Protein Alignment trio and LOC4576783

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_061505953.1
• Gene: LOC4576783 / 4576783
• VectorBaseID: AGAMI1_013973
• Length: 1633
• Species: Anopheles gambiae
• Alignment Length: 1462
• Identity: 330/1462 - (22%)
• Similarity: 572/1462 - (39%)
• Gaps: 397/1462 - (27%)

  Fly   506 KNSNNGSFNKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQEDV 570
            :..|..|..:...|:|||   :..::|:.:.||||....:.||....|...|.|. ..|:|:..
Mosquito   338 RQHNRPSMMRVINQSPAA---KKCANVIMMNHQILRKPLSAEAPELLESGGLKQE-NCRMFKLQ- 397

  Fly   571 KQVLDWLKNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQN-TYSNAQKLLAAADELARSGE 634
                   |:|....|........:.|:............|.|.| :.||.|...:..:|     .
Mosquito   398 -------KSHTSTNLLTRHKSMNDIHRINQLFLDCKGDSNPASNISLSNRQNCNSTTNE-----S 450

  Fly   635 ADPNEIYSVARELELQVGSFAERVEQRR----------RRLDMAVIFYTHEKDVT------AWID 683
            .||....::..:.|...|   .|.|:.|          :||...   |..|.::|      ..:.
Mosquito   451 CDPIRSNNMTADRETTTG---HRFEKHRKSEPNKYLVHKRLSAR---YKTESNLTNTNTTEVTLP 509

  Fly   684 KLRTD------VSTDET---RLSQ--------ENLEGIERILQQYQRDQQESSVNVCLTTISQGE 731
            .:..|      :|.|:|   |:.|        .:.||:::::::...:.|:..:         |:
Mosquito   510 PVSPDNGNSYGLSGDDTISKRIRQIIKGQDHIGSTEGVDQLVEKSMNEAQKHGI---------GK 565

  Fly   732 ALLQEMRSLEYADNTGSIAALEATLEKLNKQKVELEELWSARKFRADLILRLRYFERDARLLSVQ 796
            ...:|.:.::.........:...:.|||...:.::.:....::..:.......|  ::.:..:..
Mosquito   566 GKNEEQQQVQVCSKKFQRLSKSKSTEKLIMDRNQIGDAAEGKEKNSKTSSTCGY--KNCKFSNCP 628

  Fly   797 MEMWSEELQHADLSRDYQ-KAEQLIRMHNESV--TEIQNA-----TYEVVQQG------------ 841
            |...|.....:..|.... |....:...:|.|  |.|.|.     ..|::..|
Mosquito   629 MSSSSSSSSASSTSSSVSCKTRARMEGGSEKVPSTAINNRPPPPDKLEIISNGKRTSIVSTDDGD 693

  Fly   842 -------------QDLL---QLFENAGF-ISMADATHTAQARIEYLLDFLRE------REIDLEE 883
                         :|.|   .|..::.| ..|.:||.|   .|:::.|..|.      ::||||.
Mosquito   694 MAKASKKESSACIKDQLVINNLLNSSTFNEKMNNATTT---DIKHMNDDSRVIITSKIKQIDLES 755

  Fly   884 MSEAKRAKLEQAVQLC-------QFQNDANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQ 941
            .|......|.|:.|.|       :|.|..||     ||            ..|:...|.:...::
Mosquito   756 NSMIIEKSLAQSPQNCRISSSRHKFWNHQNQ-----RN------------IKLKNNPQTKAYDDK 803

  Fly   942 FQI--AIEKTHTSAVQVKYRADALINANHY----DPLSIDEISDDVTKKWQQLVTYAEERHKLVT 1000
            ..|  .|:....:::::...:....|.|..    :|:|:...:|            ..:|    :
Mosquito   804 IDINNKIKNEENNSIKIFISSSTGANGNSCNVLPEPVSLISTTD------------VGDR----S 852

  Fly  1001 ASINFYKTAEQVCSVLDSLEREYKREDDWCDGGGGS---DKAQ--AIV----QLISKHQEQKEAF 1056
            :|.::..|:.  |.   |...|..::|.:||....|   ||.|  :||    ..||.:.......
Mosquito   853 SSCSYASTSS--CG---STGSESDKDDGYCDQSECSTIPDKQQPSSIVSTSSSTISSNSSCSNGS 912

  Fly  1057 LKACTLA----------------------------RRTAETFLK-------YANRSQQCYQYKGN 1086
            ...|:.:                            |.|::|.::       :.||:     |...
Mosquito   913 STVCSESTHVSNVTCANSLPGGNGSATTITNSGGNRYTSKTSIRLGCDGSLFLNRN-----YLEE 972

