DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and trioa

DIOPT Version :10

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_021323750.1 Gene:trioa / 557667 ZFINID:ZDB-GENE-060503-334 Length:3115 Species:Danio rerio


Alignment Length:2374 Identity:1016/2374 - (42%)
Similarity:1454/2374 - (61%) Gaps:224/2374 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 RARDLLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNLGFT 69
            :|.::|.:|:|:|.||:||||:||||:|.||:....||::.||||||::||..|||:.....|||
Zfish    53 KAMEVLPILKEKVAFLSGGRDKRGGPVLTFPSRTNHDRIRHEDLRRLIAYLAGIPSEDVCKHGFT 117

  Fly    70 VIIDMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKYKFETTTVSIES 134
            ||:||||:.  ..::|.:||:|||.|...||..:||||||||||||.:..|.|::||||.||:|.
Zfish   118 VIVDMRGSK--WDSIKPLLKILQESFPCCIHIALIIKPDNFWQKQRTNFGSSKFEFETTMVSLEG 180

  Fly   135 LNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDVPLA 199
            |:|:|:..|||.||||...|:|::|.:.|:|.|||...|..:..|::::.|.:.|.|..:|:..|
Zfish   181 LSKVVDPSQLTADFEGSLDYNHEEWIEIRVAFEDFTGNARHLLARLEEMHETVTRKDLPQDLDGA 245

  Fly   200 RHAIDHHNEMRKKITKLPIEDLDMQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSAGQQSQP 264
            |..|:.|..::|::.|.|:|::|.:|::||.:|        |:..:.....:...|.....|.||
Zfish   246 RRMIEEHAALKKRVIKAPVEEVDNEGQRLLQRI--------QSSESYANRTVPVPPGQREGQGQP 302

  Fly   265 SQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEKMFDWI 329
                     |.|....|.:....:|.:|:.::.|...|..:|::||||||.||||||.|||||||
Zfish   303 ---------NADTQGLVPRITALLEKLHSTRQNLHQSWHIRKLQLDQCFQLRLFEQDAEKMFDWI 358

  Fly   330 LHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVAARLIESQHYAAQHIKT 394
            :||:.:|...|.|||:|:..|..||.:|..||:..|||.|||:||::|..||:|:.|||:|.||.
Zfish   359 MHNKGLFLAGYTEIGNNHPHAMELQTQHNHFAMNCMNVYVNINRIMSVGNRLLEAGHYASQQIKQ 423

  Fly   395 LAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQPLPSDIQSLETAIR 459
            ::.:|::.||.|||.||||:|:|::|..||.|.:||.::|.||..|| ....|||::|.||.||.
Zfish   424 ISGQLEQEWKAFAAALDERSALLEMSATFHQKCDQYMSNVDSWCKAC-GEVDLPSELQELEDAIH 487

  Fly   460 THQSLYEAMCQAYTEVHSTS-----KKLLYQLDH---------LVQVCNQPPPPGVPDHRKNSNN 510
            .||.|||.:..||:||.|.:     .:..::..|         |:....:|..||..|....|  
Zfish   488 HHQGLYEHITAAYSEVQSRAAPNHYSERAFKRTHLEVSQDGKALLDKLQRPLTPGSADSLTAS-- 550

  Fly   511 GSFNKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQEDVKQVLD 575
                        |:|::..:|||.:||::|.|.|.||..|...::||||.|.|.:||:||:||||
Zfish   551 ------------ANYTKAVNHVLDIIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLD 603

  Fly   576 WLKNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGEADPNEI 640
            |::||||.||.|:||:|::.|:||..|..|::||.||||||:||.|||.||::||::||.||.||
Zfish   604 WIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEI 668

  Fly   641 YSVARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIE 705
            |..|.:||.::..|..|||||:..|||:|.|:||.|::..|:::|:.::..|   :..|::|.::
Zfish   669 YQAAHQLEDRIQDFVRRVEQRKVLLDMSVAFHTHVKELWTWLEELQKELLDD---VYAESVEAVQ 730

