DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and arhgef25b

DIOPT Version :10

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_021332884.1 Gene:arhgef25b / 569561 ZFINID:ZDB-GENE-080225-17 Length:625 Species:Danio rerio


Alignment Length:702 Identity:187/702 - (26%)
Similarity:304/702 - (43%) Gaps:159/702 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1594 KSPAKHSGSSQRSSRDL----------DEQLTENDHDRCSL-------ASFGSGNTTDSDNKLGN 1641
            ||.||..|::::....|          ::|..:..::.|.|       :..|:|  .:::.:..|
Zfish     2 KSLAKLQGNTEQLLMSLSNTLPSLTLNNQQWIQEQNEGCLLLEEKQGCSKKGAG--PENEKQSWN 64

  Fly  1642 QEATWVVAD---YIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVS 1703
            |....:..|   |..| |.:::|:...      :||:|          :...||      |.|:|
Zfish    65 QRLEHIPEDKDSYTLT-GLSDVSLPPD------DPPSA----------SVSTDD------LSPIS 106

  Fly  1704 VLKPPPGSHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWLPLMNRKGT 1768
                 |.:|:..|...|:..|:          :|.::....|||..:|....|.|          
Zfish   107 -----PSNHQLFSSRRASVTST----------RSIKAFKRWLSSPVRRLSLGGGN---------- 146

  Fly  1769 DKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQPGASPATVLPSSQFPSSTQHPGGAGAGDYE 1833
                      |..|.|.:::|:........   ..|..||.:.:..||..:.:......|     
Zfish   147 ----------KSQSSKGIQSPEGSTYMFLP---LSPAQSPLSPMEKSQKLTRSYRSLDCG----- 193

  Fly  1834 PDEEVGLELPPPMKPIQEPHLIANGPPAFAKDAKESSGNM-----ASPGKMDGNPLSEIEEIVKT 1893
               |:..|..|     ..|:.     |.:..|..:.:.:.     .||...|           ||
Zfish   194 ---ELSRETSP-----DSPYY-----PRYLNDLFQRNQSFDVQTSVSPSLTD-----------KT 234

  Fly  1894 TTEQHESNSRVDGGGGVENASTNGHGRSHDNNDESHTAVSDKAAALKKRQCVFAELMSTEEAYVQ 1958
            ..||.:|                    ..||  |.|     :..||:|...|..||:.||:.||:
Zfish   235 LVEQSQS--------------------LEDN--EQH-----RRTALEKSIYVLTELVETEKLYVE 272

  Fly  1959 DLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFFLRALRNCQKSPADLGP 2023
            ||..:|.|||.    |.....:||.|: ||.|:||.||..||:||:|:||..|..|...|..|..
Zfish   273 DLGLVVEGYML----TMRSFGVPEYLE-GKDKIVFGNIHQIYDWHKDYFLGELEKCVSEPDLLAQ 332

  Fly  2024 LIKRSATKFALYYTYCSNKPLSEYIVSAHYQ-YFDSIRQKLGHRLDLSNLIIKPVQRITKYELLI 2087
            |..:...:..:|..||.|.|.||:|||.:.: ||:.:||:|||||.|::|:|||||||.||:||:
Zfish   333 LFIKHERRLNMYVVYCQNMPKSEHIVSEYIETYFEDLRQQLGHRLQLNDLLIKPVQRIMKYQLLL 397

  Fly  2088 KEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVNDMMVVLRSLQDFDGEITAQGSLLMQGPMNCV 2152
            |:.:|....||  ::...|:.|.:.|..|.|..||||.|.| ||.|:|::.|||.||.|.....:
Zfish   398 KDFLKYYTKAG--RQTEDLERAVEVMCFVPKRCNDMMNVGR-LQGFEGQLRAQGKLLQQDTFTFI 459

  Fly  2153 VD---AAQKHRELQVFLFQQIIIFADIEKTKNQYASPIFKYRSHIQLNHMQMKEL---GDCRFQI 2211
            .:   ...:.:|.:||||:|:||.::....|..::.|.:.|::.|:::.:.:::.   ..||..:
Zfish   460 ENENSILSRPKERRVFLFEQLIILSEPMDRKRGFSLPGYVYKNSIKISCLSIEDRCPEDPCRLVL 524

  Fly  2212 RSTDPKIPEMTIICQAASQENYAGWRDMLNKILQQQNDLIFMLSNPLSTKNK 2263
            .|.:........|.:|:|.|....|.:.:.::|:.|.:.:..|.:|:..:.|
Zfish   525 TSRNIDGSLQKFILRASSSEIRTSWANDIIQMLETQRNFLNALQSPIEFQRK 576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1455 CDD:459876
PH1_Kalirin_Trio_like 1462..1584 CDD:270060
SH3_Kalirin_1 1643..1707 CDD:212786 13/66 (20%)
RhoGEF 1945..2121 CDD:459876 77/176 (44%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 34/135 (25%)
arhgef25bXP_021332884.1 RhoGEF 258..429 CDD:238091 77/177 (44%)
PH-like 434..573 CDD:473070 36/139 (26%)
Blue background indicates that the domain is not in the aligned region.

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