DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and Arhgef7

DIOPT Version :10

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_036010059.1 Gene:Arhgef7 / 54126 MGIID:1860493 Length:919 Species:Mus musculus


Alignment Length:1124 Identity:221/1124 - (19%)
Similarity:388/1124 - (34%) Gaps:343/1124 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   978 SDDVTKKWQQLVTYAEERHKLVT-------ASINFYKTAEQVCSVLD-----SLEREY--KREDD 1028
            |.:.|..|...:...|...|.::       ||:   |....:|.:|:     ::|:.|  .|.:.
Mouse     3 SAEQTVTWLITLGVLESPKKTISDPEVFLQASL---KDGVVLCRLLERLLPGTIEKVYPEPRNES 64

  Fly  1029 WCDGGGGSDKAQAIVQLISKHQEQKEAFLKAC-------TLARRTAETFLKYANRSQQCYQYKGN 1086
            .|               :|..:|    ||:||       .|..||:.:|..|...:|       |
Mouse    65 EC---------------LSNIRE----FLRACGASLRLEKLDTRTSVSFHLYLKTNQ-------N 103

  Fly  1087 CE--GHVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNT---------- 1139
            |:  |.|.|                   ..:||.|.|..|.:|.....:..:...          
Mouse   104 CDGGGAVGS-------------------GDALDVCNQKYLSDRETSHGVLCLSAAPQTFDANDLY 149

  Fly  1140 -GEAYLSSRSNLVGISKEETE-GLLKEHNEFRSTAKETRERVKLLIQLADSL-VEKGHAHASDIK 1201
             |:.:....|:||.::|...: ||..:    ...|:.:..|:|..    ||| .:..|:..|.:.
Mouse   150 QGQNFNKVLSSLVTLNKVTADIGLGSD----SVCARPSSHRIKSF----DSLGSQSSHSRTSKLL 206

  Fly  1202 QWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGD-------------- 1252
            |      .:|:.. :..|:...||......:.||     .....:|.|.||              
Mouse   207 Q------SQYRSL-DMTDNTNSQLVVRAKFNFQQ-----TNEDELSFSKGDVIHVTRVEEGGWWE 259

  Fly  1253 ------------------RHSDPTLEAKLNSSNKENKEINEEKRKSARRKEF---IMAELMQTER 1296
                              :.|:..:..|..:.....|..:    .:|..|.:   ::..:::||.
Mouse   260 GTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFD----TTAINKSYYNVVLQNILETEH 320

  Fly  1297 AYVNDLATCIKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPE---D 1358
            .|..:|.:.:..:|...:....:.||   ....:.||::||..| |::.::.||:....||   .
Mouse   321 EYSKELQSVLSTYLRPLQTSDKLSSA---NTSYLMGNLEEISSF-QQVLVQSLEECTKSPEAQQR 381

  Fly  1359 VGHCFVTWASKF-DMYVHYCKNKPTSNNLLVQHG---GSFFEELQRRLEVDHPLPAYLIKPVQRI 1419
            ||.||::...:. .:|:.||.|.|::.::|.:|.   |.|.|...........|...|.||..|:
Mouse   382 VGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRL 446

  Fly  1420 TKYQLLLKDLLSCCEESH---GEIKEGLEVMLNVPKKANDA-----MHLSLL-------ENCDV- 1468
            .||..|||:|....|:.|   .:|::.:....|:..:..:.     :.|.:|       |..|: 
Mouse   447 DKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIK 511

  Fly  1469 ---SVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLF-ELYLLFAKEVKESNVVKYQFKSKLMTT 1529
               ||..:.:|.:|.|..        .:..||.:.|| .|.|:.:...:.|..:   ::.||.||
Mouse   512 TLGSVTYMSQVTIQCAGS--------EEKNERYLLLFPNLLLMLSASPRMSGFI---YQGKLPTT 565

  Fly  1530 DMGITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETCFSGTSL---- 1590
            .|.||: :|..|.....:.....|:.  ||::..||.:....||:.|::..:.|..|..::    
Mouse   566 GMTITK-LEDSENHRNAFEISGSMIE--RILVSCTSQQDLHEWVEHLQKQTKVTSVSNPTIKPHS 627

  Fly  1591 ----TLPKSP----AKHSGSSQRSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWV 1647
                |||..|    :||:.|...:       ||...|.....:..|:.:||              
Mouse   628 VPSHTLPSHPLTPSSKHADSKPVA-------LTPAYHTLPHPSHHGTPHTT-------------- 671

  Fly  1648 VADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSH 1712
                          :|.|.    :|||...:|                    ..:|.|:|.|...
Mouse   672 --------------ISWGP----LEPPKTPKP--------------------WSLSCLRPAPPLR 698

  Fly  1713 KHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWLPLMNRKGTDKP--PSSK 1775
                      .|:|...|.|            ||.|.|                 |.|.  |..|
Mouse   699 ----------PSAALCYKED------------LSKSPK-----------------TMKKLLPKRK 724

  Fly  1776 PLVKKPSEKNLRTPQKHAEELAEQQNQQPGASPATVLPSSQFPSSTQHPGGAGAGDYEPDEEVGL 1840
            | .:|||::.....:..|....:.|..:...:..|...:.|..:||..               |.
Mouse   725 P-ERKPSDEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQ---------------GT 773

  Fly  1841 ELPPPMKPIQEPHLIANGPPAFAKDAKESSGNMASPGKMDGNPLSEIEEIVKTTTEQ-----HES 1900
            :|       ...|::|:..    :.:.:|.|..:|..:::.:.|||..|.....|..     ..|
Mouse   774 DL-------MHNHVLADDD----QSSLDSLGRRSSLSRLEPSDLSEDSEYDSIWTAHSYRMGSAS 827

  Fly  1901 NSRVDGGGG----------VENASTNGHGRSHDNN-DESHTAVSDKAAALKKRQCVFAELMSTEE 1954
            .||.:....          ||...:||.....:.: .::..|:.|:...|::......:.:..|:
Mouse   828 RSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQ 892

  Fly  1955 AYVQDLHEIVNGYMTEINN 1973
            ...:||.::|...:..:|:
Mouse   893 RARKDLEKLVRKVLKNMND 911

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103 4/18 (22%)
SPEC 897..1119 CDD:238103 33/163 (20%)
SPEC 1125..1226 CDD:197544 20/113 (18%)
RhoGEF 1287..1455 CDD:459876 46/177 (26%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 32/133 (24%)
SH3_Kalirin_1 1643..1707 CDD:212786 8/63 (13%)
RhoGEF 1945..2121 CDD:459876 5/29 (17%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
Arhgef7XP_036010059.1 CH_SF 3..172 CDD:469584 42/216 (19%)
RhoGEF67_u1 174..220 CDD:465201 11/60 (18%)
SH3_betaPIX 224..277 CDD:212994 6/57 (11%)
RhoGEF 308..485 CDD:238091 46/180 (26%)
PH_Cool_Pix 516..614 CDD:269932 28/111 (25%)
RhoGEF67_u2 673..764 CDD:465200 29/154 (19%)
betaPIX_CC 834..918 CDD:465158 12/78 (15%)
Blue background indicates that the domain is not in the aligned region.

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