DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and net1

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_021330686.1 Gene:net1 / 493607 ZFINID:ZDB-GENE-041121-18 Length:605 Species:Danio rerio


Alignment Length:580 Identity:119/580 - (20%)
Similarity:204/580 - (35%) Gaps:181/580 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1243 NSSISSSSGDRHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIK 1307
            ||::.|.:.|.|...|...|            |.||:.|      :.||.:.|:..:.||....|
Zfish   151 NSTLWSETLDVHQKGTFSTK------------EIKRQEA------IFELSRGEQDLIEDLKLARK 197

  Fly  1308 CFLEEFRAGKSVPSALIGQEDV--IFGNIKEIHHFHQKIFLRELEK---YETMPEDVGHCFVTWA 1367
            .:.:..     :..:::.:|::  |||::......|:.: |.:|.|   .:.....:|...|.|.
Zfish   198 AYHDPM-----LKLSIMSEEELTAIFGDLDAYIPLHEDL-LDQLAKATGTDGTVRQIGKIVVDWL 256

  Fly  1368 SKFDMYVHYCKNKPTSNNLLVQ--HGGSFFEELQRRLE------VDHPLPAYLIKPVQRITKYQL 1424
            .:.:.|..||.|:..:..||.|  ......:.|||.||      :|  |.::|..|..|:.||.|
Zfish   257 PRLNAYRAYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLD--LWSFLDIPRSRLVKYPL 319

  Fly  1425 LLKDLLSCCEESH---GEIKEGLEVM------LNVPKKANDAMHLSLLENCDVSVDKLGEVVLQD 1480
            |||::|......|   |.:::.:.|:      :|:.|..::         |...:|||  ..|:|
Zfish   320 LLKEILRHTPPDHPDKGSLEQAISVIQAVLADINMKKGESE---------CQYYIDKL--EYLED 373

  Fly  1481 AF---QAWDTKQII-------RKGRERRVFLFELYLLFAKEVKESNVVKYQ-FKSKLMTTDMGIT 1534
            ..   :....|.::       :.|.:..||||...|:..:.|..::...:| ::..:...|:.:.
Zfish   374 KQKDPRIEQCKSLLCHGELRNKSGTKLHVFLFTEVLILTRPVTRNDRHCFQVYRQPIPVQDLVLE 438

  Fly  1535 EHIEGDETKFAVWTGRSPMLSDCRIV---------------LKATSLETKQIWVKKLREVMQE-- 1582
            :..:||......:.|........:.:               |:...:..||.|:..||..|..  
Zfish   439 DLQDGDVRMGGSFRGAFSNADKAKNIFRVRFQDASQGQSHTLQVNDVFHKQQWLNCLRNAMSTQK 503

  Fly  1583 --TCFSGTSLTLPKSP--AKHSGSSQRSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNKLGNQE 1643
              |......||.|.:.  ||...||..:...:|| :.||    |..|:..:.::..|:       
Zfish   504 DLTLSENEPLTTPATDVCAKRRSSSVSTVIQMDE-MDEN----CPRAAASAPSSPSSE------- 556

  Fly  1644 ATWVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPP 1708
                                        |||:                               |.
Zfish   557 ----------------------------EPPS-------------------------------PT 562

  Fly  1709 PGSHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWLPLMNRKGT 1768
            |      |.|:..::||:.|..| ....|.:||.|.            |:..||..||.|
Zfish   563 P------SATSTLSSSSSSSSIS-APIPSRKSKKDK------------RSLCPLGKRKET 603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1456 CDD:279015 46/190 (24%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 26/151 (17%)
PH 1495..1580 CDD:278594 17/100 (17%)
SH3_Kalirin_1 1643..1707 CDD:212786 3/63 (5%)
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
net1XP_021330686.1 RhoGEF 177..353 CDD:214619 45/189 (24%)
PH-like 367..500 CDD:327399 23/134 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3601
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.940

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