DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and Exn

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster


Alignment Length:2342 Identity:422/2342 - (18%)
Similarity:738/2342 - (31%) Gaps:824/2342 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   232 INAMAPPGGQAPTNSGGPDMDSGPSSAGQQSQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQE 296
            :|:.:....:|..:..|.|..:...:...|:.|:|.          .:..::|.|...    |.:
  Fly    58 VNSDSENNNRATCDKAGKDNPNPNQNPNSQANPNQN----------CSCESRAFRDFR----GVQ 108

  Fly   297 KLLMLWQH--KKVKLDQCFQWRLFEQDCEKMFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQK 359
            .|.:||..  |....|||                  |:......|...:|....:.||:     .
  Fly   109 TLRLLWSRRIKSASEDQC------------------HSPVHCHTSSSSLGTLKKLNKSV-----S 150

  Fly   360 FAVASMNVS---VNIDRILAV-AARLIESQHYAAQHIKTLAQRLDRTWK-----------DFAAG 409
            ..|.:.|.|   ...::.||. ||.|...|...|:| |.|.:..|..:|           ...:.
  Fly   151 CLVNAFNNSRDCATPEKTLAKRAASLHNLQDSQAKH-KQLHREKDNFYKYKNAEQAKMQAKLRSS 214

  Fly   410 LDERTAVLQLSVLFHHKAEQYC-------NS-----------VASWAAACQ--ASQPLPSDIQSL 454
            .||  |:|..|.....:.:..|       ||           ||...|..|  |.:|:......:
  Fly   215 ADE--AILNASETRAKRDDSGCLPGVKSYNSKALSAADKVAKVAKGEAKTQRRAEEPVGEAEVEV 277

  Fly   455 ETAIRTHQ--------SLYEAMCQA-------------------YTEVHSTS------KKLLYQL 486
            |...|..:        ||..|..|:                   ::.|.|::      :|..:: 
  Fly   278 EVEFRAKREHNRLEGLSLSAASAQSGGSSESLQTTTTSSSTPTTHSSVTSSTGRSGGRRKYSFK- 341

  Fly   487 DHLVQVCNQPPPPGVPDHRKNSNNGSFNKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKWH 551
            .|..:..:|...|.    |:.||..|.|            .|.|.|..:.||.            
  Fly   342 THAGKSYHQHHHPS----RRTSNMDSSN------------GGISMVAKLTHQF------------ 378

  Fly   552 QERLRLHQTLALRLFQEDVKQVLDWLKNHGEVFLRKNTGIGRNFHKARVYQTSH-DNFENVAQNT 615
                       ..:.|:|.| :|:.:|.:..|::.:.|.:.:...|    .||. ....|...|.
  Fly   379 -----------NEIIQKDAK-LLEQVKRNNGVWISRGTHVYKIVEK----PTSEGKGLPNADDNR 427

  Fly   616 YSNAQKLLAAADELARSGEADPNEIYSVARELELQVGSFAERVEQRRRRL----------DMAVI 670
            .|..|:.:...:.|.:......:| ..:.:.|||..||...|..:.:|.|          ::|::
  Fly   428 ISTVQRNIKKFERLEKPSVPLKSE-QLMRKHLELMRGSSLSRGPRIKRNLKLPPGSVGIPELAIV 491

  Fly   671 FYTHEKDVTAWIDKLRTDVSTDETR----------------LSQEN------------LEGIERI 707
                       .::|:|..|.::.:                |:|.|            .||.|..
  Fly   492 -----------SEELKTPTSEEQAKKPKSVQNESQPNHPEELNQSNDKPSDELDLIMGEEGDEEE 545

  Fly   708 LQQYQRDQQESSVNVCLTTISQGEALLQEMRSLEYADNTGSIAALEATLEKLNKQKVELEELWSA 772
            |:|.||..:.:|:                ...|.:....|..:|..:..:...:::|.::|....
  Fly   546 LRQKQRKHKYASI----------------YEKLRFTFAKGRKSASPSPTKAQIREEVSIDEESIK 594

  Fly   773 RKFRADLILRLRYFERDARLLSVQMEMWSEELQ---HADLSRDYQKAEQLIRMHNESVTEIQNAT 834
            .....|::.|...|..|   |..::...:|:|:   ||.|.....:|:..|....|:|       
  Fly   595 DSTSEDMVTRKEDFTLD---LPKEVIPRAEDLEDSSHALLVSPCFEADAKILDALEAV------- 649

