Protein Alignment trio and PLEKHG2

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_073746.2
• Gene: PLEKHG2 / 64857
• HGNCID: 29515
• Length: 1386
• Species: Homo sapiens
• Alignment Length: 788
• Identity: 185/788 - (23%)
• Similarity: 308/788 - (39%)
• Gaps: 201/788 - (25%)

  Fly  1239 GSDGNSSISS--SSGDRHSDPTLEAKLNSSNKENKE------------INEEKRKSARRKEFIMA 1289
            ||..::|:|:  |.||....||  ...::|..|...            |....|.|  |.|.:..
Human    48 GSGSSTSLSTVGSEGDPAPGPT--PACSASRPEPLPGPPIRLHLSPVGIPGSARPS--RLERVAR 108

  Fly  1290 ELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIG----QEDVIFGNIKEIHHFHQKIFLRELE 1350
            |:::||||||.||.:.::.:|     |..:...::|    |...:|.||::|:.|..:: |.:||
Human   109 EIVETERAYVRDLRSIVEDYL-----GPLLDGGVLGLSVEQVGTLFANIEDIYEFSSEL-LEDLE 167

  Fly  1351 KYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGGS-----FFEELQRRLEVDHPLPA 1410
            . .:....:..|||..:..||:|..||.|.|:|..||.:...|     :.:|.|.:|....||.:
Human   168 N-SSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQS 231

  Fly  1411 YLIKPVQRITKYQLLLKDLLSCCEESHGE-----IKEGLEVMLNVPKKANDAM----HLSLLENC 1466
            :|:||||||.||.|||::|.....|..|.     ::|.:..|..|....||..    |.:.|:..
Human   232 FLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEV 296

  Fly  1467 D--------VSVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVKESNVVKYQFK 1523
            .        ..:...||:||:.||:.........:|.||.:|||...||.||.    ..::|.:|
Human   297 QRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKR----RGLEYTYK 357

  Fly  1524 SKLMTTDMGITEHIEGDETKFAVWTGRSPM---LSDCRI-----VLKATSLETKQIWVKKLREVM 1580
            ..:...::.::|            :.|.|:   :||..|     :|:|.:.|.|::|:    ..:
Human   358 GHIFCCNLSVSE------------SPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWI----HCL 406

  Fly  1581 QETCFSGTSLTLPKSPAK-----HSGSSQRSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNKLG 1640
            |...|.....::| :.||     :|......|:.:.|.||         ...||....|:.:...
Human   407 QRLFFENHPASIP-AKAKQVLLENSLHCAPKSKPVLEPLT---------PPLGSPRPRDARSFTP 461

  Fly  1641 NQEATWVVADYIATSGSNELSVSKGQQVEIVEP----PTAGEPDFCLVRLNPQHDDAAVQEGLVP 1701
            .:..|      ..:.|.:.:...:.|...:.:|    |...:|.|       :|   |..||.:
Human   462 GRRNT------APSPGPSVIRRGRRQSEPVKDPYVMFPQNAKPGF-------KH---AGSEGEL- 509

  Fly  1702 VSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWLPLMNRK 1766
                 .||.|....||:|         ...|::|....:...:.:|.|:       ..|.|:|::
Human   510 -----YPPESQPPVSGSA---------PPEDLEDAGPPTLDPSGTSITE-------EILELLNQR 553

  Fly  1767 GTDKP-PSSKPLVKKPSEKNL----------RTPQKHAEELAEQQNQ-----QPGASPATVL--- 1812
            |...| ||:..:.|.|.:..:          ..|.:.:.|..|::.:     :.|.||..||
Human   554 GLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLEMDERGPSPLHVLEGL 618

  Fly  1813 --------PS-------------SQFPSSTQHPGGAGAGDYEPDEEVGLELP--PPMKPIQEPHL 1854
                    ||             .:.||..:.|.|:.........:| .|:|  |.:..:.....
Human   619 ESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLSDISDV-FEMPCLPAIPSVPNTPS 682

  Fly  1855 IANGP--------------PAFAKDAKESSGNMASPGKMDGNPLS-------EIEEIVKTTTEQH 1898
            :::.|              ||.|...:....:.::|||: |.|.|       |.||.|..|..|.
Human   683 LSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGKL-GEPPSGGKAGPEEDEEGVSFTDFQP 746

  Fly  1899 ESNSRVDG 1906
            :..::..|
Human   747 QDVTQHQG 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1455	CDD:459876	58/181 (32%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	31/137 (23%)
		SH3_Kalirin_1	1643..1707	CDD:212786	11/67 (16%)
		RhoGEF	1945..2121	CDD:459876
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
PLEKHG2	NP_073746.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..82		11/35 (31%)
		RhoGEF	106..281	CDD:459876	58/181 (32%)
		PH_PLEKHG1_G2_G3	263..413	CDD:270063	38/169 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..540		26/143 (18%)
		PHA03247	<443..904	CDD:223021	70/361 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	554..612		11/57 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	701..739		12/38 (32%)
		Atrophin-1	769..>1153	CDD:460830
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	790..815
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	829..859
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1037..1099
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1162..1191
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1291..1333
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1367..1386