DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trio and LOC559907

DIOPT Version :9

Sequence 1:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster
Sequence 2:	XP_009303604.1	Gene:	LOC559907 / 559907	-ID:	-	Length:	1046	Species:	Danio rerio

Alignment Length:	1100	Identity:	257/1100 - (23%)
Similarity:	443/1100 - (40%)	Gaps:	249/1100 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   749 IAALEATLEKLNKQKVELEELWSARKFRAD-LILR--LRYFERDARLLSVQMEMWSEELQHADLS 810
            :::|...|..:::.::..|...|..:..:| ::||  :..|....:.::..::.:..||...:|.
Zfish    61 LSSLSDLLRFIDENQLSTEFGGSLEQCHSDWIVLRTAIESFAVTVKEIAQLLQTFGTELSEIELP 125

  Fly   811 RDYQKAEQLIRMHNESVTEIQNATYEVVQQGQDLLQLFENAGFISMADA----THTAQARIEYLL 871
            .|....|.|:|.|.|...::::....|:::|:.||...|.:..:..|.|    ....:.|::.|:
Zfish   126 DDASGIEYLLRSHTEKYRQMKDDIRSVMREGRQLLSNLEASKAVEGAAAEDRDISQDKERVQRLV 190

  Fly   872 DFLREREIDLEEMSEAKRAKLEQAVQLCQFQNDANQVISWIR--NGEAMLVASFVTPNSLQEAEQ 934
            ..||:.|:..:...|....||:|.:||.|::...:::.:.:.  |.:...:||..|  ::.:.||
Zfish   191 AQLRDMEMAFDGFFEKHHLKLQQYLQLLQYELSFHEMEAILEKLNIQEKAIASVGT--TVAQTEQ 253

  Fly   935 LRKGHEQFQIAIEKTHTSAVQVKYRADALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKLV 999
            |.|..|..:...|.....|..:......|..::||....|.:..:::......|.|....:...:
Zfish   254 LLKDLEMLENTAEDEMGRAQIIILHGHQLAASHHYALALIVQRCNELRHHCDTLTTALRAKRASL 318

  Fly  1000 TASINFYKTAEQVCSVLDSLEREYKREDDWCDGGGGSDKAQAIVQLISKHQEQKEAFLKACTLAR 1064
            |          ::..:|..||...:    |||.|                     |:|.|
Zfish   319 T----------RIRDLLLRLEETVR----WCDEG---------------------AYLLA----- 343

  Fly  1065 RTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSA 1129
                                                  ||:||.:..::.:           ::|
Zfish   344 --------------------------------------NQLLDKFQSKEGA-----------QAA 359

  Fly  1130 KQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKL---LIQLADSLVE 1191
            .:.||.:..|..:.|  |||| .|...|.:.:|..  :.:|..:...|:|..   :||...:.:.
Zfish   360 LRDIETLMETAPSVL--RSNL-DILNLEFQAVLTP--QLQSQIESVTEKVSTVQGMIQSRQACLR 419

  Fly  1192 KGHAHASDIK----QWVA---SVDQRYKD--FSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSIS 1247
            |    .:||:    |.||   ....|.|.  ||.:   :...:..||..|....|.|
Zfish   420 K----LADIQVRPIQLVAPRPETSPRCKSPLFSPK---HSFDVNSSLRFSFDLALPG-------- 469

  Fly  1248 SSSGDRHSDPTLEAKLNSSNKENKEI----NEEKRKSARRKEFIMAELMQTERAYVNDLATCIKC 1308
             ....|....|.:.::....:||:..    .|......:.|..:|.||::|||.||.:|.:.:..
Zfish   470 -KKASRKGPNTKKIEVMHDYEENRSCLSYGPEGVENPDQHKRRVMKELIETERIYVEELMSVLLG 533

