Protein Alignment trio and Vav3

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_001365916.1
• Gene: Vav3 / 57257
• MGIID: 1888518
• Length: 875
• Species: Mus musculus
• Alignment Length: 368
• Identity: 85/368 - (23%)
• Similarity: 149/368 - (40%)
• Gaps: 81/368 - (22%)

  Fly  1919 GRSHDNNDESHTAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPED 1983
            |..:::..::..|...|:.....|.|..||:..|||.|.:.|..|...:|.         |:...
Mouse   170 GEVYEDLMKAEEAQQPKSQENDIRSCCLAEIRQTEEKYTETLESIEKYFMA---------PLKRF 225

  Fly  1984 LKGGKMKLVFNNIKDIYEWHRDFFLRALRN--CQKSPADLGPLIKRSATKFALYYTYCSNKPLSE 2046
            |...:...||.||.|:.:.||. .::.:.:  ..|...:|..:......:..:|..|||.
Mouse   226 LTAAEFDSVFINIPDLVKVHRS-LMQEIHDSIVNKDDQNLYQVFINYKERLVIYGQYCSG----- 284

  Fly  2047 YIVSA--HYQYFDSIRQKLGHRLD------------LSNLIIKPVQRITKYELLIKEIIKATEGA 2097
             :.||  :..|....::.:..:|:            |.:|::.|:||:.||.||::|::|.|..
Mouse   285 -VESAISNLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTHD- 347

  Fly  2098 GLYKEVPM----LQEAYQQMKVVVKTVNDMM---VVLRSLQDFDGEI--TAQGSLLM---QGPMN 2150
                  ||    |:.|...||.:.:.||::.   ..||.::.|...|  ..|..||.   ||...
Mouse   348 ------PMEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGE 406

  Fly  2151 CVVDAAQKH--RELQVFLFQQIIIFADIEKTKNQYASPIFKYRSHIQLNHMQMKELGDC-RFQIR 2212
            ..:....||  :|..:|||...:|   :.|.|.               ::.:|||:.|. :::|.
Mouse   407 IRITTLDKHTKQERHIFLFDLAVI---VCKRKG---------------DNYEMKEIIDLQQYKIA 453

  Fly  2213 ---STDPKIPEMT---IICQAASQ---ENYAGWRDMLNKILQQ 2246
               :||.:..:.:   .:.....|   |.|...:|:..|.|:|
Mouse   454 NNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQ 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1455	CDD:459876
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2121	CDD:459876	46/195 (24%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061	30/134 (22%)
Vav3	NP_001365916.1	CH_VAV3	2..118	CDD:409113
		RhoGEF	193..369	CDD:238091	48/198 (24%)
		PH_Vav	383..506	CDD:269930	30/132 (23%)
		C1_VAV3	506..564	CDD:410419
		SH3_VAV3_1	596..657	CDD:212914
		SH2_Vav3	666..768	CDD:198270
		SH3_VAV3_2	819..874	CDD:212911