DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trio and Arhgef3

DIOPT Version :9

Sequence 1:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster
Sequence 2:	NP_001276615.1	Gene:	Arhgef3 / 71704	MGIID:	1918954	Length:	551	Species:	Mus musculus

Alignment Length:	439	Identity:	92/439 - (20%)
Similarity:	167/439 - (38%)	Gaps:	114/439 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1845 PMKPIQEPHLIANGPPAF---AKDAKESSG----------NMASPGKMDGNPLSEIEEI------ 1890
            |.:|.|....:...|.|:   .:..|:||.          :::.|......|||.:..:
Mouse    16 PKRPRQNNFSMFPSPKAWNFRGRKRKQSSQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPP 80

  Fly  1891 VKTT-------TEQH----ESNSRVD--GGGGVENASTNGHGRSHDNNDESHT---AVSD--KAA 1937
            ||||       |.|.    .|.||.|  ........:|:...:..|:...|.|   .|:.  .|.
Mouse    81 VKTTPLKRFSQTLQRSISFRSESRPDILAPRAWSRNATSSSTKRRDSKLWSETFDVCVNQVLTAK 145

  Fly  1938 ALKKRQCVFAELMSTEEAYVQDLHEIVNGY---------MTEINNTNSDIPMPEDLKGGKMKLVF 1993
            .:|:::.:| ||...||..::||......|         |||                .::..:|
Mouse   146 EIKRQEAIF-ELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTE----------------QELNQIF 193

  Fly  1994 NNIKDIYEWHRDFF--LRALRNCQKSPADLGPLIKRSATKFALYYTYCSNKPLSEYIV---SAHY 2053
            ..:..:...|.:..  ||.:|....|...:||::.......:.|.:||||:..::.::   ...:
Mouse   194 GTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDH 258

  Fly  2054 QYFDSIRQKL----GHRLDLSNLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMK 2114
            :..|.:::.|    ..:|||.|.:..|..|:.||.||::||::.|....  .:...|:||...::
Mouse   259 RVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDN--PDQQHLEEAINIIQ 321

  Fly  2115 VVVKTVNDMMVVLRSLQDFDGEITAQGS-----------LLMQGPMNCVVDAAQK---HRELQ-- 2163
            .:|..:|                |..|.           .|.:|..:.::|:::.   |.||:
Mouse   322 GIVAEIN----------------TKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNN 370

  Fly  2164 ------VFLFQQIIIFADIEKTKNQYASPIFKYRSHIQLNHMQMKELGD 2206
                  |||||::::.........|....:  ||..|.:..:.:::|.|
Mouse   371 RGVKLHVFLFQEVLVITRAVTHNEQLCYQL--YRQPIPVKDLTLEDLQD 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1456	CDD:279015
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		PH	1495..1580	CDD:278594
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2122	CDD:279015	43/194 (22%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061	19/99 (19%)
Arhgef3	NP_001276615.1	RhoGEF	152..328	CDD:366202	43/194 (22%)
Arhgef3	NP_001276615.1	PH_RhoGEF3_XPLN	342..474	CDD:269976	17/78 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030