DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and Ccdc141

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_001020747.2 Gene:Ccdc141 / 545428 MGIID:1919735 Length:1531 Species:Mus musculus


Alignment Length:1871 Identity:340/1871 - (18%)
Similarity:592/1871 - (31%) Gaps:642/1871 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   266 QQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQW---RLFEQDCEKMFD 327
            ::|..||.:....::|        .:|.|..|::       :.:.:|.:|   :|.|.       
Mouse     4 KESPHVGASTTTVSSV--------AVHAGDSKIV-------IAVVKCGKWVRLQLAES------- 46

  Fly   328 WILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVAARLIESQHYAAQHI 392
                     |.:.:|||.:....|.|..:|:........:...:..:|..|.|..|:....:|..
Mouse    47 ---------QPNLLEIGSSQDETKKLLHDHELLLAKLKALEDRVWELLREADRTAEANKAQSQVY 102

  Fly   393 KTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQPLPSDIQSLETA 457
            ..:||.|...|....:.|:.|..:|.|:..|...|                          ||.|
Mouse   103 DAMAQTLGEAWATLVSMLERRRELLGLTSEFFQSA--------------------------LEFA 141

  Fly   458 IRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHRKNSNNGSFNKYERQNPA 522
            |:..|:  ||..|...|..||.                                           
Mouse   142 IKIDQA--EAFLQNPHEFESTE------------------------------------------- 161

  Fly   523 ADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQEDVKQVLDWLKNHGEVFLRK 587
                       |:...:|.|.|      |.:.|              :::.||.|          
Mouse   162 -----------ALQSLLLLHDR------HAKEL--------------LERSLDLL---------- 185

  Fly   588 NTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGEADPNEIYSVARELELQVG 652
                                         :.:|:|....::....|....:|:...|:...|::.
Mouse   186 -----------------------------NKSQQLTDFIEKFKCEGSTMNSELIQGAQSSCLKID 221

  Fly   653 SFAERVEQRRRRLD--------------MAVIFYTHEKDVTAWIDKLRTDVSTDETRLS-QENLE 702
            |..|.::.|||:||              ...::...|..|::|..|...|:.......| .:|.|
Mouse   222 SLLELLQDRRRQLDKYLQQQRQELSQVLQLCLWDQQENQVSSWFQKAIRDLQEQSLGASLSDNRE 286

  Fly   703 GIERILQQYQRDQQESSVNVCLTTISQGEALLQEMRSLEYADNTGSIAALEATLEKLNKQKVELE 767
            .|.:......:.::..|....|.:.:.|..|.:::...|:         |:.:.:|||:.:.|..
Mouse   287 LICKHEDLIVKAKEWDSAVEKLKSQALGILLSKDLAGKEH---------LQLSNQKLNRLQEEFG 342

  Fly   768 ELWSARKFRADLILRLRYFERDARLLSV--QMEMWSEELQHADLSRDYQKAEQLIRMHNESVTEI 830
            .|...||  |.|.:...:|....:...|  ::|.:.:.|:...||.....|:     |.|...||
Mouse   343 RLMVERK--AWLSMANDFFTSANKSFDVLGKVEAYLKLLKSEGLSLPVLAAK-----HEELHREI 400

  Fly   831 QNATYEVVQQGQDLLQLFENAGFISMADATHTAQARIEYLLDFLREREIDLEEM----SEAKRAK 891
            :::|...:|:|:.|         ||..|:..:....|..::.:::.|...|.|.    .|..|.:
Mouse   401 KDSTATALQKGRTL---------ISQVDSCRSRVTGIHEMMGYIQNRVDCLTEQCTAHEEFARKR 456

  Fly   892 LEQAVQLCQFQNDANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIEKT-HTSAVQ 955
            .:.|..:..:.......|..||   .:|..:....:|..|:|::...:.:..|.:::| |.....
Mouse   457 QQLATSVDDYLRKVEMSIQEIR---PILATTLDVASSPSESEKILNKYLELDIQVKETAHALEAA 518

  Fly   956 VKYRADALINANHYDPLSIDEISDDVTK-KW--QQLVTYAEE---RHKLVTASINFYKTAEQVCS 1014
            .|...:.       :.|.::|::....| ||  ::|.|....   |.:::...:.|.|::|:...
Mouse   519 AKIMTEK-------NELELNEVALLPLKVKWLEEELSTLGRSISCRSRILQTYVAFRKSSEEAEE 576

  Fly  1015 VLDSLEREYKREDDWCDGGGGSDKAQAIVQLISKHQEQK-EAFLKACTLARRTAETFLKYANRSQ 1078
            .|.||:..|..|..|      .|:..|:|:..|...|:| :.|||...|.:..:..||...|   
Mouse   577 QLQSLKEFYLTEIPW------KDEDDAVVKCQSNSAERKWQLFLKKSFLTQDLSLEFLNLIN--- 632

  Fly  1079 QCYQYKGNCEGHVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAY 1143
                                :.:||::|                     :.|..:..:.|..|..
Mouse   633 --------------------MAKENEIL---------------------NVKNEMHIMENIMEKQ 656

  Fly  1144 LSSRSNL----VGISKEETEG--LLKEHNEFRSTAKETRERVKLL--IQLADSLVEKGHA--HAS 1198
            .:.|..|    |....:..||  ..::...|:....:|...||||  :.:..|.::.|.:  ..|
Mouse   657 TNGREELSHLRVAWYLKAIEGKPAREQWEMFKEKLTKTTHSVKLLHEVLMPVSALDLGGSLQSTS 721

