYKFETTTVS 131
            ||||||||||:.  ...:|.:||.|||.|.|.||..:|||||||||||:.:..|.|:.|||:.||
Human    95 GFTVIIDMRGSK--WDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVS 157

  Fly   132 IESLNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDV 196
            :|.|.|:|:..|||.:|:|...|:|::|.:.||::|:||..|..:..|::||||.|.|.:|..||
Human   158 VEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDV 222

  Fly   197 PLARHAIDHHNEMRKKITKLPIEDLDMQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSAGQQ 261
            ..:|..||.|.:::||:.|.|:|:||.:|::||..|..           |.|        .:|:.
Human   223 EGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRC-----------SDG--------FSGRN 268

  Fly   262 SQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEKMF 326
            ..|        |:.|..:.|.|....::.:|:.::.|..:|..:|:|||||||.||||||.||||
Human   269 CIP--------GSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMF 325

  Fly   327 DWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVAARLIESQHYAAQH 391
            |||.||:::|..|:.|||.:|..|..||.:|..||:.|||..|||:||::||:||.|:.|||:|.
Human   326 DWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQ 390

  Fly   392 IKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQPLPSDIQSLET 456
            ||.::.:||:.||.|||.||||:.:|.:|.:||.||||:.:.|.:|...| :...|||::|.||.
Human   391 IKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMC-SEGGLPSEMQDLEL 454

  Fly   457 AIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHRKNSNNGSFNKYERQNP 521
            ||..||:|||.:.||||||....|.||       .|..:|..||      ||        |....
Human   455 AIHHHQTLYEQVTQAYTEVSQDGKALL-------DVLQRPLSPG------NS--------ESLTA 498

  Fly   522 AADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQEDVKQVLDWLKNHGEVFLR 586
            .|:||:....||.|:|::|.|.|.||:.|...::||||.|.|.:||:||:|||||::||||.||.
Human   499 TANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLS 563

  Fly   587 KNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGEADPNEIYSVARELELQV 651
            |:||:|::.|:||..|..||:||.||||||:||.|||.||::||::||.||.|||..||.||:::
Human   564 KHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRI 628

  Fly   652 GSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQ 716
            ..|..|||||:..|||:|.|:||.|::..|::.|:.::..|   :..::::.::.:::|:|: ||
Human   629 QDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLED---VCADSVDAVQELIKQFQQ-QQ 689

  Fly   717 ESSVNVCLTTISQGEALLQEMRSL--------EYAD---------NTGSIAALEATLEKLNKQKV 764
            .::::..|..|.:||.|:|::||.        |..|         ::.||:.:|:.|::|:..:|
Human   690 TATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQV 754

  Fly   765 ELEELWSARKFRADLILRLRYFERDARLLSVQMEMWSEEL--QHADL-SRDYQKAEQLIRMHNES 826
            ::|||:..||.:.|:.|:||.||:....::.:::.|:|:|  |..|. :.|...|||.::.|.|.
Human   755 QMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTER 819

  Fly   827 VTEIQNATYEVVQQGQDLLQLF---ENAGFISMADATHTAQARIEYLLDFLREREIDLEEMSEAK 888
            ...:.|.|:||:||||||.|..   :.:|...:.:......|:::.||:||.|::.:||..:|..
Human   820 KLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQT 884

  Fly   889 RAKLEQAVQLCQFQNDANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIE------ 947
            ..:|||.:||...|.:..||:.||||||:||.||.|..:||.|||||::.|||||:|||
Human   885 HKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHAT 949

  Fly   948 ---KTHTSAVQVKYRADALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTA 1009
               |||.||:||:.:|:.|:.|.|||..:|.|.::.|...||||:...|:|.|||.||:.||||:
Human   950 SLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTS 1014

  Fly  1010 EQVCSVLDSLEREYKREDDWCDGGGGSDK------AQAIVQLISKHQEQKEAFLKACTLARRTAE 1068
            |||||||:|||:||:|::|||   ||.||      ...::.|||||.|||||||||||||||.||
Human  1015 EQVCSVLESLEQEYRRDEDWC---GGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAE 1076

  Fly  1069 TFLKYANRSQ----QCYQYKGNCEGHVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSA 1129
            .||||.:|:.    ....:....|..||:.|.:||.:||:||.:|||:|:.||||||:|:|||||
Human  1077 VFLKYIHRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSA 1141