  Fly  1087 CEG---HVKSKLDKLLTQENQVLDYWTLRK--KSLDQC-------QQFVLFERSAK--QAIEWIH 1137
            .||   .|.|.||. ...||...|:   |:  .:::.|       |.|.  .||::  .:|:..:
Mosquito   973 VEGPSSPVTSDLDG-DDNENASSDF---RECFNTVNVCCCAPKKPQTFA--HRSSRLVSSIDMTN 1031

  Fly  1138 --NTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDI 1200
              :||::.|:  .||...|.......|:..|...: ..||...||
Mosquito  1032 ASSTGKSALA--CNLFTASAATDNNALQSDNALHN-KNETCACVK-------------------- 1073

  Fly  1201 KQWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNS 1265
                     ::::..|::::|..:.....|.....:.:.||  ::|:||..|          |||
Mosquito  1074 ---------KHRNSQNKIENYSSRPRSIEGPLDSGISISSD--TAITSSDSD----------LNS 1117

  Fly  1266 SNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEF---RAGKSVPSALIGQE 1327
            .::  .:.:|.|.|    :..::|||::|||.||.::.:.:|.:.:|.   .....||..|.|:.
Mosquito  1118 QSQ--TDADERKLK----RGHVLAELLETERIYVAEMGSILKGYKDEMLSEEMSSLVPPGLQGKS 1176

  Fly  1328 DVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASK-FDMYVHYCKNKPTSNNL---LV 1388
            |::|||:.|::.||..|||::||...:..|.|..|||..... |.:|.:||:|.|.|..|   ||
Mosquito  1177 DILFGNLHELYTFHNDIFLKDLENCISTTELVALCFVQRRDTFFRLYSYYCQNIPRSERLRETLV 1241

  Fly  1389 Q-HGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLL-----SCCEESHGEIKEGLEVM 1447
            . |  .|.:|.|::|....||.|||:|||||||||||||||||     ..|..   |:::.|:.|
Mosquito  1242 DTH--LFLQECQKKLGHKLPLAAYLLKPVQRITKYQLLLKDLLKFSDTGTCSR---ELQKALDCM 1301

  Fly  1448 LNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAW-DTKQIIR---KGRERRVFLFELYLLF 1508
            |.|.|..||:||...:......:.:.||:::||:||.| ::|:.:|   |.:.|.:||::..:||
Mosquito  1302 LVVLKCVNDSMHQIAITGFPADLSQQGELLMQDSFQVWTESKKDLRLRLKTQNRHIFLYQKAMLF 1366

  Fly  1509 AKEVKES--NVVKYQFKSKLMTTDMGITEHIEGDETKFAVW-TGRSPMLSDCRIVLKATSLETKQ 1570
            .|:..::  |...||||..|..:.:|:||.:.||..:|.|| .||..:.:     ::||::|.|.
Mosquito  1367 CKQGSKTGHNKSTYQFKHWLQMSQIGLTESVRGDSRRFEVWLQGRQEVHT-----IQATTIEIKN 1426

  Fly  1571 IWVKKLREVM--QETCFSG----------------TSLTLPK----SPAKHSGSSQRS------- 1606
            .||.:::.|:  |.....|                ||..:|:    :|.:...|.|:.
Mosquito  1427 KWVAEIKRVLLNQLEELKGEKIKQYGLNHKPLRHMTSWDVPQAVQGTPNRILSSDQQPTLQANGI 1491

  Fly  1607 --------SRDLDEQLTENDHDRCSLASFGSGNTTDSDNKLGN----------QEATWV------ 1647
                    ::|:..::...:.|....|:..|.::::.||:..|          .|.|.|
Mosquito  1492 GIGGMVGLAQDVVTRIAHMNDDSLLNATGISCSSSEHDNQESNAWSSDYSNSEDEFTTVEDSVVP 1556

  Fly  1648 ------VADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLK 1706
                  :|||.| .|::|:|:.:.:.||:::...||   :..|::     .|...||..|.:.|:
Mosquito  1557 GHKFVSLADYCA-MGNSEVSMKEAEVVELLKVGCAG---WWFVKV-----IATGLEGWAPAAYLE 1612

  Fly  1707 PPPGSHKHGSGTAANAASSAGSQKSDMQDQSN 1738
            |           .|...|...|.:|  ||:.|
Mosquito  1613 P-----------VARKNSRLRSARS--QDRLN 1631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103	39/248 (16%)
		SPEC	782..997	CDD:238103	48/270 (18%)
		SPEC	897..1119	CDD:238103	51/283 (18%)
		SPEC	1125..1226	CDD:197544	17/104 (16%)
		RhoGEF	1287..1455	CDD:459876	75/180 (42%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	40/130 (31%)
		SH3_Kalirin_1	1643..1707	CDD:212786	20/75 (27%)
		RhoGEF	1945..2121	CDD:459876
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
LOC4576783	XP_061505953.1	None