DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and TRIO

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_009049.2 Gene:TRIO / 7204 HGNCID:12303 Length:3097 Species:Homo sapiens


Alignment Length:2340 Identity:1029/2340 - (43%)
Similarity:1459/2340 - (62%) Gaps:196/2340 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DGQRARDLLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNL 66
            |..:|.|:|.:|:|:|.:|:||||:||||:|.|||....||::.||||||:|||..|||:.....
Human    58 DEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVCKR 122

  Fly    67 GFTVIIDMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKYKFETTTVS 131
            |||||:||||:.  ..::|.:||:|||.|...||..:||||||||||||.:..|.|::|||..||
Human   123 GFTVIVDMRGSK--WDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNMVS 185

  Fly   132 IESLNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDV 196
            :|.|.|:|:..|||.:|:|...|:|::|.:.|:|.||:...|..|..|:::||:.|.:.:..:|:
Human   186 LEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDL 250

  Fly   197 PLARHAIDHHNEMRKKITKLPIEDLDMQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSAGQQ 261
            ..||:.|:.|::::||:.|.||||||::|:|||.:|                           |.
Human   251 EGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRI---------------------------QS 288

  Fly   262 SQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEKMF 326
            |:...:..|..||.|:...:.|....::.:|:.::.|..:|..:|:|||||||.||||||.||||
Human   289 SESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMF 353

  Fly   327 DWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVAARLIESQHYAAQH 391
            |||.||:.:|..||.|||.::..|..||.:|..||:..|||.|||:||::||.||:||.|||:|.
Human   354 DWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQ 418

  Fly   392 IKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQPLPSDIQSLET 456
            |:.:|.:|::.||.|||.||||:.:|.:|.:||.|||:|.::|.||..|| ....|||::|.||.
Human   419 IRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKAC-GEVDLPSELQDLED 482

  Fly   457 AIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHRKNSNNGSFNKYERQNP 521
            ||..||.:||.:..||:||....|.||.:|       .:|..||..|....|             
Human   483 AIHHHQGIYEHITLAYSEVSQDGKSLLDKL-------QRPLTPGSSDSLTAS------------- 527

  Fly   522 AADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQEDVKQVLDWLKNHGEVFLR 586
             |:||:...|||.|||::|.|.|.||..|...::||||.|.|.:||:||:|||||::||||.||.
Human   528 -ANYSKAVHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLS 591

  Fly   587 KNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGEADPNEIYSVARELELQV 651
            |:||:|::.|:||..|..|::||.||||||:||.|||.||::||::||.||.|||..|.:||.::
Human   592 KHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRI 656

  Fly   652 GSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQ 716
            ..|..|||||:..|||:|.|:||.|::..|:::|:.::..|   :..|::|.::.:::::.: ||
Human   657 QDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDD---VYAESVEAVQDLIKRFGQ-QQ 717

  Fly   717 ESSVNVCLTTISQGEALLQEMRSLEYADN----TGSIAALEATLEKLNKQKVELEELWSARKFRA 777
            ::::.|.:..|.:||.|:|::|....:.|    ..||..:|..|::|::.:.::|||:..||.:.
Human   718 QTTLQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKL 782

  Fly   778 DLILRLRYFERDARLLSVQMEMWSEEL--QHADL-SRDYQKAEQLIRMHNESVTEIQNATYEVVQ 839
            :|.|:||.|||||..:...:|.|::||  |..|. :.|...|||.::.|.:....:.|.|::|:.
Human   783 ELFLQLRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIH 847

  Fly   840 QGQDLLQL---FENAGFISMADATHTAQARIEYLLDFLREREIDLEEMSEAKRAKLEQAVQLCQF 901
            |||||||.   .:.:|...:.|.......|::.||:||.|::.:|:..:|..|..|||.|||...
Human   848 QGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHL 912

  Fly   902 QNDANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIEKTHTSAVQVKYRADALINA 966
            |.:..||:.||||||:||.|..:|.:||||||||::.|||||.||||||.||:||:.:|:|::.|
Human   913 QAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQA 977

  Fly   967 NHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCD 1031
            ||||...|.:.::.|...||||:...|:|.|||.||:.||||:|||||||:|||:|||||:||| 
Human   978 NHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWC- 1041

  Fly  1032 GGGGSDK------AQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEG- 1089
              ||:||      ...:..:||||.|||||||||||||||.|:.||||.:|:..      |..| 
Human  1042 --GGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRNSV------NMPGM 1098

