Sequence 1: | NP_651960.2 | Gene: | trio / 43974 | FlyBaseID: | FBgn0024277 | Length: | 2263 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_009049.2 | Gene: | TRIO / 7204 | HGNCID: | 12303 | Length: | 3097 | Species: | Homo sapiens |
Alignment Length: | 2340 | Identity: | 1029/2340 - (43%) |
---|---|---|---|
Similarity: | 1459/2340 - (62%) | Gaps: | 196/2340 - (8%) |
- Green bases have known domain annotations that are detailed below.
Fly 2 DGQRARDLLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNL 66
Fly 67 GFTVIIDMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKYKFETTTVS 131
Fly 132 IESLNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDV 196
Fly 197 PLARHAIDHHNEMRKKITKLPIEDLDMQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSAGQQ 261
Fly 262 SQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEKMF 326
Fly 327 DWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVAARLIESQHYAAQH 391
Fly 392 IKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQPLPSDIQSLET 456
Fly 457 AIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHRKNSNNGSFNKYERQNP 521
Fly 522 AADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQEDVKQVLDWLKNHGEVFLR 586
Fly 587 KNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGEADPNEIYSVARELELQV 651
Fly 652 GSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQ 716
Fly 717 ESSVNVCLTTISQGEALLQEMRSLEYADN----TGSIAALEATLEKLNKQKVELEELWSARKFRA 777
Fly 778 DLILRLRYFERDARLLSVQMEMWSEEL--QHADL-SRDYQKAEQLIRMHNESVTEIQNATYEVVQ 839
Fly 840 QGQDLLQL---FENAGFISMADATHTAQARIEYLLDFLREREIDLEEMSEAKRAKLEQAVQLCQF 901
Fly 902 QNDANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIEKTHTSAVQVKYRADALINA 966
Fly 967 NHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCD 1031
Fly 1032 GGGGSDK------AQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEG- 1089
Fly 1090 ---------HVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLS 1145
Fly 1146 SRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQR 1210
Fly 1211 YKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGD--RHSDPTLEAKLNSSNKENKEI 1273
Fly 1274 NEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAG-KSVPSALIGQEDVIFGNIKEI 1337
Fly 1338 HHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGGSFFEELQRRL 1402
Fly 1403 EVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEESHGEIKEGLEVMLNVPKKANDAMHLSLLENCD 1467
Fly 1468 VSVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVKESN-VVKYQFKSKLMTTDM 1531
Fly 1532 GITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETC--FSGT---SLT 1591
Fly 1592 LPKSPAKHSGSSQRSSRDLDEQLT-ENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYIATS 1655
Fly 1656 GSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVL--------KPPPG-- 1710
Fly 1711 SHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWL--PLMN--------- 1764
Fly 1765 -RKGTDKPPSSKPLVK-------KPSEKNLRTPQKHAEELAEQQNQQPGASPATVLPSSQFPSST 1821
Fly 1822 QHPGGAGAGDYEPDEEV-GLELPPPMKPIQEPHLIANGPPAFAKDAKESSGNMASPGKMD----G 1881
Fly 1882 NPLSEIEEIVKT--TTEQHESNSRVDGGGGVE---NASTNGHGRSHDNNDESHTAVSDKAAALKK 1941
Fly 1942 RQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDF 2006
Fly 2007 FLRALRNCQKSPADLGPLIKRSATKFALYYTYCSNKPLSEYIVSAHYQ-YFDSIRQKLGHRLDLS 2070
Fly 2071 NLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVNDMMVVLRSLQDFDG 2135
