| Sequence 1: | NP_651960.2 | Gene: | trio / 43974 | FlyBaseID: | FBgn0024277 | Length: | 2263 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001104784.1 | Gene: | Ngef / 53972 | MGIID: | 1858414 | Length: | 710 | Species: | Mus musculus |
| Alignment Length: | 675 | Identity: | 130/675 - (19%) |
|---|---|---|---|
| Similarity: | 244/675 - (36%) | Gaps: | 230/675 - (34%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 1729 QKSDMQDQSNRSKADALSSSTKRRGFSGRNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKH- 1792
Fly 1793 --AEELAEQQNQQPG------------ASPATV---------LPSSQFPSSTQHPG--------- 1825
Fly 1826 -------------------------GAGAGDYEPDEEVG----LELPPPMKPIQEPHLIANGPPA 1861
Fly 1862 FA--KDAKESSGNMASPGKMDGNPLSEIEEIVKTTTEQHESNSRVDGGGGVENASTNGHGRSHDN 1924
Fly 1925 NDESHTAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKM 1989
Fly 1990 KLVFNNIKDIYEWHRDFFLRALRNCQKS--PADLGPLIKR-SATKFALYYTYCSNKPLSEYIVSA 2051
Fly 2052 HYQYFDSIRQKLGHR--------------LDLSNLIIKPVQRITKYELLIKEIIKAT------EG 2096
Fly 2097 AGLYKEVPMLQEAYQQMKVVVKTVN---------DMMVVLRSLQDFDGE----------ITAQGS 2142
Fly 2143 L-LMQGPMNCVVDAAQK-HRELQVFLFQQIIIFA-DIEKTKNQYASPIFKYRSHIQLNHMQMKEL 2204
Fly 2205 GDCRFQI------RSTDPKIPEMTIICQAASQENYAGWRDML--NK------------------- 2242
Fly 2243 ----ILQQQNDLIFMLSNPLSTKNK 2263 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| trio | NP_651960.2 | SEC14 | 13..152 | CDD:214706 | |
| SPEC | 314..>468 | CDD:238103 | |||
| SPEC | 563..778 | CDD:238103 | |||
| SPEC | 782..997 | CDD:238103 | |||
| SPEC | 897..1119 | CDD:238103 | |||
| SPEC | 1125..1226 | CDD:197544 | |||
| RhoGEF | 1287..1456 | CDD:279015 | |||
| PH1_Kalirin_Trio_like | 1462..1584 | CDD:270060 | |||
| PH | 1495..1580 | CDD:278594 | |||
| SH3_Kalirin_1 | 1643..1707 | CDD:212786 | |||
| RhoGEF | 1945..2122 | CDD:279015 | 49/208 (24%) | ||
| PH2_Kalirin_Trio_p63RhoGEF | 2130..2260 | CDD:270061 | 33/173 (19%) | ||
| Ngef | NP_001104784.1 | Regulatory region, modulates activity toward RHOA, RAC1 and CDC42 | 1..272 | 44/224 (20%) | |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..146 | 20/91 (22%) | |||
| ELH | 3..>156 | CDD:145463 | 23/101 (23%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 192..234 | 10/41 (24%) | |||
| RhoGEF | 277..456 | CDD:279015 | 48/200 (24%) | ||
| PH_ephexin | 477..603 | CDD:269929 | 27/131 (21%) | ||
| PH | 490..596 | CDD:278594 | 25/111 (23%) | ||
| SH3_ephexin1 | 616..670 | CDD:212872 | 6/29 (21%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 688..710 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3601 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 1.030 | |||||