DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and arhgef16

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_005167338.1 Gene:arhgef16 / 567180 ZFINID:ZDB-GENE-081104-446 Length:662 Species:Danio rerio


Alignment Length:542 Identity:123/542 - (22%)
Similarity:208/542 - (38%) Gaps:139/542 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1127 RSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVE 1191
            :|.:.||..:|..||....|      :|....|.::......:|..|.|..|:            
Zfish   124 KSYRAAITSLHLDGELQPES------LSPVSDEKVVSPKQANKSGRKRTLGRI------------ 170

  Fly  1192 KGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLGMS-----QQQLLLGSDGNSSISSSSG 1251
            :...||...|.     :.|:         |.|..|:.|.:|     :::|           |..|
Zfish   171 RNRKHAGSFKD-----EPRF---------YQEIKERGLNVSSLSTEEEEL-----------SPVG 210

  Fly  1252 DRHSDPTLEAKLN--------SSNKENKE------INEEKRKSARRKEFIMAELMQTERAYVNDL 1302
            ....|..:..| |        |...:.|:      |..|:||   |:|.|. |::.:|.:|.:.|
Zfish   211 PPGEDQGIVVK-NYRAAYITWSQLPQVKDLGILDFITPEERK---RQEVIF-EIITSEYSYQHSL 270

  Fly  1303 ATCIKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEK-YETMP--EDVGHCFV 1364
            :..::.|.:.....|::.:.   :...:|.||..|... .|.|..:|:| ::..|  |.:.....
Zfish   271 SILVRHFKDSVDLRKTMTAT---EHHHLFSNISVIQDV-SKRFFEDLDKRHQANPVIERISDIVA 331

  Fly  1365 TWASK-FDMYVHYCKNKPTSNNLL--VQHGGSFFEELQRRLEVDH-----PLPAYLIKPVQRITK 1421
            |:|:| |:.|:.||.|:......|  :....|.|.|..:::|...     |:.::||.|:||:|:
Zfish   332 TYATKHFEPYIVYCSNETFQQRTLQKLLSSNSAFRETLKQIETSEDCGGLPMLSFLILPMQRVTR 396

  Fly  1422 YQLLLKDLLSCCEESHGEIKE------GLEVMLNVPKKAND-AMHLSLLENCDVSVDKLGEVVLQ 1479
            ..||:..:   ||::..|..|      ..:.:..:.|..|| |..:...|.. .::.|..|....
Zfish   397 LPLLMDTI---CEKTTKETAEYYKACWAFKAISKLVKSCNDGARRMERTEQM-YTIQKQMEFGKI 457

  Fly  1480 DAFQAWDTKQIIRKGRE-----------RRVFLFELYLLF---------AKEVKESNVVKYQFKS 1524
            ..|....:.:.::|..|           |:.|.|:.|.||         .|:.:||.||      
Zfish   458 KPFPLVSSSRWLKKSGELAVYTDDLSIFRKAFSFKSYYLFLFNDVLIVTKKKSEESYVV------ 516

  Fly  1525 KLMTTDMGITEHIEGDE----TKFAVWTGRSPMLSDCR---IVLKATSLETKQIWVKKLREVMQE 1582
                .|....|.:|.:|    :|..:....:|. ||.|   :||.|.:...:..||..||:|.|.
Zfish   517 ----LDYATVEKVEVEEEMSDSKLNLKLMMNPN-SDGRSEQLVLVAENKLVRAQWVTALRDVKQT 576

  Fly  1583 TC--------FSGTSLTLPKSP 1596
            :.        :..|...|||:|
Zfish   577 SSIDNDDLPQYEATKAYLPKAP 598

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544 19/98 (19%)
RhoGEF 1287..1456 CDD:279015 44/185 (24%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 35/148 (24%)
PH 1495..1580 CDD:278594 28/111 (25%)
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
arhgef16XP_005167338.1 RhoGEF 255..434 CDD:279015 44/186 (24%)
PH_ephexin 456..577 CDD:269929 32/131 (24%)
PH 469..574 CDD:278594 29/115 (25%)
SH3_ARHGEF16_26 586..639 CDD:212871 5/13 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3601
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.030

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