DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and VAV1

DIOPT Version :10

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_005419.2 Gene:VAV1 / 7409 HGNCID:12657 Length:845 Species:Homo sapiens


Alignment Length:410 Identity:89/410 - (21%)
Similarity:167/410 - (40%) Gaps:74/410 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly  1867 KESSGNMASPGKMDGNPLSEIEEIVKTTTEQHESNSRVDGGGGVENASTNGHGRSHDNNDESHTA 1931
            :||.|        |.:..|.:.:.:..|.|:.|     |....|||....|.....|.......:
Human   133 EESVG--------DEDIYSGLSDQIDDTVEEDE-----DLYDCVENEEAEGDEIYEDLMRSEPVS 184

  Fly  1932 VSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNI 1996
            :..|.....||.|...|:..|||.|...|..|...::.         |:...||...::::|.||
Human   185 MPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLK---------PLQRFLKPQDIEIIFINI 240

  Fly  1997 KDIYEWHRDFFLRALRNCQKSP--ADLGPLIKRSATKFALYYTYCS-----NKPLSEYIVSAHYQ 2054
            :|:...| ..||:.::....:|  |:|..:..:...:|.:|..|||     :|.| :.:.:|.  
Human   241 EDLLRVH-THFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHL-DRVAAAR-- 301

  Fly  2055 YFDSIRQKL--------GHRLDLSNLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQ 2111
              :.::.||        ..|..|.:|::.|:||:.||.||::|::|.|:.|   .|...|:.|..
Human   302 --EDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEA---MEKENLRLALD 361

  Fly  2112 QMKVVVKTVNDMM---VVLR-------SLQDFDGEITAQGSLLMQGPMNCVVDAAQKHRELQVFL 2166
            .|:.:.:.||::.   ..||       |:::.|..:...|...:.|.:.......:...:...||
Human   362 AMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFL 426

  Fly  2167 FQQIIIFADIEKTKNQYASPIFKYRSHIQLNHMQMKE--LGDCRFQIRSTDPKIPEMTIICQ--- 2226
            ..:.::..     |.:..|  :..:..:.|:..|:::  .||      ..:.|...|.::.:   
Human   427 LDKALLIC-----KRRGDS--YDLKDFVNLHSFQVRDDSSGD------RDNKKWSHMFLLIEDQG 478

  Fly  2227 AASQENYAGWRDMLNKILQQ 2246
            |...|.:...|::..|.::|
Human   479 AQGYELFFKTRELKKKWMEQ 498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1455 CDD:459876
PH1_Kalirin_Trio_like 1462..1584 CDD:270060
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2121 CDD:459876 48/190 (25%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 18/122 (15%)
VAV1NP_005419.2 CH_VAV1 2..121 CDD:409111
RhoGEF 195..371 CDD:238091 50/193 (26%)
PH_Vav 385..508 CDD:269930 19/127 (15%)
C1_VAV1 510..566 CDD:410417
SH3_VAV1_1 596..658 CDD:212912
SH2_Vav1 665..767 CDD:198268
SH3_VAV1_2 786..839 CDD:212909
Blue background indicates that the domain is not in the aligned region.

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