DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and sestd1

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_001011359.1 Gene:sestd1 / 496826 XenbaseID:XB-GENE-977656 Length:696 Species:Xenopus tropicalis


Alignment Length:794 Identity:177/794 - (22%)
Similarity:320/794 - (40%) Gaps:164/794 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNLGFTVIID 73
            :|.:|::::.||:||:|||.|.:|..|..  .|:...::|...|.||:|||||..|..|||||:|
 Frog     6 ILPILKKKLAFLSGGKDRRSGLILTIPLC--SDQTSMDELSVTLDYLLSIPSDKCKARGFTVIVD 68

  Fly    74 MRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKYK----FETTTVSIES 134
              |..:....|||::.:||....|.:..|.::|||.||.|:.......|.|    ||...||...
 Frog    69 --GRKSQWNVVKTVVLMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSGNK 131

  Fly   135 LNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDVPLA 199
            |.:.:|.:|||.:|.|...|||..|.:.||..|.|..::..:.|.:..:....::..        
 Frog   132 LTRYIEPNQLTEEFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELAVINNGSDKGS-------- 188

  Fly   200 RHAIDHHNEMRKKI--TKLPIEDLD---MQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSAG 259
                  .||..:.:  ..||..|.:   ..|.:||:::.       |...|.....:...|....
 Frog   189 ------QNEKERSVDFNYLPSVDPETVLQTGHELLSELQ-------QRRFNGSDGGVSWSPMDDE 240

  Fly   260 QQSQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEK 324
            ..:||.               |.|.|..:...:|..:::.. .:.|:.:||:      .:|...:
 Frog   241 LLAQPQ---------------VMKLLDSLREQYTRYQEVCR-QRSKRTQLDE------IQQKVMQ 283

  Fly   325 MFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMN---VSVNIDRILAVAARLIESQH 386
            :.:|:.........:...||.:...:::||.:|::  :.|.:   .:|.::....:||.|.....
 Frog   284 VVNWLEGPGSEQLRTQWGIGDSIRASQALQQKHEE--IESQHSEWFAVYVELNQQIAALLNAGDE 346

  Fly   387 YAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAE-----------QYCNSVA--SWA 438
            .....:|||.|||.......|:.|:.|..:||.::.||..|:           ..|..||  ..|
 Frog   347 EDLVELKTLQQRLSDVCYRQASQLEFRQNLLQTALDFHSVAQDLSQQLDGLLGMLCVDVAPTDGA 411

  Fly   439 AACQASQPLPSDIQSLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPD 503
            |..|..:.|...::|::|.:   |.|.|                              ...|:.|
 Frog   412 AIQQTLKLLEEKLKSVDTGL---QGLRE------------------------------KGQGLLD 443

  Fly   504 HRKNSNNGSFNKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQE 568
            ...|..:.::.|    :.:.:..:...|:..::..:....:..|......||::.|.:.|...:|
 Frog   444 QITNQASWAYGK----DVSTENKDNVDHIQGIMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEE 504

  Fly   569 DVKQVLDWLKNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELAR-- 631
            |..|.:|||....:..|:.:..:|.:..:.::....|..|.:|||:||...::||.|...|.:  
 Frog   505 DAAQAVDWLNELLDALLKTHIRLGDDSQETKILLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSL 569

  Fly   632 ------SGEADP--NEIYSVARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTD 688
                  ||:..|  |.::.          .|....|:|..||:||:.|:::.:.:      |:..
 Frog   570 RCTSRSSGDTLPKLNRVWK----------QFTITSEERVHRLEMALAFHSNAEKI------LQEC 618

  Fly   689 VSTDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQEMR-SLEYADNT----GS 748
            ....||.:..|..:.:|.:                      |:::|..:. .:.|.|.|    |:
 Frog   619 PDLGETVMDFEQFDEVEAV----------------------GKSVLDRLTVPVIYPDGTEQYFGT 661

  Fly   749 IAALEATLEKLNKQ 762
            .:.:.:|.|.:.::
 Frog   662 PSDMASTAEHIRER 675

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706 55/142 (39%)
SPEC 314..>468 CDD:238103 38/169 (22%)
SPEC 563..778 CDD:238103 45/215 (21%)
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1456 CDD:279015
PH1_Kalirin_Trio_like 1462..1584 CDD:270060
PH 1495..1580 CDD:278594
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
sestd1NP_001011359.1 CRAL_TRIO_2 28..153 CDD:372686 47/128 (37%)
Spectrin 1 272..378 23/113 (20%)
SPEC 273..478 CDD:351773 45/249 (18%)
Spectrin 2 381..494 23/149 (15%)
SPEC 421..605 CDD:351773 44/230 (19%)
Spectrin 3 500..602 27/111 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 61 1.000 Domainoid score I10330
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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