  Fly  1309 FLEEF---RAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKF 1370
            :..|.   .....:||.|..:::.:|||:.||:.||.:|||::||.....||.||..|:.....|
Zfish   534 YRAEMDNPALSNILPSVLRNKKEDLFGNLPEIYKFHSRIFLQDLESCLETPERVGARFLERKEHF 598

  Fly  1371 DMYVHYCKNKPTSNNLLVQHGGS-FFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCE 1434
            .:|..||:|||.|:.|..|...| |.:|.:.:|:....|.:||:|||||:||||||||:||....
Zfish   599 QVYERYCQNKPRSDALWRQCSDSAFIQECKGKLDHKLGLDSYLLKPVQRLTKYQLLLKELLKHSS 663

  Fly  1435 ESH--GEIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAW--------DTKQ 1489
            .|.  .|::..|..||::.|..||:||...:...:..:..||.|::|.:|..|        ..|.
Zfish   664 NSQYASELQGALNAMLDLLKSVNDSMHQISITGYEGELSDLGRVLMQGSFNVWINHKKGPTRMKD 728

  Fly  1490 IIR-KGRERRVFLFELYLLFAKEVKES-----NVVKYQFKSKLMTTDMGITEHIEGDETKFAVW- 1547
            :.| |..:|.:||.|..|||.|:.:|:     ....|.||..||.:.:||||:::||..||.:|
Zfish   729 MARFKPMQRHLFLHERALLFCKKREETGEGHDRTASYSFKHCLMMSAVGITENVKGDVKKFEIWY 793

  Fly  1548 TGRSPMLSDCRIVLKATSLETKQIWVKKLREVM---QET-------------------------- 1583
            .|:..:     .|::|.:::.|..|:.::|:::   |:|
Zfish   794 NGKEEV-----YVVQAPTVDVKIAWLTEIRKILNNQQKTVKGDSQPDREQPLSPPLADSVRHISV 853

  Fly  1584 C--FSGTSLT--------LPKSPAKHSGSSQRSSRDLDE-----QLTE--------NDHDRCSLA 1625
            |  :|.|.:|        ||.|  ||.|:|. ||.:.|.     .||:        .:|:|.|..
Zfish   854 CMPWSATQITGCSGCFDVLPHS--KHQGASV-SSEEADSGRVSPVLTDPVIISPRPRNHNRRSWP 915

  Fly  1626 SFGS---------------GNTTDSDNKLGNQEATWVVADYIA-----TSGSNELSVSKGQQVEI 1670
            ....               .|.:|||.:   .:...|...|.|     ..|.:::.:..|..:.:
Zfish   916 GTSHSVDICEGLEDWTTDLSNISDSDEE---DDVLLVPGRYRAMLDHLKCGKDDVIIKCGDVIHV 977

  Fly  1671 VEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQK 1730
            ::....|        |....:.....||.:||..|....|.........:..|.:..|:|
Zfish   978 LQESVMG--------LWHVKNLTRGGEGKLPVDTLLRMLGDAGRSPSIQSGGAGNINSRK 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103	4/28 (14%)
		SPEC	782..997	CDD:238103	47/222 (21%)
		SPEC	897..1119	CDD:238103	35/223 (16%)
		SPEC	1125..1226	CDD:197544	27/112 (24%)
		RhoGEF	1287..1456	CDD:279015	68/174 (39%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	40/165 (24%)
		PH	1495..1580	CDD:278594	29/90 (32%)
		SH3_Kalirin_1	1643..1707	CDD:212786	12/68 (18%)
		RhoGEF	1945..2122	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
LOC559907	XP_009303604.1	SEC14	<20..85	CDD:326643	4/23 (17%)
		SPEC	119..318	CDD:321951	44/200 (22%)
		SPEC	224..415	CDD:238103	49/286 (17%)
		RhoGEF	509..686	CDD:238091	69/176 (39%)
		PH-like	693..824	CDD:327399	38/135 (28%)
		SH3	952..1005	CDD:327375	10/60 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910