Fly 2136 EITAQGSLLMQGPMNCVVD----AAQKHRELQVFLFQQIIIFADIEKTKNQYASPIFKYRSHIQL 2196
Fly 2197 NHMQMKELGD---CRFQIRSTDPKIPEMTIICQAASQENYAGWRDMLNKILQQQNDLIFMLSNPL 2258
Fly 2259 2258 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
trio | NP_651960.2 | SEC14 | 13..152 | CDD:214706 | 76/138 (55%) |
SPEC | 314..>468 | CDD:238103 | 83/153 (54%) | ||
SPEC | 563..778 | CDD:238103 | 91/218 (42%) | ||
SPEC | 782..997 | CDD:238103 | 96/220 (44%) | ||
SPEC | 897..1119 | CDD:238103 | 126/237 (53%) | ||
SPEC | 1125..1226 | CDD:197544 | 62/100 (62%) | ||
RhoGEF | 1287..1456 | CDD:279015 | 105/169 (62%) | ||
PH1_Kalirin_Trio_like | 1462..1584 | CDD:270060 | 69/122 (57%) | ||
PH | 1495..1580 | CDD:278594 | 50/85 (59%) | ||
SH3_Kalirin_1 | 1643..1707 | CDD:212786 | 28/71 (39%) | ||
RhoGEF | 1945..2122 | CDD:279015 | 77/177 (44%) | ||
PH2_Kalirin_Trio_p63RhoGEF | 2130..2260 | CDD:270061 | 42/136 (31%) | ||
TRIO | NP_009049.2 | SEC14 | 69..204 | CDD:214706 | 75/136 (55%) |
SPEC | 230..445 | CDD:238103 | 99/241 (41%) | ||
Spectrin 1 | 311..418 | 55/106 (52%) | |||
SPEC | 341..566 | CDD:238103 | 115/246 (47%) | ||
Spectrin 2 | 538..644 | 61/105 (58%) | |||
SPEC | 567..783 | CDD:238103 | 91/219 (42%) | ||
SPEC | 787..1014 | CDD:238103 | 100/226 (44%) | ||
Spectrin 3 | 878..984 | 57/105 (54%) | |||
SPEC | 908..1137 | CDD:238103 | 126/237 (53%) | ||
Spectrin 4 | 1109..1216 | 69/107 (64%) | |||
SPEC | 1143..1243 | CDD:197544 | 62/100 (62%) | ||
RhoGEF | 1295..1465 | CDD:238091 | 105/169 (62%) | ||
PH1_Kalirin_Trio_like | 1472..1594 | CDD:270060 | 69/122 (57%) | ||
PH | 1505..1590 | CDD:278594 | 50/85 (59%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1601..1650 | 14/48 (29%) | |||
SH3_Kalirin_1 | 1659..1718 | CDD:212786 | 28/63 (44%) | ||
SH3-RhoG_link | 1715..1972 | CDD:293215 | 72/278 (26%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1779..1906 | 34/141 (24%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1927..1965 | 11/40 (28%) | |||
RhoGEF | 1970..2143 | CDD:238091 | 78/179 (44%) | ||
PH2_Kalirin_Trio_p63RhoGEF | 2148..2286 | CDD:270061 | 44/140 (31%) | ||
PH | 2175..2271 | CDD:278594 | 24/96 (25%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2287..2552 | ||||
SH3_Kalirin_2 | 2555..2613 | CDD:212787 | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2639..2660 | ||||
I-set | 2685..2776 | CDD:254352 | |||
Ig | 2699..2776 | CDD:299845 | |||
STKc_Trio_C | 2788..3050 | CDD:271015 | |||
S_TKc | 2796..3050 | CDD:214567 | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 1 | 1.000 | 236 | 1.000 | Domainoid score | I2348 |
eggNOG | 1 | 0.900 | - | - | E1_KOG4240 | |
Hieranoid | 1 | 1.000 | - | - | ||
Homologene | 1 | 1.000 | - | - | H20847 | |
Inparanoid | 1 | 1.050 | 1775 | 1.000 | Inparanoid score | I69 |
Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S5434 |
OMA | 1 | 1.010 | - | - | QHG46230 | |
OrthoDB | 1 | 1.010 | - | - | D4513at33208 | |
OrthoFinder | 1 | 1.000 | - | - | FOG0002562 | |
OrthoInspector | 1 | 1.000 | - | - | otm42181 | |
orthoMCL | 1 | 0.900 | - | - | OOG6_103664 | |
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 1 | 1.000 | - | - | X1686 | |
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 1 | 0.960 | - | - | ||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
14 | 13.690 |