Protein Alignment trio and Arhgef6

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_690014.3
• Gene: Arhgef6 / 73341
• MGIID: 1920591
• Length: 771
• Species: Mus musculus
• Alignment Length: 568
• Identity: 117/568 - (20%)
• Similarity: 208/568 - (36%)
• Gaps: 160/568 - (28%)

  Fly  1287 IMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEK 1351
            ::..::.||:.|..:|.:.:..:|...::..::.:.   :...:.||.:|:..|.|.: .:.||:
Mouse   244 VLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTV---EFTCLLGNFEEVCTFQQTL-CQALEE 304

  Fly  1352 YETMPED---VGHCFVTWASKF-DMYVHYCKNKPTSNNLLVQHGGSFFEELQRRLE---VDHP-- 1407
            ....||:   ||.|.:.....| .||:.||.|.|::.|:|.||.    ::|:|.:|   ...|
Mouse   305 CSKFPENQHKVGGCLLNLMPHFKSMYLAYCANHPSAVNVLTQHS----DDLERFMENQGASSPGI 365

  Fly  1408 --LPAYLIKPVQRITKYQLLLKDLLSCCEESHGEIKEGLEVMLNVPKKANDAMHLSLLENC-DVS 1469
              |...|.||..|:.||..||::|....|::|.:.::.|:.::         ...:|:..| |:.
Mouse   366 LILTTSLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAII---------AFKTLMGQCQDLR 421

  Fly  1470 VDKLGEV-VLQDAFQAWDTKQIIRKG-----------------RERRVF-LFELYLLFAKEVKES 1515
            ..|..|: :|.:..|||:...|...|                 :|.|.| ||...|:........
Mouse   422 KRKQLELQILSEPIQAWEGDDIKTLGNVIFMSQVVMQHGACEEKEERYFLLFSSVLIMLSASPRM 486

  Fly  1516 NVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVM 1580
            :...||.|..:....:...:.|||.:..|.: ||.:..    |||:...:.:..|.|:::|..
Mouse   487 SGFMYQGKIPIAGMVVNRLDEIEGSDCMFEI-TGSTVE----RIVVHCNNNQDFQEWMEQLNR-- 544

  Fly  1581 QETCFSGTSLTLPKSPAKHSGSSQRSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNKLGNQEAT 1645
                       |.|.|......|:.||            ..||..|..|
Mouse   545 -----------LTKGPTSCGSLSKTSS------------SSCSTHSSFS---------------- 570

  Fly  1646 WVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPG 1710
                             |.||....:|||...:|                    ..:|.|:|.|.
Mouse   571 -----------------STGQPRGPLEPPQIIKP--------------------WSLSCLRPAPP 598

  Fly  1711 SHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWLPLMNRKGTDKPPSSK 1775
            ..          .|:|...|..|        :..|..|:|    |.:.....::::.|::..|.:
Mouse   599 LR----------PSAALGYKERM--------SYILKESSK----SPKTMKKFLHKRKTERKASEE 641

  Fly  1776 PLVKKPS----EKN---LRTPQKHAEELAEQQNQQPGASPATVLPSSQ 1816
            ..|.:.|    |::   |:..:.:....:.||..:..:.|..:||..:
Mouse   642 EYVIRKSTAALEEDAQILKVIEAYCTSASFQQGTRKDSVPQVLLPEEE 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1455	CDD:459876	45/178 (25%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	32/141 (23%)
		SH3_Kalirin_1	1643..1707	CDD:212786	9/63 (14%)
		RhoGEF	1945..2121	CDD:459876
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
Arhgef6	NP_690014.3	CH_alphaPIX	1..117	CDD:409114
		RhoGEF67_u1	115..159	CDD:465201
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..157
		SH3_alphaPIX	161..217	CDD:212993
		RhoGEF	241..418	CDD:238091	46/190 (24%)
		PH_Cool_Pix	449..547	CDD:269932	22/115 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	556..580		10/68 (15%)
		RhoGEF67_u2	575..673	CDD:465200	22/139 (16%)
		betaPIX_CC	680..764	CDD:465158	3/10 (30%)