Protein Alignment trio and sestd1

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_001011359.1
• Gene: sestd1 / 496826
• XenbaseID: XB-GENE-977656
• Length: 696
• Species: Xenopus tropicalis
• Alignment Length: 794
• Identity: 177/794 - (22%)
• Similarity: 320/794 - (40%)
• Gaps: 164/794 - (20%)

  Fly     9 LLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNLGFTVIID 73
            :|.:|::::.||:||:|||.|.:|..|..  .|:...::|...|.||:|||||..|..|||||:|
 Frog     6 ILPILKKKLAFLSGGKDRRSGLILTIPLC--SDQTSMDELSVTLDYLLSIPSDKCKARGFTVIVD 68

  Fly    74 MRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKYK----FETTTVSIES 134
              |..:....|||::.:||....|.:..|.::|||.||.|:.......|.|    ||...||...
 Frog    69 --GRKSQWNVVKTVVLMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSGNK 131

  Fly   135 LNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDVPLA 199
            |.:.:|.:|||.:|.|...|||..|.:.||..|.|..::..:.|.:..:....::..
 Frog   132 LTRYIEPNQLTEEFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELAVINNGSDKGS-------- 188

  Fly   200 RHAIDHHNEMRKKI--TKLPIEDLD---MQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSAG 259
                  .||..:.:  ..||..|.:   ..|.:||:::.       |...|.....:...|....
 Frog   189 ------QNEKERSVDFNYLPSVDPETVLQTGHELLSELQ-------QRRFNGSDGGVSWSPMDDE 240

  Fly   260 QQSQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEK 324
            ..:||.               |.|.|..:...:|..:::.. .:.|:.:||:      .:|...:
 Frog   241 LLAQPQ---------------VMKLLDSLREQYTRYQEVCR-QRSKRTQLDE------IQQKVMQ 283

  Fly   325 MFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMN---VSVNIDRILAVAARLIESQH 386
            :.:|:.........:...||.:...:::||.:|::  :.|.:   .:|.::....:||.|.....
 Frog   284 VVNWLEGPGSEQLRTQWGIGDSIRASQALQQKHEE--IESQHSEWFAVYVELNQQIAALLNAGDE 346

  Fly   387 YAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAE-----------QYCNSVA--SWA 438
            .....:|||.|||.......|:.|:.|..:||.::.||..|:           ..|..||  ..|
 Frog   347 EDLVELKTLQQRLSDVCYRQASQLEFRQNLLQTALDFHSVAQDLSQQLDGLLGMLCVDVAPTDGA 411

  Fly   439 AACQASQPLPSDIQSLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPD 503
            |..|..:.|...::|::|.:   |.|.|                              ...|:.|
 Frog   412 AIQQTLKLLEEKLKSVDTGL---QGLRE------------------------------KGQGLLD 443

  Fly   504 HRKNSNNGSFNKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQE 568
            ...|..:.::.|    :.:.:..:...|:..::..:....:..|......||::.|.:.|...:|
 Frog   444 QITNQASWAYGK----DVSTENKDNVDHIQGIMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEE 504

  Fly   569 DVKQVLDWLKNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELAR-- 631
            |..|.:|||....:..|:.:..:|.:..:.::....|..|.:|||:||...::||.|...|.:
 Frog   505 DAAQAVDWLNELLDALLKTHIRLGDDSQETKILLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSL 569

  Fly   632 ------SGEADP--NEIYSVARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTD 688
                  ||:..|  |.::.          .|....|:|..||:||:.|:::.:.:      |:..
 Frog   570 RCTSRSSGDTLPKLNRVWK----------QFTITSEERVHRLEMALAFHSNAEKI------LQEC 618

  Fly   689 VSTDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQEMR-SLEYADNT----GS 748
            ....||.:..|..:.:|.:                      |:::|..:. .:.|.|.|    |:
 Frog   619 PDLGETVMDFEQFDEVEAV----------------------GKSVLDRLTVPVIYPDGTEQYFGT 661

  Fly   749 IAALEATLEKLNKQ 762
            .:.:.:|.|.:.::
 Frog   662 PSDMASTAEHIRER 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706	55/142 (39%)
		SPEC	314..>468	CDD:238103	38/169 (22%)
		SPEC	563..778	CDD:238103	45/215 (21%)
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1455	CDD:459876
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2121	CDD:459876
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
sestd1	NP_001011359.1	CRAL_TRIO_2	33..153	CDD:463965	45/123 (37%)
		Spectrin 1	272..378		23/113 (20%)
		SPEC	273..478	CDD:413338	45/249 (18%)
		Spectrin 2	381..494		23/149 (15%)
		SPEC	421..605	CDD:413338	44/230 (19%)
		Spectrin 3	500..602		27/111 (24%)