  Fly  1130 KQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGH 1194
            |||::||..|||.|||:.:: .|.:.|||:.||||:.|||..||:|:|:||||||||||.|||||
Human  1142 KQALDWIQETGEFYLSTHTS-TGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGH 1205

  Fly  1195 AHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSS-----ISSSSGDRH 1254
            .||::|::||.:||:.|:|||.||..|...|||:||::       ::.|..     |.:|..||
Human  1206 IHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVN-------TEDNKDLELDIIPASLSDR- 1262

  Fly  1255 SDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAG-KS 1318
                 |.||..:   |.|:|||||||||:||||||||:|||:|||.||..|::.:|.|..:| :.
Human  1263 -----EVKLRDA---NHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEE 1319

  Fly  1319 VPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTS 1383
            :|..::.:|.:|||||:||:.||..|||:||||||.:||||||||||||.||.|||.||||||.|
Human  1320 IPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDS 1384

  Fly  1384 NNLLVQHGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEESHGEIKEGLEVML 1448
            |.|:::|.|:||:|:|:|..:.:.:.:|||||||||||||||||:||:||||..||:|:||||||
Human  1385 NQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKDGLEVML 1449

  Fly  1449 NVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVK 1513
            :||||||||||:|:||..|.::|..||::||||||.||.|.:|||||||.:||||:.|:|:||:|
Human  1450 SVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIK 1514

  Fly  1514 ESN-VVKYQFKSKLMTTDMGITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLR 1577
            :|: ..||.:|:||:|:::|:|||:|||..|||:|:||:|. ||.:.||||:::||||.|:|.:|
Human  1515 DSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPS-SDNKTVLKASNIETKQEWIKNIR 1578

  Fly  1578 EVMQETC--FSGT---SLTLPKSPAKHSGSSQRSS-RDLDEQLT-ENDHDRCSLASFGSGNTTDS 1635
            ||:||..  ..|.   .|.|||:|||...:|:|.. .|:|.|.. .:..|..|:||..|.||.||
Human  1579 EVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGDGSSQPDTISIASRTSQNTVDS 1643

  Fly  1636 DNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLV 1700
            |...|..|.|.|:.|:.| ..|:||::..||.||::|.|:. .|.:||||..   :.:...||||
Human  1644 DKLSGGCELTVVLQDFSA-GHSSELTIQVGQTVELLERPSE-RPGWCLVRTT---ERSPPLEGLV 1703

  Fly  1701 PVSVLKPPPGSHKHGS-----------GTAANAASSAGSQKSDMQDQSNRSKADALSSS--TKRR 1752
            |.|.|..   ||...|           ...::::|..|.:...:.:...:...:::.||  .||.
Human  1704 PSSALCI---SHSRSSVEMDCFFPLVKDAYSHSSSENGGKSESVANLQAQPSLNSIHSSPGPKRS 1765

  Fly  1753 GFSGRNWLPL-MNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQPGASPATVLPSSQ 1816
            ..:.:.||.. :.|..:.|...:   :||  :|.:|..:|.    .:..:.:||..   ..|..
Human  1766 TNTLKKWLTSPVRRLNSGKADGN---IKK--QKKVRDGRKS----FDLGSPKPGDE---TTPQG- 1817

  Fly  1817 FPSSTQHPGGAGAGDYEPDEEVGLELPPPMK-----PIQE---PHLIANGPPAFAKDAKESSGNM 1873
              .|.......|.|:.|||||....||||||     |.|:   ..|:|         |:::|..:
Human  1818 --DSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLLA---------ARQASTEV 1871

  Fly  1874 ASPGKMDGNPLSEIEEIVKTTTEQHESNSRVDGGGGVENASTNGHGR---SHDNNDESHTAVSDK 1935
            .:...:    ::.||::||.......|:.|   |...:.|.....|.   :...|.|.    ..|
Human  1872 PTAADL----VNAIEKLVKNKLSLEGSSYR---GSLKDPAGCLNEGMAPPTPPKNPEE----EQK 1925

  Fly  1936 AAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIY 2000
            |.||:.|..|..||:.||:.||:||..:|.|:|..|....    :|||:: ||.|:||.||..||
Human  1926 AKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKG----VPEDMR-GKDKIVFGNIHQIY 1985

