DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trio and ARHGEF40

DIOPT Version :9

Sequence 1:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster
Sequence 2:	XP_011535239.1	Gene:	ARHGEF40 / 55701	HGNCID:	25516	Length:	1523	Species:	Homo sapiens

Alignment Length:	1592	Identity:	308/1592 - (19%)
Similarity:	514/1592 - (32%)	Gaps:	531/1592 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   448 PSDIQSLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPP-----PPGVP----- 502
            ||.||.|..|        |.:|..:  ||.....:.:|...|      ||     |||:|
Human   170 PSGIQRLPWA--------ELICPRF--VHKEGLMVGHQPSTL------PPELPSGPPGLPSPPLP 218

  Fly   503 ----------DHRKNSNNGSFNKY---------ERQNPA-ADYSEGASHVLAVIHQI----LSHH 543
                      |.......|...:|         .|.:|. |:.|.|.|.|..|..:.    ...|
Human   219 EEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRH 283

  Fly   544 RTLEAKWHQERLRLHQTLALRLFQEDVKQVLDWLKNHGEVFLRKNTGI-------GRNFHKARVY 601
            |...|..||:.|.              .:..|..:..||   ..:||.       .....:|.|.
Human   284 RRHRAWMHQKGLG--------------PRGQDGARPPGE---GSSTGASPESPPGAEAVPEAAVL 331

  Fly   602 QTSHDNFENVAQNTYS-------------------------------NAQKLLAAA-DELARSGE 634
            :.|....|.|.:.:.|                               |.:|..||. ..|:|.|:
Human   332 EVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGD 396

  Fly   635 ADPNEIYSVARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQE 699
            :.|           |..|                      :|:..:..:.|....|..|.:|.:.
Human   397 SAP-----------LSPG----------------------DKEDASHQEALGNLPSPSEHKLPEC 428

  Fly   700 NLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQEM----------RSLE------YADNTGS 748
            :|     :.::|:...:..|....|.|..:.|..|.|.          |.||      .|.:||.
Human   429 HL-----VKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLLCMAGHTGP 488

  Fly   749 IAALEAT----LEKLNKQKVELEELWSARKFRADLILRLRYFERDARLLSVQMEMWSEELQHADL 809
            ...|..|    ||.:.:.|             .|.|      ..:|..:||.        .|.|:
Human   489 EGPLSDTPTPPLETVQEGK-------------GDNI------PEEALAVSVS--------DHPDV 526

  Fly   810 SRDYQKAEQLIRMHNESVTEIQNATYEVVQQGQDLLQLFENAGFISMADATHTAQARIEYLLDFL 874
            :.|...:..||            .|..|.|.|:.||.:...........:..|....:.||...|
Human   527 AWDLMASGFLI------------LTGGVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLL 579

  Fly   875 REREIDLEEMSEAKRAKLEQA-----------------------------------VQLCQFQ-- 902
            |.   ||:.:..:....|.||                                   .:||.||
Human   580 RP---DLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGA 641

  Fly   903 -----NDANQV-----ISWIRNGEAMLVASFVTPNSLQEAEQ---------------LRKGHEQF 942
                 ||..:|     :.|...|.     ...:|:...|..|               :|:..|:.
Human   642 EVLSENDLKRVAKPEELQWELGGH-----RDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEEL 701

  Fly   943 QIAIEKTHTSAVQV-----KYRADALINANHYD-----------PLSIDEISDDVTKKWQQLVTY 991
            :.|.|.....||.:     |..||..:.|...|           |.|..|.....| .:|::
Human   702 EGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPAT-LYQEV--- 762

  Fly   992 AEERHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCDGGGGSDKAQAIVQLISKHQEQKEAF 1056
            .|..|:||..| |.:...::....|..|::..:    |..|.|               :||..:|
Human   763 DEAIHQLVRLS-NLHVQQQEQRQCLRRLQQVLQ----WLSGPG---------------EEQLASF 807

  Fly  1057 LKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQEN----QVLDYWTLRKKSLD 1117
            ...........||.|::.       .:....:..:....:.|..:||    :|||.:..|.:.::
Human   808 AMPGDTLSALQETELRFR-------AFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQVE 865