  Fly   835 YEVVQQGQDL-LQLFENAGFISMADATHTAQARIEYLLDFLREREI------DLEEMSEAKRAKL 892
                    || |::......::.||.                |||:      |.|:......:.:
  Fly   650 --------DLKLKVLNPLNDVTTADG----------------ERELLLAANDDFEQRILPNSSFV 690

  Fly   893 EQAVQLCQFQND---ANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIEKTHTSAV 954
            .||... |:.|:   .||.::      ..||.:......:.|.:||.|..:     :|.|.....
  Fly   691 YQAANK-QYSNNQILLNQAVN------VTLVNAIEGEQMIMEQKQLMKVRD-----LELTERDID 743

  Fly   955 QVKYRA-------DALINANHYDPLS--IDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAE 1010
            |...||       |.|...:.|:|::  :||...:.  :...|.....::.:||.   :.|:|.|
  Fly   744 QPLKRAEKSPEKDDTLEPESLYEPITPVMDETKTEA--QTSSLFKIYTKKSELVE---DIYQTVE 803

  Fly  1011 QVCSVLDSLEREYKREDDWCDGGGGSDKAQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYAN 1075
            :..:|      |.| .::|.:|          .:.|:..||       ||.|   |.:.:..:|.
  Fly   804 EASTV------EVK-PNNWLEG----------YESIAGSQE-------ACPL---TYDGYESFAP 841

  Fly  1076 RSQQCYQYKGNCEGHV-KSKLDKL--LTQENQVLDYWTL------RKKSLDQCQQFVLFERSAKQ 1131
            ..........:..|.: ::..|:|  |.:..:||:...:      .|....:.::......:.|.
  Fly   842 EEVVTTPTTPSATGTLGRNTRDELPELPKPKRVLNKSPIPLRPAPPKPQAKESEEDENIYDTIKG 906

  Fly  1132 AIEWIH-------NTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKL-------- 1181
            ..|.:|       ::|||.|:            |:.:....|.:.|.:...|.||..        
  Fly   907 CYESMHCKATSSSSSGEATLT------------TDTISLSSNCYESISHIRRSRVATTQNQGHGS 959

  Fly  1182 ---LIQLA--------------DSLVEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSL 1229
               .|||:              :||.|...|.|..:....|||..|                .||
  Fly   960 AGSCIQLSSSGSTLTISSDHKTNSLYESSLAAAGCVVYGSASVGCR----------------SSL 1008

  Fly  1230 GMSQQQLLLGSDGN--SSISSSS--------------GDRHSDPTLEAKLNSSNKENKEINEEKR 1278
            |.|......|..|:  |||:.||              |...:|.|       :|:....:..|:.
  Fly  1009 GSSAGSRDSGKPGDKRSSIAGSSDNSDAWVDISDGEIGQATTDAT-------ANEAQFIVVRERF 1066

  Fly  1279 KSARRKEFIMAELMQTERAYVNDLATCIKCFLEEF------RAGKSVPSALI--GQEDVIFGNIK 1335
            |..|.:....::.::.:|.......:||:...:.:      ...|...:.|:  .|:....|.::
  Fly  1067 KPHRTRSPDWSKRIRDKRLQQKKAISCIEDDSDHYYETLSPLGNKRHSTQLVRQSQDGNRSGGVR 1131

  Fly  1336 EIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGGSFFEELQR 1400
            ..|        |..:.:......:|. .|..:..:|.:       .|.::   .||....:..||
  Fly  1132 SSH--------RRSKNHSASAHTLGE-HVVISDDYDSF-------ETDSD---DHGDGEPDLRQR 1177

  Fly  1401 RLE---VD---HPLPAYLIK---PVQRITKYQLLLKDLLSCCEESHGEIKEGLEVMLNVPKKAND 1456
            ...   ||   |.||    |   |..::.::....||.:|                   .||:..
  Fly  1178 NYNDSGVDMRNHRLP----KPPPPQNQVYEFVRKFKDFIS-------------------SKKSPK 1219

  Fly  1457 AMHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVKESNVVKYQ 1521
            .....|.||...|.                                    ||..|..:.....|:
  Fly  1220 GSQQKLYENTPAST------------------------------------LFYVECSKRTEDVYE 1248

  Fly  1522 FKSKLMTTDMGITEHIEGDETKFAVWTGRSPML-----------SDCRIVLKATSLETKQI-WVK 1574
                  .||.| .|.|...|||..|...::|:|           |..|..|..:|.:|||: .:.
  Fly  1249 ------NTDFG-PERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLA 1306

  Fly  1575 KLREVMQETCFSGTSLTLPKSPAKH------SGSSQRSSRDLDEQ-------------------- 1613
            ..|.........|:...||..|..|      ||.|.::...|.|.                    
  Fly  1307 PTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRR 1371

