Protein Alignment trio and Arhgef40

DIOPT Version :9

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_038949404.1
• Gene: Arhgef40 / 361034
• RGDID: 1308093
• Length: 1520
• Species: Rattus norvegicus
• Alignment Length: 1041
• Identity: 220/1041 - (21%)
• Similarity: 382/1041 - (36%)
• Gaps: 290/1041 - (27%)

  Fly   802 EELQ-----HADLSRD-----YQKAEQLIRMHNESVTEIQNATYEV------------------- 837
            ||||     |.|||.:     :|:..:|..:....:|.::.|..|:
  Rat   653 EELQWDLGGHRDLSPNHWAEIHQEVARLCTLCQGVLTSVRQAIEELEGAAESKEEESVGMPEPLQ 717

  Fly   838 -VQQGQDLLQLFENAGFISM-ADATHTAQARIEYLLDFLREREID-----LEEMSEAKRAKLEQA 895
             |.....|..|..|.|.|.| ..:||:  :::|.....:..:|:|     |..:|..:..:.||.
  Rat   718 KVLADPRLTALQRNGGAILMRLRSTHS--SKLEGPGPAVLYQEVDEAIHQLVRLSNLRVQQQEQR 780

  Fly   896 VQLCQFQNDANQVISWIRN-GEAMLVASFVTP-NSLQEAEQLRKGHEQFQIAIEKTHTSAVQVKY 958
            .:|.|.|    :|:.|:.. ||..| |||..| |||...::.......|...::
  Rat   781 QRLRQVQ----EVLQWLSGPGEEQL-ASFTIPGNSLSVLQETELRFRAFSTEVQ----------- 829

  Fly   959 RADALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLD---SLE 1020
              :.|:.|.  :.|:::|   |:|.  |:::...|:|             .|||.|.|.   .|:
  Rat   830 --ERLVQAR--EALALEE---DITS--QKVLDIFEQR-------------LEQVESGLHRALRLQ 872

  Fly  1021 REYKREDDWCDGG----GGSDKAQAIVQLISKHQEQKEAFLKACTLARR---TAETF-----LKY 1073
            |.:::..:|.|.|    .|:...             :||.|.|..|.|.   :|.||     |..
  Rat   873 RFFQQAHEWVDEGCARLAGAGPG-------------REAVLAALALRRAPEPSAGTFQEMRALAL 924

  Fly  1074 ANRSQQCYQYKGNCEGHVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHN 1138
            ...|....:..|.|....:....::..|..:.....:.|::..|..        |:..|....|:
  Rat   925 DLGSPAALREWGRCRARCQELERRIQQQLGEEASPRSHRRRRADSA--------SSAGAQHGAHS 981

  Fly  1139 TGEAYLS-------------SRSNLVGISKE-ETEGLLKEHNEFRSTAKETRERVKLLIQLADSL 1189
            ...:..|             |..:|....:: |.|||     |....|.....|..|:..|..:.
  Rat   982 PSPSLSSLLLPSSPGPRAAPSHCSLTPCGEDYEEEGL-----ELAPEADGRPPRAVLIRGLEVTS 1041

  Fly  1190 VEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLL----GSDGNSSISSSS 1250
            .|.                         :|..|.        .::.:||    |.||...|.:
  Rat  1042 TEV-------------------------VDRTCS--------PREHVLLGRAGGPDGPWGIGT-- 1071

  Fly  1251 GDRHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVN-----------DLAT 1304
                  |.:|.|        :.|:.::|        :::||:..|:.|:.           :|..
  Rat  1072 ------PRMERK--------RSISAQQR--------LVSELIDCEQEYITTLNEPVPPPGPELTP 1114

  Fly  1305 CIKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASK 1369
            .::|   .:.|..||.              :.:..||...||:||:.....|..:|.||:....:
  Rat  1115 GLRC---TWAAALSVR--------------ERLRSFHGTHFLQELQGCTAHPLRIGACFLRHGDQ 1162

  Fly  1370 FDMYVHYCKNKPTSNNLLVQHGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCE 1434
            |::|..:.|::....:.|.    :....::..:|....||..|.:|::::.:|..||::||   .
  Rat  1163 FNLYAQFVKHRHKLESGLT----ALTPSVKGSMEGSPCLPRALQQPLEQLARYAQLLEELL---R 1220

  Fly  1435 ESHGE-------IKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIR 1492
            |:..|       ::..::::.....:..|.:.:..:..|::.:.:.|:::.:|.|    |....|
  Rat  1221 EAGPELSSERQALRAAVQLLQEQEARGRDLLAVEAVRGCEIDLREQGQLLHRDPF----TVICGR 1281

  Fly  1493 KGRERRVFLFELYLLFAK-EVKESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTGRSPMLSD 1556
            |...|.|||||..|||:| :..|.....:.:|....|.|||:||:|......|.:|..|.....
  Rat  1282 KKCLRHVFLFEDLLLFSKSKGSEGGSETFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRARE- 1345

  Fly  1557 CRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDLDEQLTENDHDR 1621
             ...|:|||.|||..|...:.:::..             .|.|       :::|..|
  Rat  1346 -AYTLQATSPETKLKWTSSIAQLLWR-------------QAAH-------NKELRVQ-------- 1381

  Fly  1622 CSLASFGSGNTTDSDNK-LGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPTAG-EPDFCLV 1684
             .:.|.|.||....|.| ||.:..:.::....|.:.:: ::||   ..|...|...| .|..|.:
  Rat  1382 -QMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRAS-VAVS---SFEHAGPSLPGLSPGACSL 1441

  Fly  1685 --RLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKS-DMQDQSNRSKADALS 1746
              |:..:..|..|::    :|:..||.......||..     |.|.:.| .:|..:..|...|||
  Rat  1442 PARVEEEAWDLDVKQ----ISLASPPASETLDSSGDV-----SPGPRNSPSLQSPNPGSSTPALS 1497

  Fly  1747 S 1747
            |
  Rat  1498 S 1498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103	54/232 (23%)
		SPEC	897..1119	CDD:238103	52/238 (22%)
		SPEC	1125..1226	CDD:197544	18/114 (16%)
		RhoGEF	1287..1456	CDD:279015	35/186 (19%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	37/122 (30%)
		PH	1495..1580	CDD:278594	30/85 (35%)
		SH3_Kalirin_1	1643..1707	CDD:212786	12/66 (18%)
		RhoGEF	1945..2122	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
Arhgef40	XP_038949404.1	PHA03247	<251..446	CDD:223021
		SPEC	789..967	CDD:413338	48/224 (21%)
		RhoGEF	1083..1242	CDD:413383	36/190 (19%)
		PH_puratrophin-1	1241..1376	CDD:270062	40/160 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910