DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and ngef

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_697546.3 Gene:ngef / 569090 ZFINID:ZDB-GENE-130530-794 Length:718 Species:Danio rerio


Alignment Length:577 Identity:128/577 - (22%)
Similarity:232/577 - (40%) Gaps:141/577 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  1129 AKQAIEWIHNTGEAYLSSRSNLVG------------ISKEETEGLLKEHNEFRSTAKETRERVKL 1181
            ::..|..:.|..:..:.|||.|..            :|:..|.....:.|:..|||.......: 
Zfish   109 SRSGISLLSNGVQGGVRSRSPLASPGDWPRRLEMEELSERTTSACTMQDNDNHSTADPDNITFR- 172

  Fly  1182 LIQLADS---LVEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGN 1243
            |::..||   :..:...|..:|.:.|..:.|.|:|.|.         ::.:...:|:..|.:.|:
Zfish   173 LVRNGDSPQKMAVENSCHNLNIMKNVDVLYQEYRDTSK---------QQEIDQRRQRDGLPTAGS 228

  Fly  1244 SSISSSSGDRHSDPTLEAKLNSS-NKEN--KEINEEKR----KSARRKEFI----MAELMQTERA 1297
            ..:::        |.|:.:|.|| |..|  :.::..|:    ::...||.|    |.||:.:|.:
Zfish   229 GVLAA--------PALQLQLRSSTNSLNLWQNLDAVKKSGLLQTLEPKEIILQEAMFELVTSEAS 285

  Fly  1298 YVNDLATCIKCFLEEFRAGKSVPSAL--IGQEDV--IFGNIKEIHHFHQKIFLRELE---KYETM 1355
            |...|......||..       |..:  :.|.|:  :|.||.:|....:| ||.:||   :...:
Zfish   286 YYKSLELLETHFLRN-------PLLVNTLSQSDMHFLFSNITDIMKASEK-FLMDLEHRIEESIL 342

  Fly  1356 PEDVGHCFVTW---ASKFDMYVHYCKN---KPTSNNLLVQHGGSFFEE---LQRRLEVDH-PLPA 1410
            ..||  |.:..   .:.|.:::.|..|   :.|:...::|...:|.|.   |:.:.:|.. ...:
Zfish   343 ISDV--CDIVHFHAVNHFQVFISYVINQVYQETNYRRILQENCAFRENMAILENQPKVKGLSFTS 405

  Fly  1411 YLIKPVQRITKYQLLLKDLLSCCEE----------SHGEIKEGLEVMLNVPKKAND-AMHLSLLE 1464
            :||.|.||||:.:||::::|...||          :|.|:::       :.|:.|: |..:|..|
Zfish   406 FLILPFQRITRLKLLVQNILKRVEENSEKERTAILAHQELEK-------IVKQCNEGARKMSRTE 463

  Fly  1465 NCDVSVDKLGEVVLQDAFQAWDTKQIIRKG--------------RERR------VFLFELYLLFA 1509
            .. :|::|..|...:.......::.:::||              |.|:      :|||...||..
Zfish   464 EL-ISIEKTLEFKSKSVPVISHSRWLLKKGEVQQMSGPKSTRTMRSRKLYHPIYLFLFNNLLLIT 527

  Fly  1510 KEVKESNVVKYQF-----KSKLMTTDMG----------ITEHIEGDETKFAVWTGRSPMLSDCRI 1559
            |  :.|:..|:|.     :|.|.|.|:.          :.:.:|..|.:            :...
Zfish   528 K--RNSSGDKFQVLDSCSRSMLRTEDLEDQGQMLACVFVLKLLENQEDR------------EVSY 578

  Fly  1560 VLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDLDEQLTE 1616
            :||..|:..|..|:..|.. .:.|.|..||...|.||......|. ||::.||...|
Zfish   579 MLKTESVSDKLRWICALTP-NRRTRFLSTSTHEPDSPQVQCIQSY-SSQEPDELSVE 633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544 22/111 (20%)
RhoGEF 1287..1456 CDD:279015 48/199 (24%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 29/156 (19%)
PH 1495..1580 CDD:278594 23/105 (22%)
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
ngefXP_697546.3 RhoGEF 275..454 CDD:279015 47/195 (24%)
PH_ephexin 475..601 CDD:269929 25/140 (18%)
SH3 615..668 CDD:302595 6/20 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3601
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.030

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