Protein Alignment trio and LOC5667805

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_061512102.1
• Gene: LOC5667805 / 5667805
• VectorBaseID: AGAMI1_004950
• Length: 1099
• Species: Anopheles gambiae
• Alignment Length: 757
• Identity: 144/757 - (19%)
• Similarity: 256/757 - (33%)
• Gaps: 277/757 - (36%)

  Fly  1711 SHKHGS-----GTAANAASSAGS--QKSDMQDQSNR-----------------SKADALSSSTKR 1751
            |.::|:     |....|.|||.|  :|.::..:..|                 ||.:..::.|..
Mosquito     2 SARYGTISGMLGLVEPAESSAASSMEKIEVLPEPARRTRKRDSLRKISVRHLVSKLETRAAETLE 66

  Fly  1752 RGFSGRNWLPLMNRKG----------TDKPPSSKPLVKKPSEKNLRT----PQKHAEELAEQQNQ 1802
            |.|.||  .....|||          |.......|:..:||..:.||    |.. |::.:..|:.
Mosquito    67 RNFGGR--FSGRVRKGKLEDEATPSATSSSSGGVPVPDQPSSSSARTWYMVPLS-AQKSSSNQSA 128

  Fly  1803 QPGASPATVLPSSQFPSSTQHPGGAGAGDYE--------------------PDEEVGLELPPPMK 1847
            ...|:.:::..||...:...:...:...|.:                    ..||.|::..|
Mosquito   129 DCSAAASSLSLSSSMATDDNNSDNSDDTDVQWAVIGRDKISADTAEFSQRLSTEEAGMKKTP--- 190

  Fly  1848 PIQEPHLIANGPPAFAKDAKESSGNMASPGKMDGNPLSEIEEIVKTTTE-----------QH--- 1898
                      |.|..   .:|.||..:.....:.:.|.:::::..|..|           :|
Mosquito   191 ----------GTPTV---DREDSGRWSICSDFERDSLPDVDDVCDTWNEFIYLRLSEENAKHLNS 242

  Fly  1899 ------------------ESNS------------RVDGGGGVENASTNGHGRSHDNNDESHTAVS 1933
                              .||:            |:..|..:.:.| |.....||::.:|||:.|
Mosquito   243 YSPDFEVTPFDEYYQPAEASNTIISLRFTPYELHRILHGYDLIDLS-NDDEDDHDDDVQSHTSHS 306

  Fly  1934 ----------------------------DKAAALK------------------KRQCVFAELMST 1952
                                        |:..|.:                  |...:..||:.|
Mosquito   307 STDSDSVFVDAFVQHPTDVRITPSVDSLDEGVAFRDSPVESPEPHHLPNDIDIKISFLIEELLDT 371

  Fly  1953 EEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFFLRALRNCQKS 2017
            |..|:..|.:   |..|.|:...:| ..|.:|.|.|..| |.|::.||.:||:.||..|...
Mosquito   372 ERNYINTLEK---GIATYIDAVFTD-QTPPELCGKKYHL-FGNLQYIYRFHRNAFLPRLLTA--- 428

  Fly  2018 PADLGPLIKRSATKFAL---------YYTYCSNKPLSEYIVSAHYQYFDSIRQKLGHRLDLSNLI 2073
                |..::..|..|..         |..|....|.|:.:...|.::|...:|:.|.:|.:.:||
Mosquito   429 ----GNDVELIADAFVHFLDNDSFYGYVLYSMYHPKSQRLCEQHIEFFRQHQQQHGDKLGVKSLI 489

  Fly  2074 IKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVK---------------TVNDM 2123
            ::|:||:.:|:||:..:.|.     |.|:...:....|..||.|.               ||||:
Mosquito   490 LQPIQRLPRYQLLLTSLFKQ-----LVKKPGAISRNTQLHKVCVAEKRLQTLIGIMNESVTVNDI 549

  Fly  2124 M--------------------VVLRSLQDFDGEI-------------TAQGSLLMQGPMNCV--- 2152
            :                    :|||: |:.|.::             ....::|.||....|
Mosquito   550 LQCEKAEDDEVELGFGVPKPAIVLRN-QNHDNQVLFLYPKDNEHVDHNKPINILHQGKFRSVFPV 613

  Fly  2153 -VDAAQKHRELQ--VFLFQQIIIFADIEKTKNQYASPIFKYRSH-------IQLNHMQMKELGDC 2207
             ::..:..|:.|  :|:|::.:|:.:....|:      ..||.|       ....:.|:.:|...
Mosquito   614 FINDLRLKRQYQGRLFVFERCVIYTEQLDLKS------LTYRGHYTHQEVEFDFTNRQILKLSSR 672

  Fly  2208 RFQIRSTDPKI----------PEM-----TIICQAASQENYA 2234
            |.:....:.|:          |::     |||.:...:|::|
Mosquito   673 RHERLEIEVKVNIQSPGKTHLPDVMMAIKTIIDRRDQRESFA 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1455	CDD:459876
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2121	CDD:459876	52/199 (26%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061	25/146 (17%)
LOC5667805	XP_061512102.1	None