  Fly  1614 ----LTENDHDRCSLASFGSGNTTDSDNKLGNQEAT-WVVADYI---ATSGSNELSVSKGQQVEI 1670
                |..||.........|:.:..|.:.:|..::.| |.....:   ||:|:             
  Fly  1372 TTIGLRPNDPPPPPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGA------------- 1423

  Fly  1671 VEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQD 1735
                           ::|:.|:        ||:   |.|..|   .|.::..|.|...|.|.:  
  Fly  1424 ---------------VSPRGDE--------PVT---PTPSGH---GGVSSWYAESGLYQTSGI-- 1457

  Fly  1736 QSNRSKADALSSSTKRRGFSGRNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQ 1800
                    :::||      ||.:.:...|..|.....||:|               |:....|..
  Fly  1458 --------SVASS------SGSSGVSTGNEAGLGDELSSEP---------------HSLFSNEPL 1493

  Fly  1801 NQQPGASPATVLPSSQFPSSTQHPGGAGAGD-YEPDEEVGLELPPPMKPIQEPHLIANGPPAFAK 1864
            .|...|        ::..|.|:.....|:.| |   ||:||:.....:|:.:|.     |.|.  
  Fly  1494 YQMYSA--------AKLESITRDLEAHGSSDGY---EEIGLQAKAKPEPLVKPR-----PTAL-- 1540

  Fly  1865 DAKESSGNMASPGKMDGNPL-SEIEEIVKTTTEQHESNSRVDGGGGVENASTNGHGRSHDNNDES 1928
                   .:..|.......| |||.|::                                     
  Fly  1541 -------QLVEPKNGPSRTLWSEIPEVI------------------------------------- 1561

  Fly  1929 HTAV----SDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKM 1989
            |:.:    :.:..:|::.:   .|::::|.:|::.|:.:...:|......:|.:...:|     .
  Fly  1562 HSCILPTLTSRERSLQEAK---FEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKD-----R 1618

  Fly  1990 KLVFNNIKDIYE------------WHRDFFLRALRNCQKSPADLGPLIKRSATKFALYYTYCSN- 2041
            |.:|:.|..::|            |..:..|..|..|         :.:.:...|.:|..:|.: 
  Fly  1619 KALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRC---------IYEIAERHFHVYVAFCEHQ 1674

  Fly  2042 ----------KPLSEYIV-SAHYQYFDSIRQKLGHRLDLSNLIIKPVQRITKYELLIKEIIKATE 2095
                      |...|.:. ..|.:..::.....|  |:|.:.::.|:||||:..|||..:..   
  Fly  1675 GRMDRTLRRLKESKESLAFQQHLERLEASPSCCG--LNLHSFLMLPMQRITRLPLLIDAVFS--- 1734

  Fly  2096 GAGLYKEVPMLQEAYQQMKVVVKTVN-----------------DMMVVLRSLQDFDGEITAQGSL 2143
                 ||.|:.:|.|:..|:.:..|.                 ::..:.|.| :|...:.|    
  Fly  1735 -----KESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQL-EFPSHVRA---- 1789

  Fly  2144 LMQGPMNCVVDAAQKHR-----------------------------ELQVFLFQQIIIFADIEKT 2179
            |...|:. |..|..|.|                             .:..|||..:::..   |.
  Fly  1790 LAIAPVG-VPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLC---KR 1850

  Fly  2180 KNQYASPIFKY--RSHI------QLNHMQMKELGD-------CRFQIRSTDPKIPEMTIICQAAS 2229
            :.:....:|.|  ||.:      .|..:..|:|.|       ....:.:.|.|..|:.:.|.:.|
  Fly  1851 RGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVS 1915

  Fly  2230 QE 2231
            .:
  Fly  1916 DQ 1917

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103 38/196 (19%)
SPEC 563..778 CDD:238103 44/253 (17%)
SPEC 782..997 CDD:238103 47/236 (20%)
SPEC 897..1119 CDD:238103 47/242 (19%)
SPEC 1125..1226 CDD:197544 25/132 (19%)
RhoGEF 1287..1456 CDD:279015 29/185 (16%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 27/133 (20%)
PH 1495..1580 CDD:278594 23/96 (24%)
SH3_Kalirin_1 1643..1707 CDD:212786 9/67 (13%)
RhoGEF 1945..2122 CDD:279015 39/217 (18%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 26/146 (18%)
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 39/205 (19%)
PH_ephexin 1805..1931 CDD:269929 18/116 (16%)
SH3_ephexin1_like 1944..1998 CDD:212727
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3601
SonicParanoid 00.000 Not matched by this tool.
11.030

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