  Fly   706 RILQQYQRDQQESSVNVCLTTISQGEALLQEMRSLEYADN----TGSIAALEATLEKLNKQKVEL 766
            .:::::.: ||::::...:..|.:||.|:|::|.|..:.|    ..||..:|:.|::|::.:.::
Zfish   731 DLIKRFGQ-QQQTTLQFTVNVIKEGEDLIQQLRDLAISSNKTPHNSSINHIESVLQQLDEAQAQM 794

  Fly   767 EELWSARKFRADLILRLRYFERDARLLSVQMEMWSEELQHA----DLSRDYQKAEQLIRMHNESV 827
            |||:..||.:.:|.|:||.|||||..:...::.|:|||...    | :.|...|||.::.|.:..
Zfish   795 EELFQERKIKLELFLQLRIFERDAIDIISDLDSWNEELSQQMNEFD-TEDLTLAEQRLQHHADKA 858

  Fly   828 TEIQNATYEVVQQGQDLLQL---FENAGFISMADATHTAQARIEYLLDFLREREIDLEEMSEAKR 889
            ..:.|..:.|:.|||:|||.   .:.:|...:.|.......|::.||:||.|::.:|:..:|..|
Zfish   859 LTMNNLAFHVIHQGQELLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDVAAEQHR 923

  Fly   890 AKLEQAVQLCQFQNDANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIEKTHTSAV 954
            ..|||.|||...|.:..||:.||||||:||.|..:|.:||||||||::.|||||.||||||.||:
Zfish   924 RHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSAL 988

  Fly   955 QVKYRADALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSL 1019
            ||:.:|:||:.|||||...|.:.:::|...||||:...|:|.|||.||:.||||:|||||||:||
Zfish   989 QVQQKAEALLQANHYDMDMIRDCAENVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESL 1053

  Fly  1020 EREYKREDDWCDGGGGSDK------AQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQ 1078
            |:|||||:|||   ||:||      :..:..:||||.|||||||||||||||.|:.||||.:|:.
Zfish  1054 EQEYKREEDWC---GGADKLGPNCESDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYMHRNS 1115

  Fly  1079 ----QCYQYKGNCEGHVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNT 1139
                ....:....|..||:.|::||.:||:||.:||:||:.||||||:|:||||||||:||||:|
Zfish  1116 VSMPGMLSHVKAPEQQVKNILNELLQRENRVLHFWTMRKRRLDQCQQYVVFERSAKQALEWIHDT 1180

  Fly  1140 GEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWV 1204
            ||.|||:.:: .|.|...|:.|||||.:|..|||:|:|||||||||||...:|||:||::||:||
Zfish  1181 GEFYLSTHTS-TGSSIHHTQELLKEHEDFHITAKQTKERVKLLIQLADGFCDKGHSHAAEIKKWV 1244

  Fly  1205 ASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSD------PTLEAKL 1263
            .:||:||:|||.|||.|...|||:||:|       ||.|    .:|.|...|      |..|.||
Zfish  1245 TAVDKRYRDFSLRMDKYRTSLEKALGIS-------SDSN----KASKDLQLDIIPASAPGSEVKL 1298

  Fly  1264 NSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAG-KSVPSALIGQE 1327
            ..:   ..|:|||||||||||:||||||:|||:|||.||..|:..:|.|..:| :.:|..::.:|
Zfish  1299 RDA---AHELNEEKRKSARRKDFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKE 1360

  Fly  1328 DVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGG 1392
            .:||||:::::.||..|||:||||||.:||||||||||||.||.|||:||||||.|..|:::|.|
Zfish  1361 HIIFGNMQDLYEFHHNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVNYCKNKPDSTQLILEHAG 1425

  Fly  1393 SFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEESHGEIKEGLEVMLNVPKKANDA 1457
            .:|:|:|:|..:.:.:.:|||||||||||||||||:||:||||..||||:||||||:|||:||||
Zfish  1426 GYFDEIQQRHRLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDA 1490

