DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and Arhgef25

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_082303.2 Gene:Arhgef25 / 52666 MGIID:1277173 Length:618 Species:Mus musculus


Alignment Length:531 Identity:164/531 - (30%)
Similarity:256/531 - (48%) Gaps:71/531 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly  1767 GTDKPPSSKPL----VKKPSE--KNLRTPQKHAEELAEQQNQQP------------GASPATVLP 1813
            |.:.||...||    .|..|:  :..:|.|:..|.||  ...||            .||..:.|.
Mouse    30 GQEGPPERDPLGPGSTKTESDCIEEDQTGQREPEVLA--WAPQPESYSIAVSEGSMSASAVSGLA 92

  Fly  1814 SSQFPSSTQHPGGAGAGDYEPDEEVGLELPP-PMKPIQEPHLIANGPPAFAKDAKESSGNMASPG 1877
            :...|||     |..:....|       :|| |:..::  ..:.:.....:.:.:..||......
Mouse    93 ALSGPSS-----GLSSDPCSP-------IPPGPVTGLR--RWLDHSKHCLSVETEAESGQTGQCE 143

  Fly  1878 KMDGNPL----SEIEEIVKTTTEQHESNSRVDG-GGGVENASTNGHGRSHDNNDESHTAVSDKAA 1937
            .....|.    .|:.|:...||       .::| |...:.|......::..|.:|      .|..
Mouse   144 NWTLEPTLTTGQELPELTLLTT-------LLEGPGDKAQPAEEETLSQAPKNEEE------QKKM 195

  Fly  1938 ALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEW 2002
            ||::...|..||:.||..||.||.:||.|||.    |.:...:||.|: |:.::||.||:.||||
Mouse   196 ALERSMFVLGELVETERTYVDDLGQIVEGYMA----TMATQGVPESLR-GRDRIVFGNIQQIYEW 255

  Fly  2003 HRDFFLRALRNCQKSPADLGPLIKRSATKFALYYTYCSNKPLSEYIVSAH-YQYFDSIRQKLGHR 2066
            |||:||:.|:.|.|.|..|..|..:...:..:|..||.|||.||:::|.. ..||:.:||:||||
Mouse   256 HRDYFLQELQQCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVLSEFGDSYFEELRQQLGHR 320

  Fly  2067 LDLSNLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVNDMMVVLRSLQ 2131
            |.|::|:|||||||.||:||:|:.:|....||  |:...|::|.:.|..|.|..||||.:.| |:
Mouse   321 LQLNDLLIKPVQRIMKYQLLLKDFLKYYRRAG--KDTEELEQAVEVMCFVPKRCNDMMSLGR-LR 382

  Fly  2132 DFDGEITAQGSLLMQGPMNCVVDAA-----QKHRELQVFLFQQIIIFAD-IEKTKNQYASPIFKY 2190
            .|:|::||||.||.|.........|     .:.||.:||||:|||||:: :.......|.|.:.|
Mouse   383 GFEGKLTAQGKLLGQDTFLVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGGRGGAQPGYVY 447

  Fly  2191 RSHIQLNHMQMK---ELGDCRFQIRSTDPKIPEMTIICQAASQENYAGWRDMLNKILQQQNDLIF 2252
            ::.|:::.:.::   :...|||.:.|..|:......:.||:.......|...:.:||:.|.|.:.
Mouse   448 KNSIKVSCLGLEGNLQGNPCRFALTSRGPEGGIQRYVLQASDPAVSQAWIKQVAQILESQRDFLN 512

  Fly  2253 MLSNPLSTKNK 2263
            .|.:|:..:.:
Mouse   513 ALQSPIEYQRR 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1456 CDD:279015
PH1_Kalirin_Trio_like 1462..1584 CDD:270060
PH 1495..1580 CDD:278594
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2122 CDD:279015 79/177 (45%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 40/138 (29%)
Arhgef25NP_082303.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..63 9/32 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..193 5/29 (17%)
RhoGEF 203..374 CDD:279015 79/177 (45%)
Important for binding to Rho GTPases. /evidence=ECO:0000250 317..338 15/20 (75%)
PH2_Kalirin_Trio_p63RhoGEF 378..520 CDD:270061 41/142 (29%)
Sufficient to bind activated GNAQ. /evidence=ECO:0000250 506..532 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..556 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 584..604
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 148 1.000 Domainoid score I4441
eggNOG 1 0.900 - - E1_KOG0689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.770

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