DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and arhgef3l

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_005162130.1 Gene:arhgef3l / 553761 ZFINID:ZDB-GENE-050522-85 Length:532 Species:Danio rerio


Alignment Length:519 Identity:116/519 - (22%)
Similarity:199/519 - (38%) Gaps:126/519 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  1156 EETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASV--DQRYKDF--SN 1216
            ||||..|..     |.:..||||:.....|:|...:|.....|...:..|.:  |....||  |:
Zfish     9 EETEVDLSS-----SWSPITRERLLTCANLSDFAGKKRKQDPSSDAENSARILEDCEEDDFPISD 68

  Fly  1217 RM---DSYCEQLEKSL--GMSQQQLL----------LGSDGNSSISSSSGDRHSDPTLEAKLNSS 1266
            .|   :..|.:..|.:  |.|...::          ||.....|||..:..|...|...::..:|
Zfish    69 HMQDSEGPCNKRVKPVDKGASVTGIITPVKTPALKRLGQSIQRSISFRTEARPLPPMPRSRQKAS 133

  Fly  1267 N---KENKEI---------NEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSV 1319
            :   :.:.::         :|...|..:|:| ::.||.|.|:..:.||:...|.:.|.......:
Zfish   134 SFPRRRSSQLWSDTVDNMSHELSTKEIKRQE-VIYELTQGEKQLIEDLSLVKKVYYEPMLKLDIM 197

  Fly  1320 PSALIGQEDVIFGNIKEIHHFHQKIFLR--ELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPT 1382
            ..:.:||   |||.:..:...|:.:.:|  .|...|...::||...:.|....:.|:.||.|:..
Zfish   198 TESELGQ---IFGTLDSLIPLHEDLLVRLEGLRGAEKTVQEVGPTMMDWFPCLEAYITYCCNQVG 259

  Fly  1383 SNNLLVQ--------------HGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCC 1433
            :..||.|              ...||    .|:|:    |..:|..|..|:.||.||||::....
Zfish   260 AKALLDQKKQDKRVEQFLRLCQESSF----SRKLD----LWNFLDLPRSRLVKYPLLLKEIQKST 316

  Fly  1434 EESHGE---IKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQ----DAFQAWDTKQII 1491
            ...|.:   :.:.:|::..:..:.|               .|.||...|    ....|.|::::.
Zfish   317 PLDHPDEDALPQAMELIQRIITEVN---------------LKTGEAECQFYRRGLCYAEDSQRVA 366

  Fly  1492 R----------------KGRERRVFLFELYLLFAKEVKE--SNVVKYQ-FKSKLMTTDMGITEHI 1537
            .                ||::..||||||.|:..:.|.:  ...|::| ::..:....:.:.:..
Zfish   367 EIQASRFLYCHGELKSTKGQKLHVFLFELVLVLTRPVAQDREGPVQFQVYRQPMPAAHLHLEDLP 431

  Fly  1538 EG---------------DETK--FAV-WTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQET 1583
            :|               |:.|  |.| .||||...|..   |:|.....||.|:..||:.|.::
Zfish   432 DGEPSSSGSFRGAFTGNDKVKNCFRVSTTGRSKSQSHS---LQANDSFNKQQWISCLRQAMVQS 492

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544 21/76 (28%)
RhoGEF 1287..1456 CDD:279015 43/187 (23%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 36/163 (22%)
PH 1495..1580 CDD:278594 27/105 (26%)
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
arhgef3lXP_005162130.1 RhoGEF 165..341 CDD:279015 43/186 (23%)
PH_RhoGEF3_XPLN 355..489 CDD:269976 31/136 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3601
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.940

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