  Fly  1458 MHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVKESN-VVKYQ 1521
            ||||:||..|.:::..||::||:|||.||.|.:|||||||.:||||:.|:|:||||:|| ..||.
Zfish  1491 MHLSMLEGFDENIESQGELILQEAFQVWDPKTLIRKGRERHLFLFEMSLIFSKEVKDSNGRSKYI 1555

  Fly  1522 FKSKLMTTDMGITEHIEGDETKFAVWTGRSPMLSDCRIVLK----------ATSLETKQIWVKKL 1576
            :||||.|:::|:|||:|||..|||:|.||:| .||.:||||          |:.:|.||.|:|.:
Zfish  1556 YKSKLFTSELGVTEHVEGDPCKFALWVGRTP-TSDNKIVLKLSQGCKHGSLASGIENKQDWIKHI 1619

  Fly  1577 REVMQETC--FSGT---SLTLPK-SPAKHSGS--SQRSSRDLDEQLT-ENDHDRCSLASFGSGNT 1632
            |||:||..  ..|.   .:.:|| |.|||.|.  :.|...|||.|.. .:..|..||||..|.||
Zfish  1620 REVIQERTVHLKGALKEPIHIPKASTAKHKGRRYTPRDGEDLDSQGDGSSQPDTISLASRTSQNT 1684

  Fly  1633 TDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQE 1697
            .|||...|..|.|.|:.|::| ..||||::.:||.||::| ....:||:||||..   |.:...|
Zfish  1685 LDSDKLSGGCELTVVIHDFMA-GNSNELTIRRGQTVEVLE-RLHDKPDWCLVRTT---DRSPALE 1744

  Fly  1698 GLVPVSVL--------KPPPG--SHKHGSGTAANAASSAGSQKS-----DMQDQSNRSKADALSS 1747
            ||||.::|        ....|  :||......:|.|...||..:     .|..||        |.
Zfish  1745 GLVPCAMLCIAHSRSSMEMEGIFNHKDALSVCSNDAIMPGSSATLQPGHVMGSQS--------SP 1801

  Fly  1748 STKRRGFSGRNWL--PL-----------------MNRKGTDKPPSSKPLVKKPSEKNLRTPQKHA 1793
            ..||.|.:.|.||  |:                 .::|..|...|:....:|.|:.:..|||   
Zfish  1802 GPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKHKKSRDVRKSADAGSQKDSDDSAATPQ--- 1863

  Fly  1794 EELAEQQNQQPGASPATVLPSSQFPSSTQHPGGAGAGDYEPDEEV-GLELPPPMKPIQEPHLIAN 1857
            :|..|::.:..|.|..|:..||.       .|....|:.|.:|.. .:.||||| .||:..|:..
Zfish  1864 DETLEERVRNEGLSSGTLSKSSS-------SGMQSCGEEEGEEGADAVPLPPPM-AIQQHSLLQP 1920

  Fly  1858 GPPAFAKDAKESSGNMASPGKMD----GNPLSEIEEIVKT--TTEQHESNSRVDGGGGVE---NA 1913
            .    |:|.|.||.....|...:    ...:|.|||:||:  ..|...|...|:.|....   |.
Zfish  1921 D----AQDDKTSSRLSVRPSSSETPSAAELVSAIEELVKSKMALEDRPSTLSVEQGDSSSPSFNP 1981

  Fly  1914 STNGHGRSHDNNDESHTAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDI 1978
            |.|....|....||..   ..|....|||..|..||:.||..||:||..:|.|||..:....   
Zfish  1982 SDNSLLSSSSPIDEIE---ERKTGFFKKRHYVLLELIETERDYVRDLSLVVEGYMARMREDG--- 2040

  Fly  1979 PMPEDLKGGKMKLVFNNIKDIYEWHRDFFLRALRNCQKSPADLGPLIKRSATKFALYYTYCSNKP 2043
             :|:|:| ||.|:||.||:.||:||:||||..|..|.:.|..||||..:...:..:|..||.|||
Zfish  2041 -VPDDMK-GKDKIVFGNIQQIYDWHKDFFLGELEKCLEDPDRLGPLFLKHERRLHMYIVYCQNKP 2103

