Protein Alignment trio and TIAM1

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_003244.2
• Gene: TIAM1 / 7074
• HGNCID: 11805
• Length: 1591
• Species: Homo sapiens
• Alignment Length: 75
• Identity: 20/75 - (26%)
• Similarity: 38/75 - (50%)
• Gaps: 6/75 - (8%)

  Fly    10 REEVFQKLRSMRERYLPHVTDVYQRLADKLNHEESLPQQQRSKHFDKFQSMK---TNIEQLIQV- 70
            :||.|..|.|..|:...::||:..:..:|.:.|:.|.:.:.....|..:.||   .|..||.::
Human   768 KEEQFNVLSSELEKLRENLTDMEAKFKEKDDREDQLVKAKEKLENDIAEIMKMSGDNSSQLTKMN 832

  Fly    71 --LSLRKRNI 78
              |.|::|::
Human   833 DELRLKERSV 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706	18/72 (25%)
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1455	CDD:459876
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2121	CDD:459876
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
TIAM1	NP_003244.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..379
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..422
		PH1_Tiam1_2	432..558	CDD:269937
		Tiam_CC_Ex	572..669	CDD:408184
		Ubl1_cv_Nsp3_N-like	766..832	CDD:475130	17/63 (27%)
		PDZ	858..>901	CDD:214570
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	939..1034
		RhoGEF	1044..1233	CDD:214619
		PH2_Tiam1_2	1235..1406	CDD:269957
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1456..1482