Protein Alignment trio and arhgef7a

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_021334338.1
• Gene: arhgef7a / 553493
• ZFINID: ZDB-GENE-060322-11
• Length: 864
• Species: Danio rerio
• Alignment Length: 933
• Identity: 179/933 - (19%)
• Similarity: 313/933 - (33%)
• Gaps: 249/933 - (26%)

  Fly   982 TKKWQQLVTYAEERHKLVTASINF----YKTAEQVCSVLDSLEREYKREDDWCDGGGGSDKAQAI 1042
            |..|...:...|...|.::....|    .|....:|.:|:.|.            .|.:||
Zfish     7 TVTWLITLGVLESPKKTISDPDGFLQASLKDGVVLCRLLERLR------------PGTTDK---- 55

  Fly  1043 VQLISKHQEQKEA------FLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQ 1101
              :|...:...|.      |||.|.:.|  .|.|           :.....:||..|::...|..
Zfish    56 --IIQDPKNDSECLSNITEFLKGCAVFR--VEPF-----------EAGDLLQGHNISRVLTTLVA 105

  Fly  1102 ENQVL-------DYWTLRKKSLDQCQQF--VLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEE 1157
            .|:|.       |....|..|..:.:.|  :..:.|..::.:.:||...:.:|:..::...|..:
Zfish   106 LNKVTADIGIGSDSVCTRHSSAHRIKSFESLASQSSLGRSSKLLHNQFRSLVSNIGDMTDNSNAQ 170

  Fly  1158 TEGLLKEHNEFRSTAKETRERVKLLIQLADSL----VEKGHAHASDIKQWVASVDQRYKDFSNRM 1218
            .  ::|....|:.|.::     :|.....|.:    .|:|       ..|...::.:...|.:
Zfish   171 L--VVKARFNFQQTNED-----ELTFSKGDLISVTRTEEG-------GWWEGILNGKTGWFPS-- 219

  Fly  1219 DSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNSSNKENKEINEEKRKSARR 1283
             :|.::::            |||  ..:|..||:..|.|        ...:...|      |...
Zfish   220 -NYVKEVK------------GSD--KQVSPKSGNLKSPP--------KGFDTASI------SKTY 255

  Fly  1284 KEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIF--L 1346
            ...::..:::||..|..:|...:..:|...:..:.:..|.:   .||.||::||..|.|.:.  |
Zfish   256 YNLVLQNILETETEYSRELQNLLTSYLRPLQMTERLSPADV---SVILGNLEEISTFQQTLVQSL 317

  Fly  1347 RELEKYETMPEDVGHCFVTWASKF-DMYVHYCKNKPTSNNLLVQHG---GSFFEELQRRLEVDHP 1407
            .:|.|...:.:.||..|:....:. .:.|.||.|.|::.|:|..|.   |.|.|.....:.....
Zfish   318 EDLTKLPELQQKVGGFFLNLMPQMRSLNVSYCSNHPSTVNVLTVHSEELGEFMEARGASVPGILT 382

  Fly  1408 LPAYLIKPVQRITKYQLLLKDLLSCCEESH---GEIKEGLEVMLNVPKKAND------------A 1457
            |.:.|.||..|:.:|..|||:|....||.|   .||::.:....|:..:..:            |
Zfish   383 LTSGLSKPFMRLDRYPTLLKELERHMEEGHPDRTEIQKCMTAFKNLSAQCQEVRKRKELELQILA 447

  Fly  1458 MHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLF-ELYLLFAKEVKESNVVKYQ 1521
            ..:.|.|..|:..  ||.|:...  ||........:..||.:.|| .:.|:.:...:.|..:
Zfish   448 ETIRLWEGEDIKT--LGSVLYMS--QAMVQNHGCEEKNERYLLLFPHVLLILSASPRMSGFI--- 505

  Fly  1522 FKSKLMTTDMGITEHIEGDETKFAVWTGRSPMLSDCR-----IVLKATSLETKQI---------- 1571
            ::.||..:.|.:|.                  |.||.     ..|..:..|..|:
Zfish   506 YQGKLPLSGMTVTP------------------LEDCESHKDAFELSGSMFERLQVICYNKQDLHD 552

  Fly  1572 WVKKLREVMQETCFSGTSL--------TLPKSPAKHSGSSQRSSRDLDEQLTENDHDRCSLASFG 1628
            |::.|....:.|..:..|:        |||..|                 ||.:.|
Zfish   553 WLEHLNRQTKHTTMAAPSMKPLTVPCHTLPSHP-----------------LTPSRH--------- 591

  Fly  1629 SGNTTDSDNKLGNQEATWVVADY-----IATSGSNELSVSKGQQVEIVEPPTAGEP--DFCLVRL 1686
                       |......|...|     .::.|:...::..|.    :|||...:|  ..||...
Zfish   592 -----------GESRGLTVAPAYHTLPHPSSHGTPHSTMMWGP----LEPPKTQKPWSLSCLRPA 641

  Fly  1687 NPQHDDAAV--QEGL--VPVSVLKPPP---GSHKHGSGTAANAASSAGSQKSDMQDQSNRSKADA 1744
            .|....||:  :|.|  .|.::.|..|   ...|......|...|:...:    :|.......:|
Zfish   642 PPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFALRKSTVALE----EDAQILKVIEA 702

  Fly  1745 LSSSTKRRGFSGRNW--LPLMN--------------RKGTDKPPSSKPLVKKPSEKNLRTPQKHA 1793
            ..:|.|.|......|  ..||:              |....:|.::..|.:.....::.|  .|:
Zfish   703 YCTSAKTRQTLNSTWQGTDLMHNHVLDQSSADSLGRRSSISRPEATSDLSEDSDYDSIWT--AHS 765

  Fly  1794 EELAEQQNQQPGASPATVLPSSQ 1816
            ..:.....|....|||.::|..:
Zfish   766 YRMGSVTRQWKDGSPALIVPGDE 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103	3/14 (21%)
		SPEC	897..1119	CDD:238103	30/153 (20%)
		SPEC	1125..1226	CDD:197544	15/104 (14%)
		RhoGEF	1287..1455	CDD:459876	47/176 (27%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	26/137 (19%)
		SH3_Kalirin_1	1643..1707	CDD:212786	16/74 (22%)
		RhoGEF	1945..2121	CDD:459876
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
arhgef7a	XP_021334338.1	CH_SF	4..114	CDD:469584	27/137 (20%)
		RhoGEF67_u1	116..168	CDD:465201	8/51 (16%)
		SH3_alphaPIX	170..226	CDD:212993	10/72 (14%)
		RhoGEF	256..433	CDD:238091	47/179 (26%)
		PH_Cool_Pix	464..562	CDD:269932	21/120 (18%)
		RhoGEF67_u2	621..711	CDD:465200	22/97 (23%)
		betaPIX_CC	779..863	CDD:465158	4/10 (40%)