  Fly  1090 ---------HVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLS 1145
                     .||:.|::|..:||:||.|||:||:.||||||:|:||||||||:||||:.||.|||
Human  1099 VTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLS 1163

  Fly  1146 SRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQR 1210
            :.:: .|.|.:.|:.|||||.||:.|||:|:|||||||||||...|||||||::||:.|.:||:|
Human  1164 THTS-TGSSIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKR 1227

  Fly  1211 YKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGD--RHSDPTLEAKLNSSNKENKEI 1273
            |:|||.||:.|...|||:||:|       ||.|.|..|...|  ..|.|..|.||..:   ..|:
Human  1228 YRDFSLRMEKYRTSLEKALGIS-------SDSNKSSKSLQLDIIPASIPGSEVKLRDA---AHEL 1282

  Fly  1274 NEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAG-KSVPSALIGQEDVIFGNIKEI 1337
            ||||||||||||||||||:|||:|||.||..|:..:|.|..:| :.:|..::.:|.:||||::||
Human  1283 NEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEI 1347

  Fly  1338 HHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGGSFFEELQRRL 1402
            :.||..|||:||||||.:||||||||||||.||.|||.||||||.|..|:::|.||:|:|:|:|.
Human  1348 YEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRH 1412

  Fly  1403 EVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEESHGEIKEGLEVMLNVPKKANDAMHLSLLENCD 1467
            .:.:.:.:|||||||||||||||||:||:||||..||||:||||||:|||:||||||||:||..|
Human  1413 GLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFD 1477

  Fly  1468 VSVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVKESN-VVKYQFKSKLMTTDM 1531
            .:::..||::||::||.||.|.:|||||||.:||||:.|:|:||||:|: ..||.:||||.|:::
Human  1478 ENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSEL 1542

  Fly  1532 GITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETC--FSGT---SLT 1591
            |:|||:|||..|||:|.||:| .||.:|||||:|:|.||.|:|.:|||:||..  ..|.   .:.
Human  1543 GVTEHVEGDPCKFALWVGRTP-TSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIH 1606

  Fly  1592 LPKSPAKHSGSSQRSSRDLDEQLT-ENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYIATS 1655
            :||:........:|...|||.|.. .:..|..|:||..|.||.|||...|..|.|.|:.|:.|.:
Human  1607 IPKTAPATRQKGRRDGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACN 1671

  Fly  1656 GSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVL--------KPPPG-- 1710
             ||||::.:||.||::|.| ..:||:||||..   |.:...|||||...|        ....|  
Human  1672 -SNELTIRRGQTVEVLERP-HDKPDWCLVRTT---DRSPAAEGLVPCGSLCIAHSRSSMEMEGIF 1731

  Fly  1711 SHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWL--PLMN--------- 1764
            :||.....::|.||...|..| :|.....:::   |...||.|.:.|.||  |:..         
Human  1732 NHKDSLSVSSNDASPPASVAS-LQPHMIGAQS---SPGPKRPGNTLRKWLTSPVRRLSSGKADGH 1792

  Fly  1765 -RKGTDKPPSSKPLVK-------KPSEKNLRTPQKHAEELAEQQNQQPGASPATVLPSSQFPSST 1821
             :|...|...|:.:.|       |.|:.:..|||   :|..|::.:..|.|..|:..||.     
Human  1793 VKKLAHKHKKSREVRKSADAGSQKDSDDSAATPQ---DETVEERGRNEGLSSGTLSKSSS----- 1849

  Fly  1822 QHPGGAGAGDYEPDEEV-GLELPPPMKPIQEPHLIANGPPAFAKDAKESSGNMASPGKMD----G 1881
              .|....|:.|.:|.. .:.||||| .||:..|:...    ::|.|.||..:..|...:    .
Human  1850 --SGMQSCGEEEGEEGADAVPLPPPM-AIQQHSLLQPD----SQDDKASSRLLVRPTSSETPSAA 1907

  Fly  1882 NPLSEIEEIVKT--TTEQHESNSRVDGGGGVE---NASTNGHGRSHDNNDESHTAVSDKAAALKK 1941
            ..:|.|||:||:  ..|...|:..||.|....   |.|.|....|....||..   ..|:::||:
Human  1908 ELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEME---ERKSSSLKR 1969

  Fly  1942 RQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDF 2006
            |..|..||:.||..||:||..:|.|||..:....    :|:|:| ||.|:||.||..||:|||||
Human  1970 RHYVLQELVETERDYVRDLGYVVEGYMALMKEDG----VPDDMK-GKDKIVFGNIHQIYDWHRDF 2029

