DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and mcf2lb

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_009303050.1 Gene:mcf2lb / 569231 ZFINID:ZDB-GENE-081104-416 Length:1097 Species:Danio rerio


Alignment Length:1863 Identity:331/1863 - (17%)
Similarity:554/1863 - (29%) Gaps:855/1863 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ARDLLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNLGFTV 70
            |.|::|.|:.:..||:|||.:.|.|::.||..|....:..::.|.:|:||.||||.:|..:||.|
Zfish    44 AADVITELKRQFAFLSGGRAQDGSPIIIFPEYPSFCEIGDQEFRNVLTYLTSIPSLSAAGVGFIV 108

  Fly    71 IIDMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASI--SSHKYKFETTTV--- 130
            :||.|.:.  .|.:|..|..:...|.||:..|::::|....|:..:.:  ..|:..|:...:   
Zfish   109 VIDRRQDR--WTCLKGTLLRISGWFPANLRLVLVLRPSAILQRTLSDVFFKLHRDDFKVPVIMLS 171

  Fly   131 SIESLNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAED 195
            |:..|:..:|.:|||.:..|.|.|.|:.|...|..:|.|                          
Zfish   172 SVADLHTYIERNQLTQELGGSQYYCHKTWISHRTDLESF-------------------------- 210

  Fly   196 VPLARHAIDHHNEMRKKITKLPIEDLDMQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSAGQ 260
                                                                             
Zfish   211 ----------------------------------------------------------------- 210

  Fly   261 QSQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEKM 325
                                                                             
Zfish   211 ----------------------------------------------------------------- 210

  Fly   326 FDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVAARLIESQHYAAQ 390
                                                                           |.
Zfish   211 ---------------------------------------------------------------AA 212

  Fly   391 HIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQPLPSDIQSLE 455
            .:|.:||||....::.                                    |...|||:..:..
Zfish   213 LVKRMAQRLQVFGREL------------------------------------AETELPSNHLTAS 241

  Fly   456 TAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHRKNSNNGSFNKYERQN 520
            :.:.||                ||:|                                       
Zfish   242 SLLNTH----------------TSRK--------------------------------------- 251

  Fly   521 PAADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQEDVKQVLDWLKNHGEVFL 585
                                                       .:|:||:...|           
Zfish   252 -------------------------------------------DIFKEDMAGAL----------- 262

  Fly   586 RKNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGEADPNEIYSVARELELQ 650
                                           |..:|:|                           
Zfish   263 -------------------------------SQGRKIL--------------------------- 269

  Fly   651 VGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQ 715
                                                                  |.|.:..:|| 
Zfish   270 ------------------------------------------------------ENIREPVRRD- 279

  Fly   716 QESSVNVCLTTISQGEALLQEMRSLEYADNTGSIAALEATLEKLNKQKVELEELWSARKFRADLI 780
            .:||:|                     .|...::|.:...|.:||:.....:|.|...:.:.:|.
Zfish   280 PDSSLN---------------------PDQLENLATVHRLLSQLNESSTAFDEFWIQHQNKLELC 323

  Fly   781 LRLRYFERDARLLSVQMEMWSEELQHADLSRDYQKAEQLIRMHNESVTEIQNATYEVVQQGQDLL 845
            |::..||.:.:.|.                                 ||:..||        :.|
Zfish   324 LKVCQFEHNFQQLR---------------------------------TELDRAT--------ETL 347

  Fly   846 QLFENAGFISMADATHTAQARIEYLLDFLREREIDLEEMSEAKRAKLEQAVQLCQFQNDANQVIS 910
            ..|...|.         :.|:.|:||..|...|                 .::|:.   .::|.|
Zfish   348 NAFSAVGI---------SPAQTEHLLQELTNHE-----------------KKVCEV---LDRVRS 383

  Fly   911 WIRNGEAMLVASFVTPNSL-QEAEQLRKGHEQFQIAIEKTHTSAVQVKYRADALINANHYDPLSI 974
            .:..|:.::.:|.:..:|: .:..:|.|..|..                               .
Zfish   384 LVAEGQGLIDSSQILDDSIAAKCSELEKASENL-------------------------------T 417

  Fly   975 DEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCDGGGGSDKA 1039
            .|:.|..||               :|.:::.:|..:.:|.              |||.|      
Zfish   418 QELKDKQTK---------------LTQAMDLHKRLDMMCK--------------WCDDG------ 447

  Fly  1040 QAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQENQ 1104
                                                                             
Zfish   448 ----------------------------------------------------------------- 447

  Fly  1105 VLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEHNEFR 1169
               .:.|..:.||:||.    :..|:.|:..:    |.||.:.:..   .|.|...:.:|::...
Zfish   448 ---IYMLASQPLDKCQS----QEGAESALSEL----ECYLETANEK---QKWEISTVWQEYDNIL 498

