Protein Alignment trio and arhgef6

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_068069464.2
• Gene: arhgef6 / 558288
• ZFINID: ZDB-GENE-101013-2
• Length: 799
• Species: Danio rerio
• Alignment Length: 1039
• Identity: 183/1039 - (17%)
• Similarity: 331/1039 - (31%)
• Gaps: 350/1039 - (33%)

  Fly  1040 QAIVQLIS--------KHQEQKEAFLKA--------CTLARRTAETFLKYANRSQQCYQYKGNCE 1088
            |.:..||:        |:....|.|||.        |.|..|.....:...:...:|   :.:|.
Zfish     6 QTVTWLITLGVLNSPKKNIADPEEFLKTSLRDGVVLCKLIERVLPGAITKYSAEPKC---EADCI 67

  Fly  1089 GHVKSKL-------------DKLLTQE--NQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHN 1138
            .:::..|             :.|.:.|  |:||...:....:...|      .||..|:     |
Zfish    68 ANIREFLKGCQSLKVEGFDAESLYSGENFNRVLSTLSAINIATQDC------SRSCPQS-----N 121

  Fly  1139 TGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQW 1203
            |..:.||:.|        :....||.....|..:|            |..:.|.|......:|
Zfish   122 TSTSSLSTPS--------QAAPTLKSSRSLRRQSK------------AVEMSENGGGGQLVVK-- 164

  Fly  1204 VASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNSSNK 1268
                 .|:....|..|.......:.:.:::|:  .|.....:::|.:|...|:...|.|......
Zfish   165 -----ARFNFKQNNEDELSFSKGELIHVTRQE--EGGWWEGTLNSKTGWFPSNYVREVKPCDKPI 222

  Fly  1269 ENKEIN--EEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDVIF 1331
            ..|.|.  :..:.:......::.::::.||.:|.:|...:..:|...:|...:.|.....   :.
Zfish   223 SPKAIKGFDVPQLTKNYYSVVVQDILEHEREFVKELQNVLGGYLRPLQASDKLSSVDCSS---LN 284

  Fly  1332 GNIKEIHHFHQKIFLRELEKYETMPED---VGHCFVTWASKF-DMYVHYCKNKPTSNNLLVQHGG 1392
            ||:::|..|.|.:.| .||:...:||.   :|.|::....:. .:|:.||.:.|::..:|..|.
Zfish   285 GNLEDILSFQQGLCL-TLEECSKVPEGQQRIGGCYLNMMCQIRTLYLSYCSSHPSAVCVLTDHS- 347

  Fly  1393 SFFEELQRRLE---VDHP----LPAYLIKPVQRITKYQLLLKDLLSCCEESHGEIKEGLEVMLNV 1450
               |||.:.:|   ...|    |...|.||..|:.||..||::|....||:|.:..:.|:.....
Zfish   348 ---EELDKFMESQGASAPGILTLTTSLSKPFMRLDKYPTLLQELERHVEEAHPDYSDILKATAAF 409

  Fly  1451 PKKANDAMHLSLLENCDV-------------SVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLF 1502
            .........|...:|.::             |:..||:|:......   .:....:.:|.|.|:.
Zfish   410 KNLVTQCQDLRKRKNLELQILSEPVRGWEGDSMKSLGQVIYMSQIH---MQSSANEEKEERYFML 471

  Fly  1503 --ELYLLFAKEVKESNVVKYQFKSKLMTTDMGITEHIEGDET---KFAVWTGRSPMLSDCRIVLK 1562
              .:.::.:...:.|..:   ::.:|..|...:|:..|..||   .|.:..|     |..|.::.
Zfish   472 FPNVIIMLSASPRMSGFI---YQGRLPLTGTSVTKQPEDAETGHYAFEITGG-----SIDRTMVF 528

  Fly  1563 ATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDLDEQLTENDHDRCSLASF 1627
            .:||:.:|.|::.|...:
Zfish   529 CSSLQEQQDWLEHLHPYI----------------------------------------------- 546

  Fly  1628 GSGNTTDSDNKLGN--QEATWVVADYIA------TSGSNELSVSKGQQVEIVEPPTAGEPDFCLV 1684
                      |:|:  :....|:|.:.|      .|.||.:.:...|.|: |:|.|.
Zfish   547 ----------KVGSPFETVLKVIAFFAAFTSIQLNSKSNVMFLCILQSVD-VKPLTM-------- 592

  Fly  1685 RLNPQHDDAAVQEGLVPVSVLKPPPGS---HKHGSGTAANAASSAGSQKSDMQDQSNRSKADALS 1746
                                    ||:   |.||.||.|
Zfish   593 ------------------------PGTSSHHLHGFGTTA-------------------------- 607

  Fly  1747 SSTKRRGFSGRNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQPGASPATV 1811
                                 .::.|...|.:.||...:...|             .|...|:..
Zfish   608 ---------------------VNRGPLEPPKITKPWSLSCLRP-------------APPLKPSAA 638

  Fly  1812 LPSSQFPSSTQHPGGAGAGDYEPDEEVGLELP---PPMKPIQEPHLIANGPPAFAKDA------- 1866
            |...:..|.:..|             :...||   ...||..:..|:.....|..:||
Zfish   639 LGYKEDSSKSPRP-------------IKKFLPKRKTERKPSDDEFLLRKSTAALEEDAQILKVIE 690

  Fly  1867 ---------KESSGNMASPGKMDGNP---LSEIEEIVKTTTEQHESNSRVDGGGGVENASTNGHG 1919
                     :.::|.|.|..| :..|   |.|.|:|:                  ||:..:||..
Zfish   691 AYCTGASLHQSTTGFMFSVRK-ECVPQVLLPEEEKII------------------VEDIKSNGQT 736

  Fly  1920 RSHDNN-DESHTAVSDKAAALKK-----RQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSD 1977
            ...:.: .::..|:.|:...|||     :||:..|..|.:|     |..:|.....:.|:.:.|
Zfish   737 TIEEKSLVDAVYALKDEVHELKKENKWMKQCLEEEQKSRKE-----LERVVRKLAKQKNDCSWD 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103	19/109 (17%)
		SPEC	1125..1226	CDD:197544	19/100 (19%)
		RhoGEF	1287..1455	CDD:459876	44/178 (25%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	24/139 (17%)
		SH3_Kalirin_1	1643..1707	CDD:212786	11/69 (16%)
		RhoGEF	1945..2121	CDD:459876	7/33 (21%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
arhgef6	XP_068069464.2	None