  Fly  2007 FLRALRNCQKSPADLGPLIKRSATKFALYYTYCSNKPLSEYIVSAHYQ-YFDSIRQKLGHRLDLS 2070
            ||..|..|.:.|..||.|..:...:..:|..||.|||.||:|||.:.. :|:.::|:|||||.|:
Human  2030 FLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLT 2094

  Fly  2071 NLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVNDMMVVLRSLQDFDG 2135
            :|:|||||||.||:||:|:.:|.::.|.|  :...|:.|.:.|.:|.:..||||.|.| ||.|||
Human  2095 DLLIKPVQRIMKYQLLLKDFLKYSKKASL--DTSELERAVEVMCIVPRRCNDMMNVGR-LQGFDG 2156

  Fly  2136 EITAQGSLLMQGPMNCVVD----AAQKHRELQVFLFQQIIIFADIEKTKNQYASPIFKYRSHIQL 2196
            :|.|||.||:|... .|.|    ...:.||.::|||:||:||::....|..::.|.|.:::.|::
Human  2157 KIVAQGKLLLQDTF-LVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKV 2220

  Fly  2197 NHMQMKELGD---CRFQIRSTDPKIPEMTIICQAASQENYAGWRDMLNKILQQQNDLIFMLSNPL 2258
            :.:.::|..:   |:|.:.|....:.| |.|..::|......|...:|:||:.|.:.:..|::|:
Human  2221 SCLCLEENVENDPCKFALTSRTGDVVE-TFILHSSSPSVRQTWIHEINQILENQRNFLNALTSPI 2284

  Fly  2259  2258
            Human  2285  2284

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706 76/138 (55%)
SPEC 314..>468 CDD:238103 83/153 (54%)
SPEC 563..778 CDD:238103 91/218 (42%)
SPEC 782..997 CDD:238103 96/220 (44%)
SPEC 897..1119 CDD:238103 126/237 (53%)
SPEC 1125..1226 CDD:197544 62/100 (62%)
RhoGEF 1287..1456 CDD:279015 105/169 (62%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 69/122 (57%)
PH 1495..1580 CDD:278594 50/85 (59%)
SH3_Kalirin_1 1643..1707 CDD:212786 28/71 (39%)
RhoGEF 1945..2122 CDD:279015 77/177 (44%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 42/136 (31%)
TRIONP_009049.2 SEC14 69..204 CDD:214706 75/136 (55%)
SPEC 230..445 CDD:238103 99/241 (41%)
Spectrin 1 311..418 55/106 (52%)
SPEC 341..566 CDD:238103 115/246 (47%)
Spectrin 2 538..644 61/105 (58%)
SPEC 567..783 CDD:238103 91/219 (42%)
SPEC 787..1014 CDD:238103 100/226 (44%)
Spectrin 3 878..984 57/105 (54%)
SPEC 908..1137 CDD:238103 126/237 (53%)
Spectrin 4 1109..1216 69/107 (64%)
SPEC 1143..1243 CDD:197544 62/100 (62%)
RhoGEF 1295..1465 CDD:238091 105/169 (62%)
PH1_Kalirin_Trio_like 1472..1594 CDD:270060 69/122 (57%)
PH 1505..1590 CDD:278594 50/85 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1601..1650 14/48 (29%)
SH3_Kalirin_1 1659..1718 CDD:212786 28/63 (44%)
SH3-RhoG_link 1715..1972 CDD:293215 72/278 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1779..1906 34/141 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1927..1965 11/40 (28%)
RhoGEF 1970..2143 CDD:238091 78/179 (44%)
PH2_Kalirin_Trio_p63RhoGEF 2148..2286 CDD:270061 44/140 (31%)
PH 2175..2271 CDD:278594 24/96 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2287..2552
SH3_Kalirin_2 2555..2613 CDD:212787
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2639..2660
I-set 2685..2776 CDD:254352
Ig 2699..2776 CDD:299845
STKc_Trio_C 2788..3050 CDD:271015
S_TKc 2796..3050 CDD:214567
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 236 1.000 Domainoid score I2348
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20847
Inparanoid 1 1.050 1775 1.000 Inparanoid score I69
Isobase 1 0.950 - 0 Normalized mean entropy S5434
OMA 1 1.010 - - QHG46230
OrthoDB 1 1.010 - - D4513at33208
OrthoFinder 1 1.000 - - FOG0002562
OrthoInspector 1 1.000 - - otm42181
orthoMCL 1 0.900 - - OOG6_103664
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1686
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.690

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