  Fly  2001 EWHRDFFLRALRNCQKSPADLGPLIKRSATKFALYYTYCSNKPLSEYIVSAHYQYFDSIRQKLGH 2065
            :||:||||..|..|.:....|..|..:...|..:|..||.|||.|||||:.:..||:.::|::..
Human  1986 DWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQ 2050

  Fly  2066 RLDLSNLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVNDMMVVLRSL 2130
            ||.||:.:|||:||||||:||:|:.::.:|.|||  |...:::|.:.|.:|.|..||||.:.| |
Human  2051 RLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGL--ECSDIEKAVELMCLVPKRCNDMMNLGR-L 2112

  Fly  2131 QDFDGEITAQGSLLMQGPMNCV-VDAAQKHR--ELQVFLFQQIIIFADIEKTKNQYASPIFKYRS 2192
            |.|:|.:||||.||.|.....: :||..:.|  |.:||||:||:||:::  .:....:|.:.::.
Human  2113 QGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSEL--LRKGSLTPGYMFKR 2175

  Fly  2193 HIQLNHMQMKELGD---CRFQI--RSTDPKIPEMTIICQAASQENYAGWRDMLNKILQQQNDLIF 2252
            .|::|::.::|..|   |:|.:  |.|..:     ::.|||:.:....|...:|::|:.|.|.:.
Human  2176 SIKMNYLVLEENVDNDPCKFALMNRETSER-----VVLQAANADIQQAWVQDINQVLETQRDFLN 2235

  Fly  2253 MLSNPLSTKNK 2263
            .|.:|:..:.|
Human  2236 ALQSPIEYQRK 2246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706	75/138 (54%)
		SPEC	314..>468	CDD:238103	82/153 (54%)
		SPEC	563..778	CDD:238103	96/231 (42%)
		SPEC	782..997	CDD:238103	92/229 (40%)
		SPEC	897..1119	CDD:238103	125/240 (52%)
		SPEC	1125..1226	CDD:197544	60/100 (60%)
		RhoGEF	1287..1456	CDD:279015	107/169 (63%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	69/122 (57%)
		PH	1495..1580	CDD:278594	47/85 (55%)
		SH3_Kalirin_1	1643..1707	CDD:212786	26/63 (41%)
		RhoGEF	1945..2122	CDD:279015	75/176 (43%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061	42/137 (31%)
KALRN	XP_006713873.1	SEC14	41..179	CDD:214706	75/139 (54%)
		SPEC	192..412	CDD:238103	103/246 (42%)
		SPEC	313..538	CDD:238103	115/246 (47%)
		SPEC	539..768	CDD:238103	96/232 (41%)
		SPEC	893..1131	CDD:238103	125/240 (52%)
		SPEC	<1101..1240	CDD:295325	83/139 (60%)
		RhoGEF	1286..1456	CDD:238091	107/169 (63%)
		PH1_Kalirin_Trio_like	1463..1585	CDD:270060	69/122 (57%)
		PH	1496..1581	CDD:278594	47/85 (55%)
		SH3_Kalirin_1	1651..1710	CDD:212786	26/63 (41%)
		SH3-RhoG_link	1708..1934	CDD:293215	58/263 (22%)
		RhoGEF	1935..2105	CDD:279015	75/176 (43%)
		PH2_Kalirin_Trio_p63RhoGEF	2109..2243	CDD:270061	43/141 (30%)
		PH	2142..2228	CDD:278594	24/92 (26%)
		SH3_Kalirin_2	2327..2385	CDD:212787
		I-set	2473..2567	CDD:254352
		Ig	2490..2564	CDD:143165
		FN3	2571..2662	CDD:238020
		S_TKc	2686..2940	CDD:214567
		STKc_Kalirin_C	2692..2939	CDD:271017
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	236	1.000	Domainoid score	I2348
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1775	1.000	Inparanoid score	I69
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46230
OrthoDB	1	1.010	-	-		D4513at33208
OrthoFinder	1	1.000	-	-		FOG0002562
OrthoInspector	1	1.000	-	-		otm42181
orthoMCL	1	0.900	-	-		OOG6_103664
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3053
SonicParanoid	1	1.000	-	-		X1686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.770