DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and sestd1

DIOPT Version :10

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_878301.2 Gene:sestd1 / 360133 ZFINID:ZDB-GENE-030801-1 Length:714 Species:Danio rerio


Alignment Length:817 Identity:189/817 - (23%)
Similarity:328/817 - (40%) Gaps:189/817 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNLGFTVIID 73
            :|.:|::::.||:||:|||.|.:|..|....:..:  |:|...|.||:.|||:..|..|||||:|
Zfish     6 ILPVLKKKLAFLSGGKDRRSGLILTIPLCTEQTSM--EELSTTLDYLLGIPSEKCKARGFTVIVD 68

  Fly    74 MRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKYK----FETTTVSIES 134
              |..:....|||::.:||....|.:..|.::|||.||.|:.......|.|    ||...||...
Zfish    69 --GRKSQWNIVKTVVLMLQNVIPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANK 131

  Fly   135 LNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDVPLA 199
            |.:.:|..|||.:|.|..||||..|.:.||..|.|..::..:.|.:..:.|: .:...||.    
Zfish   132 LTRYIEPCQLTDEFGGSLLYDHLDWVNKRLVFEKFTKESTSLLDELIVINEN-EKGSQAEK---- 191

  Fly   200 RHAIDHHNEMRKKITKLPIEDLD---MQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSAGQQ 261
                |..:|.    ..||..|.:   ..|.:||:::......|.:    .||             
Zfish   192 ----DRSSES----NILPSFDPETVLQTGHELLSELQQRRFNGSE----GGG------------- 231

  Fly   262 SQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEKMF 326
                      ||....|...::.|.|.:::     |||...:.:..|..:..:.|......|:: 
Zfish   232 ----------GGGTAWSPMDDELLAQPQVM-----KLLDSLREQYTKYQEVCRQRSKRSQLEEI- 280

  Fly   327 DWILHNRDVFQ-MSYVE------------IGHNYSVAKSLQDEHQKFAVASMN---VSVNIDRIL 375
                 ...|.| ::::|            ||.:...:::||.:|::  :.|.:   .:|.::...
Zfish   281 -----QTKVMQVVNWLEGPGTDQLRTQWGIGDSIRASQALQQKHEE--IESQHSEWFAVYVELNQ 338

  Fly   376 AVAARLIESQHYAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAE-----------Q 429
            .:||.|..........:|.|.|:|.......|:.|:.|..|||.:..||..|:           .
Zfish   339 QIAALLSAGDEEDLMELKGLQQQLSDVCYRQASQLEFRQNVLQSAYEFHMTAQDLSQQLDGLLGM 403

  Fly   430 YCNSV--ASWAAACQASQPLPSDIQSLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQV 492
            .|..|  |..||..|..:.|...::|:|:|::|.:...:|:                 ||.:   
Zfish   404 LCADVAPADGAAIQQTLKHLEEKLKSVESALQTLREKGQAL-----------------LDQM--- 448

  Fly   493 CNQPPPPGVPDHRKNSNNGSFNKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRL 557
                           ||..||: |.:: ...:..|...|:.:|:..:....:..|......||::
Zfish   449 ---------------SNQTSFS-YGKE-VGVENKENIDHIHSVMEDMQLRKQRCEDMVDVRRLKM 496

  Fly   558 HQTLALRLFQEDVKQVLDWLKNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKL 622
            .|.:.|...:||..|.::||....:..|:.:..:|.:..:.:|....|..|.:|||:||...::|
Zfish   497 LQMVQLFKCEEDASQAVEWLGELLDALLKTHIRLGDDSQETKVLLEKHKKFVDVAQSTYDYGRQL 561

  Fly   623 LAAADELAR--------SGEADP--NEIYSVARELELQVGSFAERVEQRRRRLDMAVIFYTHEKD 677
            |.|...|.:        ||:..|  |.::.          .|....::|:.||:||..|:|..:.
Zfish   562 LQATVVLCQSLRCTTRSSGDTLPRLNRVWK----------QFTVTSDERQHRLEMASAFHTAAEK 616

  Fly   678 VTAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQEMR---- 738
            :      :|......|..:..|..|.:|.:                      |:.||..:.    
Zfish   617 I------VRESPELAELLVDVEAYEEVETL----------------------GKGLLDRLTVPVI 653

  Fly   739 ----SLEYADNTGSIAALEATLE---KLNKQKVELEE 768
                |.::..:.|.:|:...::.   ||.::|..|:|
Zfish   654 FPDGSEQFFGSPGDMASSAESIRERMKLVEEKRFLQE 690

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706 53/142 (37%)
SPEC 314..>468 CDD:238103 39/182 (21%)
SPEC 563..778 CDD:238103 48/227 (21%)
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1455 CDD:459876
PH1_Kalirin_Trio_like 1462..1584 CDD:270060
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2121 CDD:459876
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
sestd1NP_878301.2 CRAL_TRIO_2 33..153 CDD:463965 44/123 (36%)
COG4913 242..>438 CDD:443941 45/208 (22%)
Spectrin 1 275..381 22/113 (19%)
SPEC 383..607 CDD:413338 57/270 (21%)
Spectrin 2 384..497 28/149 (19%)
Spectrin 3 503..605 26/111 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 691..714 189/817 (23%)
Blue background indicates that the domain is not in the aligned region.

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