DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and TUS1

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_013529.3 Gene:TUS1 / 851145 SGDID:S000004417 Length:1307 Species:Saccharomyces cerevisiae


Alignment Length:1562 Identity:286/1562 - (18%)
Similarity:481/1562 - (30%) Gaps:621/1562 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   449 SDIQSLETAIR---THQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGV--------- 501
            ||.|..::.:.   |..|.:.|.....:...||.|...|     |:....||||.:         
Yeast    61 SDTQQFQSPVPQAFTFTSKHSARGNGTSSSESTPKSTKY-----VKERRPPPPPPLLYSTESIRI 120

  Fly   502 ---------PDHRKNSNNGSF--NKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKW----- 550
                     ....::.|..||  |..||.:               :..|.:|.|.|::.:     
Yeast   121 DSPMVSPSSQSRERSPNKLSFIGNSEERHH---------------MEYISNHSRILKSPFANGFS 170

  Fly   551 ------------------HQERLRLHQ------------TLALRLFQEDVKQVLDWLKNHGEVFL 585
                              .:..||.|:            ||.|..|.::..:.  :.|....:..
Yeast   171 PNSPKSPRDSSKQQAHFSDESDLRCHEREKALPPIPFTTTLLLSPFDDEDSEF--FTKPPPPLST 233

  Fly   586 RKNTGIGRNFHKA--RVYQTSHDNFENVAQNTYSNAQK-----LLAAAD-ELARSGEADPNEIYS 642
            .:|........:|  .||..|...|.|      |||::     ||.|.. |||.|..| |.:.:|
Yeast   234 SRNVSGNSRVSEALESVYSDSDYTFNN------SNARQSSFNSLLGAKPLELAPSITA-PTQPFS 291

  Fly   643 VARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIERI 707
            :....|       .::.|......::.|:        .||.|:..: ..:|...::.:|..|.::
Yeast   292 IQSIDE-------HKLYQCDNVYKLSAIY--------EWILKVYFE-WFNECVFTKIDLFQIVQL 340

  Fly   708 LQQYQ------RDQQESSV-NVCLTTISQGEALLQEMRSLEYA---------------------- 743
            |.::|      :|..:|:| |:..:.|||.......:...|.|                      
Yeast   341 LLEFQMPTNFDQDTIDSNVDNIMASFISQKAVRFDIINDEEVAVVVGGLDITGVFTELLPCYSFI 405

  Fly   744 DNT-GSIAAL-----------------EATLEKLNKQKVEL-EELW---------------SARK 774
            ||| ||..:|                 |..|.::..:.|.| .|.|               ..:.
Yeast   406 DNTYGSTNSLICYSNVCTHGQSSGFRKEIKLSEIINKSVGLWTEYWHLTPDDLAEINPREVQRQS 470

  Fly   775 FRADLILRLRYFERDARLLSVQMEMWSEELQHADLSRDYQ-KA------EQLIRMHNESVTEIQN 832
            |..|||:   ..||...:.:..:|::.:....:.|..:.: ||      |.||::|.|.:  :..
Yeast   471 FIFDLII---LEERSLNMATAAVEIYGKRFDKSLLPDEPEFKALAFDIFEPLIQLHTEFL--LTP 530

  Fly   833 ATYEVVQQGQDLLQLFENAG-------------FISMADATHTAQARIEY-------LLDFLRER 877
            ..:::..:|    :..:..|             :::.|.|..|....|.:       .:.:|:| 
Yeast   531 IFWKLKTRG----KFIDGVGKIYSKWCGEAKNIYLNYAKAMATVHEIIMWEKKNKTKFVTWLKE- 590

  Fly   878 EIDLEEMSEAKRAKLEQAVQLC-----QFQNDANQVISWIRNGEAMLVASFVTPNSLQEAEQLR- 936
               ::...|..|:|:...|...     ..||....:.|.::|          |..|:::.|.|: 
Yeast   591 ---IDNSVEITRSKMYHDVIFFGGFFKSLQNMPVTLRSILKN----------TDPSMEDYEYLKI 642

  Fly   937 --KGHEQFQIAIEKTHTSAVQ----VKYRADALINANHYDPLSIDEI--------SDDVTKKWQQ 987
              |..|:....:.:.|..|:.    |::....:::.|..:..|...:        .|.:..|...
Yeast   643 VIKEVEKLNFEVNQVHGLAIDHRKLVRFSKQLVLSTNSSNATSYVNVGGSTNANDDDAIQDKLAL 707

  Fly   988 LVTYAEERHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCDGG----GGSDKAQAIVQLISK 1048
            .:||.|  .|||.:.                  ..||:.|.|.|..    ...|....|.:.|||
Yeast   708 GLTYPE--RKLVLSG------------------TVYKKRDLWLDPTPVYIALLDNCLLITEEISK 752

