DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trio and Arhgef15

DIOPT Version :9

Sequence 1:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster
Sequence 2:	XP_011247414.1	Gene:	Arhgef15 / 442801	MGIID:	3045246	Length:	877	Species:	Mus musculus

Alignment Length:	629	Identity:	123/629 - (19%)
Similarity:	220/629 - (34%)	Gaps:	194/629 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1224 QLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNSSNKENKEIN-----EEKRKSARR 1283
            |..::..:|::...:|.||..| .::.|:..:...|....|:..:|...:.     |......||
Mouse   362 QTYRAAVLSEELWGVGEDGGPS-PANPGEAPTFSRLPGPRNTLWQELPAVRGSGLLESLSPQERR 425

  Fly  1284 KEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQE-DVIFGNIKEIHHFHQKIFLR 1347
            .:..:.|::.:|.:|:..|    :...:.|...:::...|..:: ..:|.|::.:....::....
Mouse   426 MQESLFEVVTSEASYLRSL----RLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQSVSERFLGT 486

  Fly  1348 ELEKYETMPEDVGHCFVTWA---SKFDMYVHYCKN---KPTSNNLLVQHGGSFFEELQR------ 1400
            .|.:..:.|.....|.|..|   ..|.:||.|.:|   :..:.:.|:.....|..||:|
Mouse   487 LLSRVRSSPHITDLCDVVHAHAVGPFFVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPK 551

  Fly  1401 --RLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEESHGEIKEGLEVMLNVPKKANDAMHLSLL 1463
              ||    |||::|:.|.||||:.::||:::||..||.... :|..:..|....|        ::
Mouse   552 CERL----PLPSFLLLPFQRITRLRMLLQNILSQTEEGSSR-QENAQKALGAVSK--------II 603

  Fly  1464 ENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVKESNVVKYQFKSKLMT 1528
            |.|...|.::.:           |:::||..:..|         |.| ||...:|.:..:.:|
Mouse   604 ERCSAEVGRMKQ-----------TEELIRLTQRLR---------FHK-VKALPLVSWSRRLEL-- 645

  Fly  1529 TDMGITEHIEGDETKF------AVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETCFSG 1587
                     :|:.|:.      .::|.|......|.::.....|
Mouse   646 ---------QGELTELGCRRGGVLFTSRPRFTPLCLLLFSDLLL--------------------- 680

  Fly  1588 TSLTLPKSPAKHSGSSQRSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYI 1652
              :|.||       |.||..                                        |.||.
Mouse   681 --ITQPK-------SGQRLQ----------------------------------------VLDYA 696

  Fly  1653 ATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLN-----PQHDDAAVQEGLVPVSVLKP---PP 1709
                  ..|:.:.|||    |..:|.|.|.|..|:     |.|  ..:|...:.|| |:|   ||
Mouse   697 ------HRSLVQAQQV----PDPSGPPTFRLSLLSNHQGRPTH--RLLQAASLSVS-LRPTMNPP 748

  Fly  1710 GSHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGF----------SGRNWLPLMN 1764
                |...:..:...|||.:.|..|......:..::.:.:..|.:          .|:.|.|
Mouse   749 ----HPLCSPLDQTCSAGWEPSPPQVPFPVPQTPSMRTVSVPRSYVQSHPHLPRLRGKVWSP--- 806

  Fly  1765 RKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQPGASP 1808
                 :||.|   :....:|:.|....|...|..:.|  |..:|
Mouse   807 -----RPPES---ICTRIQKHSRWHVSHGSTLCSKNN--PRQTP 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544	1/1 (100%)
		RhoGEF	1287..1456	CDD:279015	43/183 (23%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	19/127 (15%)
		PH	1495..1580	CDD:278594	13/90 (14%)
		SH3_Kalirin_1	1643..1707	CDD:212786	19/68 (28%)
		RhoGEF	1945..2122	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
Arhgef15	XP_011247414.1	RhoGEF	430..606	CDD:214619	44/192 (23%)
Arhgef15	XP_011247414.1	PH_ephexin	630..750	CDD:269929	39/218 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030