  Fly  1170 STAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQ 1234
            :  .|.||:|....:...||.|........:|:..|...:..:..:...:|    |........:
Zfish   499 N--NELREQVTRAFEKKASLQEMFDRRRVSLKKLAAKQTRPVQPVAPSPES----LSSPAHRDHE 557

  Fly  1235 QLLLGSDGNS-----SISSSSGDRHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQT 1294
            .:.:..|.:|     .|:|...||.|             .|..::||:...|..:..:|.||::|
Zfish   558 SICISEDSDSRGSCKQINSDQVDRSS-------------RNASVSEEEETLAVLRRHVMNELLET 609

  Fly  1295 ERAYVNDLATCIKCFLEEFRA-------GKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKY 1352
            |||||.:|    .|.|:.:.|       ...:|:||..::||:|||::||::||::|||||||.|
Zfish   610 ERAYVEEL----MCVLQGYAAEMDNPSMAPLIPAALQNKKDVLFGNMQEIYNFHKRIFLRELETY 670

  Fly  1353 ETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGG-SFFEELQRRLEVDHPLPAYLIKPV 1416
            ...||.||.||:.|..:..:|..||.|||.|.:|..|... :||:|.|::||....|.:||:|||
Zfish   671 TDYPELVGRCFLDWMGELQIYEKYCHNKPRSESLWRQCSDCAFFQECQKKLEHKLGLDSYLLKPV 735

  Fly  1417 QRITKYQLLLKDLLSCCEESHG--EIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQ 1479
            |||||||||:|:::...:...|  |::..|..:|.:.|..||:|||..:...|.::..||.:::|
Zfish   736 QRITKYQLLIKEMIKYSKGCEGSVELQAALSSILGILKAVNDSMHLIAITGYDGNLGDLGRLLMQ 800

  Fly  1480 DAFQAW--------DTKQIIR-KGRERRVFLFELYLLFAKEVKES-----NVVKYQFKSKLMTTD 1530
            .:|..|        ...::.| |..:|.:||.|..|||.|..:||     ....|.||.:|....
Zfish   801 GSFSVWAEHKRGHVKVMELARFKPMQRHLFLHEKALLFCKRREESGEGYEKAPSYSFKQELSMAA 865

  Fly  1531 MGITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQ---ETCFSGTSLTL 1592
            :|||||.:||..||.:|:..    .|....::|.|.|.|.|||.::|:::.   |.|    ...:
Zfish   866 IGITEHAKGDSKKFEIWSSS----RDEVYTIQAASEEVKTIWVTEIRKLLTGQLEAC----KERI 922

  Fly  1593 PKSPAKHSGSSQRSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYIATSGS 1657
            .:.| |:..|.||:    .||.|               :.:.|.|:|...|.:.:.:|.:.....
Zfish   923 FEEP-KNEASQQRA----PEQFT---------------SESSSTNRLVRNERSSLKSDGVEKQKR 967

  Fly  1658 NELSVSKGQQVE-IVEPPTA--GEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTA 1719
            .|   .:|:::| |.|..||  .:.........|:..|  |:....|:..     |.|.:..|..
Zfish   968 EE---ERGKELESIFESRTAERAKGSSFSFETKPKRQD--VRSDPTPLET-----GPHPNLGGVR 1022

  Fly  1720 ANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWLPLMNRKGT---DKPPSSKPLVKKP 1781
            ..:.||.                    ..::|||     |:     ||:   |............
Zfish  1023 WFSTSSL--------------------FQSRRRG-----WM-----KGSLSLDASVEHDGYFSAE 1057

  Fly  1782 SEKNLRTPQKHAEELAEQQNQQPGASPATVLPSSQFPSSTQHP 1824
            .:.|....::..::|:|::.|     |..:....|....|:.|
Zfish  1058 EQANSDPEEEREDKLSEEEPQ-----PVRIDEEIQCFEETEEP 1095

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706 44/143 (31%)
SPEC 314..>468 CDD:238103 12/153 (8%)
SPEC 563..778 CDD:238103 21/214 (10%)
SPEC 782..997 CDD:238103 29/215 (13%)
SPEC 897..1119 CDD:238103 23/222 (10%)
SPEC 1125..1226 CDD:197544 18/100 (18%)
RhoGEF 1287..1456 CDD:279015 76/178 (43%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 42/138 (30%)
PH 1495..1580 CDD:278594 33/89 (37%)
SH3_Kalirin_1 1643..1707 CDD:212786 13/66 (20%)
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
mcf2lbXP_009303050.1 SEC14 50..193 CDD:214706 44/144 (31%)
SPEC 328..>473 CDD:321951 43/356 (12%)
RhoGEF 599..776 CDD:238091 76/180 (42%)
PH-like 783..914 CDD:327399 41/134 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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