  Fly  1118 Q-CQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKL 1181
            . ..:.:..:|..:||.||: :.|.|.|:.    .|..:|.....|........:|...:|...|
Human   866 SGLHRALRLQRFFQQAHEWV-DEGFARLAG----AGPGREAVLAALALRRAPEPSAGTFQEMRAL 925

  Fly  1182 LIQLADSLVEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSL-----------GMSQQQ 1235
            .:.|..         .:.:::|            .|..:.|::||:.:           |..:::
Human   926 ALDLGS---------PAALREW------------GRCQARCQELERRIQQHVGEEASPRGYRRRR 969

  Fly  1236 LLLGSDGNSSISSSSGDRHSDPTLEAKLNSSN--------------------KENKEI------- 1273
                :||.||..:..|.|...|:|.:.|..|:                    :|..|:
Human   970 ----ADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGR 1030

  Fly  1274 ---------------------------------------------NEEKRKSARRKEFIMAELMQ 1293
                                                         ..|:::|...::.:::||:.
Human  1031 PPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIA 1095

  Fly  1294 TERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPED 1358
            .|:.||..|:..:.      ..|..:...|.|.........:.:..||:..|||||:...|.|..
Human  1096 CEQDYVATLSEPVP------PPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLR 1154

  Fly  1359 VGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGGSFFEELQR-RLEVDHPLPAYLIKPVQRITKY 1422
            :|.||:....:|.:|..|.|::..     :::|.:....|.: .:|....||..|.:|::::|:|
Human  1155 IGACFLRHGDQFSLYAQYVKHRHK-----LENGLAALSPLSKGSMEAGPYLPRALQQPLEQLTRY 1214

  Fly  1423 QLLLKDLLSCCEESHGEIKE-------GLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQD 1480
            ..||::||   .|:..|:..       .::::.....:..|.:.:..:..|::.:.:.|:::.:|
Human  1215 GRLLEELL---REAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRD 1276

  Fly  1481 AFQAWDTKQIIRKGRERRVFLFELYLLFAK-EVKESNVVKYQFKSKLMTTDMGITEHIEGDETKF 1544
            .|    |....||...|.|||||..|||:| :..|.....:.:|....|.|||:||:|......|
Human  1277 PF----TVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCF 1337

  Fly  1545 AVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRD 1609
            .:|..|.....  ...|:|||.|.|..|...:.:::..             .|.|       :::
Human  1338 ELWFRRRRARE--AYTLQATSPEIKLKWTSSIAQLLWR-------------QAAH-------NKE 1380

  Fly  1610 LDEQLTENDHDRCSLASFGSGNTTDSDNK-LGNQEATWVVADYIATSGSNELSVSKGQQVEIVEP 1673
            |..|         .:.|.|.||....|.| ||.:..:.::....|.:.:: ::||   ..|...|
Human  1381 LRVQ---------QMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRAS-VAVS---SFEHAGP 1432

  Fly  1674 PTAG-EPDFCLV--RLNPQHDDAAVQEGLVPVSVLKP------------PPGSHKHGS------G 1717
            ...| .|..|.:  |:..:..|..|::    :|:..|            .||.....|      |
Human  1433 SLPGLSPGACSLPARVEEEAWDLDVKQ----ISLASPSAPETLDSSGDVSPGPRNSPSLQPPHPG 1493

  Fly  1718 TAANAASSAGSQKSDMQDQSNRSKADALSSST 1749
            ::....:|.|     :...|.:|.|.|||..|
Human  1494 SSTPTLASRG-----ILGLSRQSHARALSDPT 1520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103	7/19 (37%)
		SPEC	563..778	CDD:238103	45/273 (16%)
		SPEC	782..997	CDD:238103	53/292 (18%)
		SPEC	897..1119	CDD:238103	52/269 (19%)
		SPEC	1125..1226	CDD:197544	18/100 (18%)
		RhoGEF	1287..1456	CDD:279015	40/176 (23%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	36/122 (30%)
		PH	1495..1580	CDD:278594	29/85 (34%)
		SH3_Kalirin_1	1643..1707	CDD:212786	12/66 (18%)
		RhoGEF	1945..2122	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
ARHGEF40	XP_011535239.1	SPEC	786..964	CDD:295325	38/229 (17%)
		RhoGEF	1086..1245	CDD:295373	40/172 (23%)
		PH_puratrophin-1	1244..1379	CDD:270062	39/160 (24%)
		PH	1269..1367	CDD:278594	35/103 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810