DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and Arhgef26

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_001074764.1 Gene:Arhgef26 / 622434 MGIID:1918053 Length:869 Species:Mus musculus


Alignment Length:830 Identity:161/830 - (19%)
Similarity:283/830 - (34%) Gaps:231/830 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  1520 YQFKSKLMTTDMGITE-----------HIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWV 1573
            ||..|.|:.||..:.|           .:..|.....|  .|||.|           |...:..|
Mouse    39 YQSPSGLLITDFPVEELAALPTPQTPVRVPADPDDRTV--SRSPQL-----------LSAHRRPV 90

  Fly  1574 KKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNK 1638
            ...|.|..:...:...|..||||.....:|..|.:........:.....|.||    .|.|:...
Mouse    91 TNGRTVSPDYRAASPRLRRPKSPLVSYAASGGSPKSTSNGTVASPAALLSRAS----RTPDTPAS 151

  Fly  1639 LG-NQEATWVVADYIATSGSNEL---SVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGL 1699
            .. :::.|.|.|..:::..:|.|   :.|.|...:..:|  ||:.:....||:|.....:.::.|
Mouse   152 CATDEDCTGVTASKVSSPIANGLAHKTDSSGPVSQTGQP--AGDLELAPSRLSPALPHKSSEQKL 214

  Fly  1700 VPVSVLKPPPGSHKHGS----GTAANAASSAGSQK---SDMQDQSNRSKADALSSSTKRRGFSGR 1757
             |:..| |..|:.....    .|.:.||...|.|:   ..:..:...||:::.:..:.||....|
Mouse   215 -PLQRL-PSQGNELPNPSVVLSTNSPAALKMGKQQIIPKSLASEIKLSKSNSQNVESHRRLLKVR 277

  Fly  1758 NWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQPGASPATVLPSSQFPSSTQ 1822
            :.:                       :.|..|..|..|..|..|....            |.|.:
Mouse   278 SMV-----------------------EGLGAPLGHEGEEGEVDNDMDS------------PGSLR 307

  Fly  1823 HPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIANGPPAFAKDAKESSGNMASPGKMDGNPLSEI 1887
            .  |..:..|......|.:...|                   .:.:....|:.|           
Mouse   308 R--GLRSTSYRRAVVSGFDFDSP-------------------TSSKKKNRMSQP----------- 340

  Fly  1888 EEIVKTTTEQHESNSR--------VDGGG---GVENA--STNGHGRSHD-NNDESHTAVSDKA-- 1936
              ::|...|..|..|.        :.|.|   |.|||  ..|...::.| ::||...|...||  
Mouse   341 --VLKAVMEDKEKFSSLGRIKKKILKGQGTFDGEENAVLYQNYKEKALDIDSDEEPEAKEQKAEE 403

  Fly  1937 ----------------AALK-------------KRQCVFAELMSTEEAYVQDLHEIVNGYMT--E 1970
                            :|:|             |||....|::|:|.:|:..|..::..:..  |
Mouse   404 RIVIHHKPLRSTWSQLSAVKRNGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKE 468

  Fly  1971 INNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFF--LRALRNCQKSPADLGPLI-KRSATKF 2032
            :.:|         :...:...:|:||.|::|..:.||  |.|.........|:..:: |.:|:.|
Mouse   469 LTDT---------MTKTERHHLFSNITDVWEASKKFFTELEARHQNNIFIEDISDIVEKHTASTF 524

  Fly  2033 ALYYTYCSNKPLSEYIVS---AHYQYFDSIRQKLGHRLDLSNL-----IIKPVQRITKYELLIKE 2089
            ..|..||:|:...:..:.   |....|..:..::....|..||     :|.|:||:|:..||:..
Mouse   525 DPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDT 589

  Fly  2090 IIKATEGAGLYKEVPMLQEAYQQMKVVVKTV------------NDMMVVLRSLQDFD-------- 2134
            |.:.|.     |:.|..:...:.:|.|.|.|            .:||..:.|..:|.        
Mouse   590 ICQKTP-----KDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVS 649

  Fly  2135 --------GEITA--QGSLLMQGPMNCVVDAAQKHRELQVFLFQQIIIFADIEKTKNQYASPIFK 2189
                    ||:||  :.::|....|:        .:::..|||..::|... :|::..|....:.
Mouse   650 SSRWLVKRGELTAYVEDTVLFSKRMS--------KQQVYFFLFNDVLIITK-KKSEESYNVNDYS 705

  Fly  2190 YRSHI--------QLNHMQMKELGDCRFQIRSTDPKIPEMTIICQAASQE 2231
            .|..:        :||....|......:..:|:...:..:|::...||::
Mouse   706 LRDQLLVESCDNEELNSSPGKNPSTMLYSRQSSATHLFTLTVLSNHASEK 755

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1456 CDD:279015
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 17/74 (23%)
PH 1495..1580 CDD:278594 16/70 (23%)
SH3_Kalirin_1 1643..1707 CDD:212786 16/66 (24%)
RhoGEF 1945..2122 CDD:279015 44/201 (22%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 21/128 (16%)
Arhgef26NP_001074764.1 RhoGEF 441..620 CDD:279015 44/192 (23%)
PH_ephexin 641..779 CDD:269929 20/124 (16%)
SH3_ARHGEF16_26 791..845 CDD:212871
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3601
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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