  Fly  2044 LSEYIVSAHYQ-YFDSIRQKLGHRLDLSNLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQ 2107
            .||:|||.:.. ||:.::|:|||||.:::|:|||||||.||:||:|:.:|.::..|  .:...|:
Zfish  2104 KSEHIVSEYIDTYFEDLKQRLGHRLQITDLLIKPVQRIMKYQLLLKDFLKFSKKIG--TDSIELE 2166

  Fly  2108 EAYQQMKVVVKTVNDMMVVLRSLQDFDGEITAQGSLLMQ----------GPMNCVVDAAQKHREL 2162
            :|.:.|.:|.|..||||.|.| ||.|||:|.|||.||:|          |.:|       :.:|.
Zfish  2167 KAVEVMCIVPKRCNDMMNVGR-LQGFDGKIVAQGRLLLQDTFMVAEPEGGLLN-------RMKER 2223

  Fly  2163 QVFLFQQIIIFADIEKTKNQYASPIFKYRSHIQLNHMQMKELGD---CRFQIRSTDPKIPEMTII 2224
            :||||:||:||::....|..::.|.:.|:..|::|.:.:::..|   |:|.:.|......:...|
Zfish  2224 RVFLFEQIVIFSEPLDKKRGFSMPGYLYKYSIKVNCLGLEDSVDGDPCKFALTSRTSNSSKDAFI 2288

  Fly  2225 CQAASQENYAGWRDMLNKILQQQNDLIFMLSNPL 2258
            ..::.......|...:::||:.|.:.:..|::|:
Zfish  2289 LHSSHPGVRQVWMLQISQILESQRNFLNALTSPI 2322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706 78/138 (57%)
SPEC 314..>468 CDD:238103 82/153 (54%)
SPEC 563..778 CDD:238103 91/218 (42%)
SPEC 782..997 CDD:238103 94/221 (43%)
SPEC 897..1119 CDD:238103 126/231 (55%)
SPEC 1125..1226 CDD:197544 62/100 (62%)
RhoGEF 1287..1455 CDD:459876 101/168 (60%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 70/132 (53%)
SH3_Kalirin_1 1643..1707 CDD:212786 27/71 (38%)
RhoGEF 1945..2121 CDD:459876 77/176 (44%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 39/142 (27%)
trioaXP_021323750.1 SEC14 61..199 CDD:214706 78/139 (56%)
SPEC 212..447 CDD:238103 97/251 (39%)
SPEC 343..589 CDD:238103 111/260 (43%)
SPEC 590..806 CDD:238103 91/219 (42%)
SPEC 810..1037 CDD:238103 98/227 (43%)
SPEC 931..1160 CDD:238103 126/231 (55%)
SPEC 1166..1266 CDD:197544 62/100 (62%)
RhoGEF 1316..1488 CDD:238091 103/171 (60%)
PH1_Kalirin_Trio_like 1495..1627 CDD:270060 70/132 (53%)
SH3_Kalirin_1 1695..1754 CDD:212786 27/63 (43%)
SH3-RhoG_link 1751..2009 CDD:465196 72/283 (25%)
RhoGEF 2007..2180 CDD:238091 78/179 (44%)
PH2_Kalirin_Trio_p63RhoGEF 2185..2324 CDD:270061 41/146 (28%)
PHA03247 <2364..2523 CDD:223021
SH3_Kalirin_2 2570..2628 CDD:212787
I-set 2702..2793 CDD:400151
Ig strand B 2719..2723 CDD:409353
Ig strand C 2732..2744 CDD:409353
Ig strand E 2759..2763 CDD:409353
Ig strand F 2773..2778 CDD:409353
Ig strand G 2786..2789 CDD:409353
Protein Kinases, catalytic domain 2805..3067 CDD:473864
Blue background indicates that the domain is not in the aligned region.

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