DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trio and CG30456

DIOPT Version :9

Sequence 1:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster
Sequence 2:	NP_611188.3	Gene:	CG30456 / 36929	FlyBaseID:	FBgn0050456	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	767	Identity:	169/767 - (22%)
Similarity:	293/767 - (38%)	Gaps:	227/767 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   993 EERHK--LVTASINFYKTAEQVCSV---LDSLEREYKREDDWCDGGGGSDKAQAIVQLISKHQEQ 1052
            :|||.  ||::::.....|..|.||   ..|::..|....|       :|.:.....|:..|:.:
  Fly    38 QERHSSTLVSSNLESNDVARPVSSVSSSSSSIQLSYSVNSD-------TDSSYRHRSLLKMHEAE 95

  Fly  1053 KEAFL----------------KACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQ 1101
            ....|                .|....|:....|  .|.|:..|:         :|.:...|...
  Fly    96 SVGGLGTESTPESPMSPQTPDPALLDVRQKVHRF--EAFRTNICF---------IKQERHSLKLL 149

  Fly  1102 ENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYL-------------SSRSNLV-- 1151
            ||:       |..|         ||..::.     |:|..|..             ||||:.:
  Fly   150 ENR-------RHPS---------FEDQSED-----HHTPPATPPRRIRLPGLGSRGSSRSSSIPS 193

  Fly  1152 ---GISKEETEGLLKEHNEFRS---TAKE------TRERVKLLIQLADSLVEKGHAHASDIKQWV 1204
               ||.:..:|..:.:.::|.:   ||.|      |...|....::|||.|::.....|
  Fly   194 FQAGIHEVRSEDEVDQISDFETDSHTAAEEYLVVDTTSEVVPSEEVADSKVDQQQVQRS------ 252

  Fly  1205 ASVDQRYK----------DFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTL 1259
            .|.||..:          ||.....|...:..:.:|.:.:.|:             |..||
  Fly   253 ISADQSKEALTLPLKMRNDFPRNYRSTPRRKTEIIGTTNEHLV-------------GKFHS---- 300

  Fly  1260 EAKLNSSNKENKEINEEKR-KSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSAL 1323
               :.....|.:|:..|.| ||.:....|:.||::||.||||:|.|.|:.:...|:. |.:|..|
  Fly   301 ---VYQPKDEEEEVEIELRDKSDKCVHPILEELIKTEEAYVNNLFTGIENYGNIFQR-KDLPLGL 361

  Fly  1324 IGQEDVIFGNIKEIHHFHQKIFL-------RELEKY--ETMPEDVGHCFVTWASKFDMYVHYCKN 1379
            .|::..:||||::|..||:..||       |:|::.  |.:.....|||..       ||.:..|
  Fly   362 RGKKYDLFGNIEQIAEFHRDEFLPMLQRNRRDLKRLFDEFLQFLDQHCFYG-------YVIFTMN 419

  Fly  1380 KPTSNNLLVQHGGSFFEELQRRLEVDHPL--PAYLIKPVQRITKYQLLL----------KDLL-- 1430
            |..|..|...: .::|..:  |||.|..|  .::|::|:||:.:|.|||          :|::
  Fly   420 KQKSLKLCDLY-KNYFTSI--RLERDDKLGINSFLVQPIQRMARYPLLLTQFINTFFKNRDIVMK 481

  Fly  1431 ----SCCEESHGEIKEGLEVMLNVPKKANDAMHLSLLENC-DVSVDKLGEVVLQDAFQAWDTKQI 1490
                |||     .:::.|..:|..   .|::..::.:.:| :.:|...|:....:.||..|.|
  Fly   482 PLIESCC-----RLEKRLRALLTT---TNESEIINDIVDCHEFNVYYQGKFRKVNEFQVLDHK-- 536

  Fly  1491 IRKGRERRVFLFELYLLFAKEVKESNVVKYQFKSKLMTTDMGITEHIEGDETK-FAVWTGRSPML 1554
            :::....:||:|:..:::. |:|..|::   |..:.....:||:.     :|| |.::..|...
  Fly   537 LKRSYRSKVFIFDKCIIYT-EIKGKNLL---FHGRYPCEHIGISA-----KTKSFTLYYERRKQ- 591

  Fly  1555 SDCRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDLDEQLT-END 1618
            .:|........:   .||:..:|:::                   :..:....:.|.|:.: |||
  Fly   592 QECEFTADPVQI---AIWLDLIRDMI-------------------NNYANEERQKLQERYSREND 634

  Fly  1619 HDRCSLASFG---SGNTTDSDNKLGN-------------QEATWVVADYIAT 1654
            |......||.   ..|...||:.:||             ...||    |.||
  Fly   635 HLHRKAPSFSLYRDSNRFSSDSGIGNIWIMPKADEDTISNRTTW----YAAT 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103	2/3 (67%)
		SPEC	897..1119	CDD:238103	28/146 (19%)
		SPEC	1125..1226	CDD:197544	29/137 (21%)
		RhoGEF	1287..1456	CDD:279015	58/195 (30%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	24/123 (20%)
		PH	1495..1580	CDD:278594	17/85 (20%)
		SH3_Kalirin_1	1643..1707	CDD:212786	5/12 (42%)
		RhoGEF	1945..2122	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
CG30456	NP_611188.3	RhoGEF	326..470	CDD:279015	52/154 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462261
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0689
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22826
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840