  Fly  1199 DI-KQWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQL-----LLGSDGNSSISSSSGDRHSDP 1257
            |: ::|:|            |....:||.:.:    ||:     :|.|.|               
Mouse   722 DLRRRWIA------------MKPQLQQLHEDV----QQITKEWEVLSSQG--------------- 755

  Fly  1258 TLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSA 1322
               |.|             |.|:.:.|:.:.....|.||             ::|:         
Mouse   756 ---APL-------------KEKAEQLKDLVHLHRRQRER-------------IQEY--------- 782

  Fly  1323 LIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLL 1387
                |::::..::    |||            :.|::.|..                ||....||
Mouse   783 ----EEILYKTVQ----FHQ------------VKEELVHLI----------------KPRELELL 811

  Fly  1388 VQH---GGSFFEELQ--------RRLEVDH------PLPAYLIKPVQRITKYQLLLKDL------ 1429
            .|.   ..|  ||:|        ||..|||      .|...:|..||:.....:..|:|      
Mouse   812 AQPMELASS--EEVQMQLGRSQERRAHVDHLHQLALTLGVDIISSVQQPNCSNISAKNLQQQLEA 874

  Fly  1430 ------------------LSCCEE---SHGEIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKL 1473
                              |||..|   :..||.|..|...::.||.|         |...:..|.
Mouse   875 LELESRSWSAQAKEHERVLSCSLEYCTARDEISELKESFKDIKKKFN---------NLKFNYSKK 930

  Fly  1474 GE-----VVLQDAFQAWDTK----QIIRKGRE----------------RRVFLFELYLLFAKEVK 1513
            .|     ..||...|..||.    |.:||..|                :...|.|......|.|.
Mouse   931 NEKSRNLKTLQYQIQQVDTYAEKIQALRKKMEKVNNKTSDSFLSYPSNKANMLSEAMEDLKKNVD 995

  Fly  1514 ESNVVKYQFKSKLMTTDMGITEHIE----------GDETKFAVWTGRSPMLSDCR---------- 1558
            :.:.|...:|..|     .:|||::          .|.:...|..|:..|  :|:          
Mouse   996 DFDKVVTDYKMNL-----DLTEHLQEVIEECNFWYEDASATVVRVGKYSM--ECQTREAVDILHR 1053

  Fly  1559 ----------------------IVLKATSLETKQIWVKKL----REVMQ---ETCFSGTSLTLPK 1594
                                  :..:...||..|.:.:|:    :|:::   |.|  |:.:.|.:
Mouse  1054 QFNKFITPSVPQQEERIQEVIDLAQRLYGLEEGQKYAEKIVTRHKEILESITELC--GSLVELKE 1116

  Fly  1595 SPAKHSGSSQRSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYIATSGSNE 1659
            ...:  |...:.:.||     |:.||.|.....|.|............|.....||.:|.:|:.|
Mouse  1117 KLMQ--GEVPKMNSDL-----EDFHDNCIDLLKGPGKDDQKTFSEERNEGQVQGADVLAVNGTRE 1174

  Fly  1660 LSV------------SKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSH 1712
            ..:            ...|.:.:.|...:||...|:     ..||.::..  :|||...|     
Mouse  1175 DGLPMDLRRTSSDKEDSAQGLILPEDTLSGEESECI-----SSDDISLPP--LPVSPESP----- 1227

  Fly  1713 KHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWLPLMNRKGTDKPPSSKPL 1777
                           ...|||:.:      :..|||......||....|     ||..       
Mouse  1228 ---------------LAPSDMEVE------ELTSSSALALHISGYRMHP-----GTGG------- 1259

  Fly  1778 VKKPSEKNLRTPQKHAE------ELAEQQNQQPGASPATVLPSSQFPSSTQHPGGAGAGDYEPDE 1836
            :.|..|..|.:|...|:      :......::|       .|..:..||....|.|         
Mouse  1260 LGKAQESALPSPIAFADGGHSKKDTFTSHFERP-------YPQLKAESSLASRGSA--------- 1308

  Fly  1837 EVGLELPPPMK-PIQEPHLIANGPPAFAKDAKESSGNMASPGKMDGNPLSEIEEIVKTTTEQHES 1900
            |:..:|...:| |...||.:.:........|:||:..|......|.|       :.||....|.:
Mouse  1309 EMSTKLHINVKCPASMPHEVHDKALQQCSQARESTLEMQEKVHADSN-------VTKTQDRLHAA 1366

  Fly  1901 NSRVDGGGGVENASTNGHGRSHDNNDESHTAVSDKAAALKKRQCVFAELMS 1951
            .....|.|...:.|.:...|.....::.:::..:...:|..:...|:.|:|
Mouse  1367 LDVSPGLGSQPDTSESHQRRVGPQGNKKNSSAENSVVSLAGQAPHFSRLLS 1417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103 31/156 (20%)
SPEC 563..778 CDD:238103 38/229 (17%)
SPEC 782..997 CDD:238103 44/227 (19%)
SPEC 897..1119 CDD:238103 44/229 (19%)
SPEC 1125..1226 CDD:197544 22/111 (20%)
RhoGEF 1287..1456 CDD:279015 40/212 (19%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 33/195 (17%)
PH 1495..1580 CDD:278594 21/146 (14%)
SH3_Kalirin_1 1643..1707 CDD:212786 16/75 (21%)
RhoGEF 1945..2122 CDD:279015 3/7 (43%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
Ccdc141NP_001020747.2 SPEC 132..356 CDD:238103 59/375 (16%)
sbcc <219..790 CDD:129705 138/728 (19%)
SMC_prok_A <712..999 CDD:274009 75/402 (19%)
I-set 1410..1499 CDD:369462 3/8 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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