  Fly  1049 HQEQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQENQVLDYWTLRK 1113
            .:.||                             ||              |.:....:||.:|.|
Yeast   753 GETQK-----------------------------YK--------------LIERPIPIDYLSLEK 774

  Fly  1114 KSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGL-LKEHNEFRSTAKETRE 1177
            :.:.                                  |.||:..... .|||            
Yeast   775 RKIP----------------------------------GTSKQPLRNYSQKEH------------ 793

  Fly  1178 RVKLLIQLADSLVEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDG 1242
                          |...|                :||..::|             .:.||.|.|
Yeast   794 --------------KSPMH----------------NFSTPINS-------------MRPLLKSSG 815

  Fly  1243 NSSISSSSGDRHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIK 1307
            | .:|::.|||.:..|   :::::|....|.:.:.|.:|..:.|    ...||.|.|  |...|.
Yeast   816 N-HMSTAYGDRKTSNT---EISNANPNTDEFSFKIRNTATGESF----KFFTESAEV--LNQWID 870

  Fly  1308 CFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDM 1372
            ..:|.|:..                  .|.|         :|..:|         |...:|:|  
Yeast   871 AIMESFKRN------------------AENH---------DLNAFE---------FTVLSSEF-- 897

  Fly  1373 YVHYCKNKPTSNNLLVQHGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEE-- 1435
             .::.|:.|.  ||.|...||         |:|..|.||..|..:....:....:.|  |||:  
Yeast   898 -AYFDKDAPV--NLPVAPEGS---------EIDVALKAYAQKANKDSCSWSKTTRIL--CCEDVK 948

  Fly  1436 SHGEI------KEGLEVM--------------LNVPKKANDAMHLSLL----------------- 1463
            ..|.|      .:|:.|.              ||..|:....:.|.||                 
Yeast   949 FEGRIYLFVATTDGIYVKYRDDYGSGFVKILELNDVKRMEANVKLGLLFVLDNRKLCYFNISTVV 1013

  Fly  1464 -----------ENCDVSV---DKLGEVVLQDAFQAWDTKQII--RKGRERRVFLFELYLLFAKEV 1512
                       |||.|..   ||:....:.|.|  .::|.:.  |||:        :.:|..:..
Yeast  1014 SRYLAQGNTLDENCIVGTVIRDKVRFFKIADDF--GNSKHLFFERKGK--------IVILTPEFD 1068

  Fly  1513 KESNVVKYQFK----SKLMTTDMGITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWV 1573
            :.:|.||| ||    .||.::...|..:                .:.|..|..|:.::.||:   
Yeast  1069 QLTNQVKY-FKFYKEYKLPSSSNNILNN----------------EIEDIAIFRKSFAVCTKK--- 1113

  Fly  1574 KKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNK 1638
               ..::.:..|....:.||         |..:.:|:...|.   |...:...|.|  .|||..:
Yeast  1114 ---TVILYQDSFEDNGIVLP---------SFLNDKDMMAHLR---HPHLNSLPFKS--ATDSKKR 1161

  Fly  1639 LGNQEATWVVADYIATSGS---NELSVSKGQ------QVEIVEPPTAGEP----------DFC-- 1682
            ...:..|......|||..:   |...:|:..      ...:|:....||.          |||  
Yeast  1162 PSIESLTEEAKKDIATCKAIPVNFFQISQSSFFALVYDEAVVKINCYGEMSDWRKDILLLDFCCT 1226

  Fly  1683 ---------------LVRLNPQHDDAAVQEG---LVPVSVLKPPPGSHKHGSGTAANAASSAGSQ 1729
                           |:::   :|...|::.   ||||.::|          |.....|||...:
Yeast  1227 GASFHGNHLILVGDNLIQI---YDLKNVEQNLGELVPVQIIK----------GKKIKLASSERRE 1278

  Fly  1730 KS 1731
            |:
Yeast  1279 KT 1280

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103 5/21 (24%)
SPEC 563..778 CDD:238103 56/285 (20%)
SPEC 782..997 CDD:238103 43/261 (16%)
SPEC 897..1119 CDD:238103 42/245 (17%)
SPEC 1125..1226 CDD:197544 11/101 (11%)
RhoGEF 1287..1456 CDD:279015 39/190 (21%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 29/158 (18%)
PH 1495..1580 CDD:278594 15/88 (17%)
SH3_Kalirin_1 1643..1707 CDD:212786 19/102 (19%)
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
TUS1NP_013529.3 RhoGEF 469..655 CDD:238091 37/208 (18%)
CNH 939..1287 CDD:214481 78/404 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3601
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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