DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and CG15822

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_001137872.2 Gene:CG15822 / 38273 FlyBaseID:FBgn0035308 Length:1267 Species:Drosophila melanogaster


Alignment Length:1463 Identity:277/1463 - (18%)
Similarity:517/1463 - (35%) Gaps:359/1463 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 DLLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNLGFTVII 72
            |:|..||.|..:|:||.||:...:....|...........|:..|.||....|.:....|.:|::
  Fly     4 DVLNALQTRSAYLSGGFDRQKRIVFVVNAFNDLQLWNRRYLQVTLDYLKRSLSASVLQNGVSVVV 68

  Fly    73 DMRGNGN--CSTNVKTILKVLQEHFSANIH-NVVIIKPDNFWQKQRASISSHKYKFETTTVSIES 134
            :.:.:.:  ....|:.|..:    |..:|: ::.:::.:.||:|.....:..:.|.|...:|...
  Fly    69 NAQESSSRISRQQVRQIYAL----FGGDINVDLYLVRAEGFWEKHVEPCTKSQVKGEPLVLSKAR 129

  Fly   135 LNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDF----FWQAGDMADRIDDLQEDLNRNDFAED 195
            |.|.:|...|..:..|...:::..|...|.:|::|    ......|...:..|:|..:......|
  Fly   130 LFKFIEPQNLPEELGGTLQFNYDLWLQQRKSIDEFTKSHVQTLASMEKLLALLREHKSLRPAEAD 194

  Fly   196 VPLARHAIDH---HNEMRKKITKLPIEDLDMQGKKLLAKINAM-----APPGGQAPTN---SGGP 249
            |.|.:.|..|   .|::...|      ||   |..:||:.|.:     .||...||.:   :|.|
  Fly   195 VELKKCAQMHAGVQNDIETAI------DL---GNAILARFNEVYETHSPPPQAVAPASESPAGPP 250

  Fly   250 DMDSGPSSAGQQSQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQ 314
            .:.:..:|||...:|...       ||::....:...::..|...|..:...|......|.:..:
  Fly   251 PIAAHSASAGSPQKPLLP-------PDLACERTRIELRLNEIEKKQTAIRTAWLELLRSLREARE 308

  Fly   315 WRLFEQDCEKMFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEH---------------------Q 358
            ....|.....:.:|||...::.......:..:....::|:..|                     :
  Fly   309 LSTLEDGVSFVTNWILQEAELLLSRQRSVAGDVRGCEALRSAHDQLELECRETYGCYAELLYKIE 373

  Fly   359 KFAVASMNVSVNIDRILAVAARLIESQHYAAQHIKTLAQR--LDRTWKDFAAGLDERTAVLQLSV 421
            |||......|.::||               .|.:  |:||  :....:.||..|:.|..||..::
  Fly   374 KFAAERQASSKDMDR---------------CQDL--LSQRDFMQFVCRSFAKRLERRRNVLMTAL 421

  Fly   422 LFHHKAEQYCNSVAS-------------WAAACQASQPLPSDIQSL----ETAIRTHQSLYEAMC 469
            .||...:|:.:.:|:             |..|.|....|..:.:.|    ...:|..:.|.:.:.
  Fly   422 RFHRLLDQFEDLLATGNHVVEVDSRSLDWPEAEQLLMQLNKNQEMLGHVERELVREGEKLSDMLA 486

  Fly   470 QAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHRKNSNNGSFNKYERQNPAADYSEGASHVLA 534
            ....:......:|.|..: :.|:..|     :.:.|:.                           
  Fly   487 MPVKDALGRDLQLDYSAE-IAQLRRQ-----IDESRRR--------------------------- 518

  Fly   535 VIHQILSHHRTLEAKWHQERLRLHQTLALRLFQEDVKQVLDWLKNHGEVFLRKNTGIGRNFHKAR 599
              .|:..|...|      :||.|.|...:..::||.::..|||:....|.||.::.:|.|.|:.:
  Fly   519 --RQVCGHRLAL------QRLTLEQVTHIHAYEEDARRARDWLQELYAVLLRCHSHVGCNIHEIQ 575

  Fly   600 VYQTSHDNFENVAQNTYSNAQKLLAAADELARSGEADPNEIYS--------VARELELQVGSFAE 656
            :.:.....||...::.|....:||.|:..|....:.:|:...|        ::.||:....|...
  Fly   576 LQKDELQGFEETGRSIYHYGCQLLEASQTLRLCCKLEPSSFRSQSNSSQGFISDELQHTWHSLQS 640

  Fly   657 RVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETR--LSQENLEGIERILQQYQRDQ-QES 718
            ..:::..||.::.:|:   :.|.|:..:||      |.|  |::|    :...|||.||.| ..|
  Fly   641 VAQEQMTRLRVSAVFH---RSVEAYYRQLR------ELRPLLTKE----LSAQLQQQQRQQHNRS 692

