Protein Alignment trio and GEFmeso

DIOPT Version :9

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Alignment Length: 1065
• Identity: 231/1065 - (21%)
• Similarity: 413/1065 - (38%)
• Gaps: 248/1065 - (23%)

  Fly  1179 VKLLIQLADSLVEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGN 1243
            |.:.:..|:.|.|...|:    |....|:| |..|...:   :..:|.:...::.:.|...|..:
  Fly   438 VPIKLPTAEQLAELEEAN----KLSAESLD-RLTDIKPK---FAARLSELARLNNRPLSSSSICS 494

  Fly  1244 SSISSSSGDRHSDPTLEAKLNSSN---------KENKEINEEKRKSARR-KEFIMAELMQTERAY 1298
            :|.|||||   ||..|..||.:::         :...|:.::....|.. .|....|::.:||::
  Fly   495 TSSSSSSG---SDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSF 556

  Fly  1299 VNDLATCIKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCF 1363
            |.||...||.:|:::   |......:.:..::|.||:||:.|: .:.|:.|......|..:..||
  Fly   557 VEDLGQVIKGYLQDW---KERACLRVDELQILFANIEEIYEFN-SMLLQRLINTGRDPGRIARCF 617

  Fly  1364 VTWASKFDMYVHYCKNKPTSNNLLVQ-----HGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQ 1423
            :.....||:|..||.:.|.:.:||.:     |..|.....|:.|:...||.:||:||||||.||.
  Fly   618 IDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYH 682

  Fly  1424 LLLKDLLSCCEESHGEIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAWDTK 1488
            |||..|     ..|.::||.:|..:.:.:.|::...:...:.....|.:|..::     ..|...
  Fly   683 LLLDSL-----RKHCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGIL-----DGWLGP 737

  Fly  1489 QIIRKG-------------RERRVFLFELYLLFAKEVKESNVVKYQFKSKLMTTDMGITEHIEGD 1540
            ::...|             ::|.|.||...|:..|:.::.   :.|||:.:...::.::||:.|:
  Fly   738 ELTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQKEDG---RLQFKTYISQNNLMLSEHLPGE 799

  Fly  1541 ETKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQR 1605
            .|.|.|.....|.   .:|.|.|.:.:.|:||.:.::.||.|      .|.:|           .
  Fly   800 PTSFYVIPFDEPR---HQIKLTARNRDQKRIWTQHIKGVMLE------KLDIP-----------M 844

  Fly  1606 SSRDLDEQLTENDHDRC--------SLASFGSGNT---TDSDNKLGNQEATWVVADY----IATS 1655
            .:::|..|| .|:.||.        ||.| ||.:|   .:..|.....|.....:.:    :|.|
  Fly   845 RAKELVYQL-GNEEDRTPDRSTWKWSLHS-GSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANS 907

  Fly  1656 GS-NELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTA 1719
            .| :..:.|..|:.|.:......:|   |.| |...||.|:|: |......:....:.|..:.|.
  Fly   908 SSFDSFNESLEQEEESISQAKPSKP---LAR-NNSLDDTALQK-LAAAMRYRKRDAAVKEETKTP 967

  Fly  1720 ANAASSAGSQKSDMQDQSNRSKADALSSSTK-RRGFSGRNWLPLMNRKGTDKPPSSKPLVKKPSE 1783
            .....     |.| ||.....:.:..|...: :|..|.::..|:.:.|...:...|.|.:...|
  Fly   968 VKEPC-----KCD-QDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKERSKSVPRIGGFS- 1025

  Fly  1784 KNLRTPQKHAEELAEQQNQQPGASPATVLPSSQFPSSTQHPGGAGAGDYEPDEEVGLELPPPMKP 1848
                     .:|.||::.:|...|.|::..|.  |..::.. ..|.|.:|..:.....:|..
  Fly  1026 ---------LDEEAEREREQDEDSAASLRGSK--PDLSERK-TKGKGFFEVKQYNHKTMPKK--- 1075

  Fly  1849 IQEPHLIANGPPAFAKDAKESSGNMASPGKMDGNPLSEIEEIVKTTTEQHESNSRVDGGGGVENA 1913
                  |||     .|..:.|:....|...||   |||.:....|..:..||...:...|.:|
  Fly  1076 ------IAN-----LKKQRSSTTKSCSRFYMD---LSEFDSSSSTVLKITESTEELRPDGEIE-- 1124

  Fly  1914 STNGHGRSHDNNDESHTAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDI 1978
                              ::.:||.|.:         ||::.|....||             :::
  Fly  1125 ------------------LAQEAATLDE---------STQDQYYSPDHE-------------TEL 1149

  Fly  1979 PMPEDLKGGKMKLVFNNIKDIYEWHRDFFLRALRNCQKSPA-----DL--GPLI------KRSAT 2030
            ..|.:......::|.:.:|:..|:.|.:..:..|  ::||.     |:  ||::      .||..
  Fly  1150 LSPAEKSKRDAQIVLDLLKNSKEFERIYNKQQKR--RESPVSPVSPDISRGPILPPPRPPSRSPP 1212

  Fly  2031 KFALYYTYCSNKPLSEYIVSAHYQYFDSIRQKLGHRLDLSNLIIKPVQRITKYELLIKEI---IK 2092
            ...|...  ..||:.|         .||:.:             :|:     ||.|::.:   .|
  Fly  1213 PLELEEQ--EKKPVEE---------VDSVSE-------------EPI-----YETLLRNVHVPYK 1248

  Fly  2093 ATEGAGLYKEVPMLQEAYQQMKVVVKTVNDMMVVLRS----LQDFDGEI---------------T 2138
            .:...|..|...:|::..:......:..:|.:.::.|    ||....|:               .
  Fly  1249 FSPVLGRAKSSQILKKRSKTAPAASRPESDYVTLVYSPEGVLQRVGEEVVQRDSCSSSTTSTSSN 1313

  Fly  2139 AQGSLLMQGP----MNCVVDAAQKH 2159
            ..||.|.:..    :|.:::|||:|
  Fly  1314 GSGSTLKRDSQSTVINLLMEAAQEH 1338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544	10/46 (22%)
		RhoGEF	1287..1456	CDD:279015	54/173 (31%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	29/134 (22%)
		PH	1495..1580	CDD:278594	22/84 (26%)
		SH3_Kalirin_1	1643..1707	CDD:212786	16/68 (24%)
		RhoGEF	1945..2122	CDD:279015	32/192 (17%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061	11/49 (22%)
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	54/173 (31%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	33/161 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840