Protein Alignment trio and ARHGEF3

DIOPT Version :9

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_001122087.1
• Gene: ARHGEF3 / 50650
• HGNCID: 683
• Length: 558
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 102/539 - (18%)
• Similarity: 190/539 - (35%)
• Gaps: 166/539 - (30%)

  Fly  1716 SGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWLPLMNRKGTDKPPSSKPL--- 1777
            |.||.|..|..|.:::..:.:..|.....:..|.|...|.||      .||.:.:...:..|
Human     3 SSTAMNQCSCRGMEENKERPKRQRQNNFPMFPSPKAWNFRGR------KRKQSTQDEDAVSLCSL 61

  Fly  1778 -VKKPSEKNLRTPQKHAEELAEQQNQQPGASPATVLPSSQFPSSTQHPGGAGAGDYEPDEEVGLE 1841
             :.:||.|.:: |......||   |..|   |....|..:|..:                   |:
Human    62 DISEPSNKRVK-PLSRVTSLA---NLIP---PVKATPLKRFSQT-------------------LQ 100

  Fly  1842 LPPPMKPIQEPHLIANGPPAFAKDAKESSGNMASPGKMDGNPLSEIEEI----VKTTTEQHESNS 1902
            .....:....|.::|  |..::::|..||..     :.|....||..::    :.|:.|
Human   101 RSISFRSESRPDILA--PRPWSRNAAPSSTK-----RRDSKLWSETFDVCVNQMLTSKE------ 152

  Fly  1903 RVDGGGGVENASTNGHGRSHDNNDESHTAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGY 1967
                                                :|:::.:| ||...||..::||......|
Human   153 ------------------------------------IKRQEAIF-ELSQGEEDLIEDLKLAKKAY 180

  Fly  1968 ---------MTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFF--LRALRNCQKSPADL 2021
                     |||                .::..:|..:..:...|.:..  ||.:|....|...:
Human   181 HDPMLKLSIMTE----------------QELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHV 229

  Fly  2022 GPLIKRSATKFALYYTYCSNKPLSEYIV---SAHYQYFDSIRQKL----GHRLDLSNLIIKPVQR 2079
            ||::.......:.|.:||||:..::.::   ...::..|.:::.|    ..:|||.|.:..|..|
Human   230 GPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSR 294

  Fly  2080 ITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVNDMMVVLRSLQDFDGEITAQGS-- 2142
            :.||.||::||::.|....  .:...|:||...::.:|..:|                |..|.
Human   295 LVKYPLLLREILRHTPNDN--PDQQHLEEAINIIQGIVAEIN----------------TKTGESE 341

  Fly  2143 ---------LLMQGPMNCVVDAAQK---HRELQ--------VFLFQQIIIFADIEKTKNQYASPI 2187
                     .|.:|..:.::|:::.   |.||:        |||||::::.........|....:
Human   342 CRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQL 406

  Fly  2188 FKYRSHIQLNHMQMKELGD 2206
              ||..|.:..:.:::|.|
Human   407 --YRQPIPVKDLLLEDLQD 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1456	CDD:279015
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		PH	1495..1580	CDD:278594
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2122	CDD:279015	43/194 (22%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061	19/99 (19%)
ARHGEF3	NP_001122087.1	RhoGEF	158..334	CDD:395496	43/194 (22%)
		PH_RhoGEF3_XPLN	348..480	CDD:269976	17/78 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940