  Fly   719 SVNVCLTTISQGEALLQ-EMRSL---------------EYADNTGSIAALEATLEKLNKQKVELE 767
            |..:.    |..||.|: |:..|               :.....|.:..|...|:|..|:...|:
  Fly   693 SSGIG----SDAEAELESELSPLGEMPPRLQRHLVAREQLLVEVGRMVRLGRLLKKRLKEPFVLD 753

  Fly   768 ELWSARKFRADLILRLRYFERDARLLSVQMEMWSEELQHA--DLSRDYQKAEQLIRMHNESVTEI 830
            .| :.::|| :|..:.:..|...:.:..:.|:.|..:...  ::....::.|      |:|:.|.
  Fly   754 AL-TGKRFR-NLFAKSKGDEEVEQEVGPRPEVPSIVVDEPPNEVEIPVEEGE------NKSLDEA 810

  Fly   831 ---QNATYEVVQQGQDLLQ-----LFENAGFIS-MADATHTA-----------QARIEYLLDFLR 875
               .||:..:..:.:||:|     |.|::..:| :.||.:.|           |...|   |:..
  Fly   811 AYQANASAPLASEEEDLVQSPPEILSESSSDLSRLLDAINEASKLPELSSEDGQGEDE---DYED 872

  Fly   876 EREIDLEEMSEAK----RAKLEQAVQLCQFQNDANQVISWIRNGEAMLVASFVTPNSLQEAEQLR 936
            |.:.:....|..|    :|.:|:.:.|.:.:.:.::|.|    |..:        .||.:.:.|.
  Fly   873 EDDDETASTSSVKTKIAKASIERDIILEETEEEEDEVDS----GPPL--------KSLDKIKALI 925

  Fly   937 KG------HEQFQIAIEKTHTSAVQV--------KYRADALINANHYDPLSID------------ 975
            :.      |..:......:|:....|        :...|..:.|   |.|.:|            
  Fly   926 RNDSETYPHSDYTDNETPSHSRTASVDSGAPDNPRLSGDFSVVA---DELPLDCTAPSPLHDSGR 987

  Fly   976 ------EISDDVTKKWQQLVTYAEERHKLVTASINFYKTA-EQVCSVLDSLEREYKREDDWCD-- 1031
                  ||..:......|:|....  ::|..|:|:....| .:|...||::.|:.::::....  
  Fly   988 TSSAGSEIPVETLPATVQVVPTGS--NELACAAISHKLGAIAEVAESLDAVIRDVQQQEGVVSNG 1050

  Fly  1032 -----GGGGSDKAQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHV 1091
                 ||.|..|..:|....|:..|. |:|..|                           .||:.
  Fly  1051 ISNVTGGHGIKKLGSIEDWQSRSTED-ESFATA---------------------------SEGNF 1087

  Fly  1092 --KSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVL--FE--RSAKQAIEWIHNTGE-AYLSSR-S 1148
              .|......|...:...|....|.|.|:.....|  ||  ......:....::.| :|.|.| .
  Fly  1088 TPNSHSSSFQTASGRTSSYIGSAKNSFDEADDSTLSTFEIPELPPSPVNMSFDSSEMSYFSDRQQ 1152

  Fly  1149 NLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQRYKD 1213
            .:....::...|:.:.|:: ..|.....|:..||:.|             .:.|.:.|       
  Fly  1153 RMKSEDQDSVAGMAELHSQ-SVTPTPDEEQQHLLLPL-------------PLPQAIES------- 1196

  Fly  1214 FSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNSSNKENKEINEEK- 1277
                 ||..|....:.|::           :.::....:.|:........|::...:...||.| 
  Fly  1197 -----DSEVEGFNLATGIT-----------TELAPRMSNAHTPEVSYTSANNTAPASTNPNESKP 1245

  Fly  1278 RKSARRKEFIMAELMQTERAYVNDLATCIKCFL 1310
            ..|.||.::           |.|.....||.||
  Fly  1246 PPSWRRSKY-----------YENITKQTIKGFL 1267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706 31/141 (22%)
SPEC 314..>468 CDD:238103 33/193 (17%)
SPEC 563..778 CDD:238103 57/241 (24%)
SPEC 782..997 CDD:238103 45/272 (17%)
SPEC 897..1119 CDD:238103 45/263 (17%)
SPEC 1125..1226 CDD:197544 18/104 (17%)
RhoGEF 1287..1456 CDD:279015 6/24 (25%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060
PH 1495..1580 CDD:278594
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
CG15822NP_001137872.2 SEC14 9..148 CDD:301714 31/142 (22%)
SPEC 298..526 CDD:295325 41/279 (15%)
SPEC 420..649 CDD:295325 46/269 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4240
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.810

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