Protein Alignment trio and Vav

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Alignment Length: 778
• Identity: 162/778 - (20%)
• Similarity: 264/778 - (33%)
• Gaps: 246/778 - (31%)

  Fly  1554 LSDCRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQR-----SSRDLDEQ 1613
            ||.||   |...|....|               |.:|.|  ||.:.|.|.:.     .|.||:.:
  Fly   132 LSQCR---KVQQLHPDLI---------------GFNLQL--SPTERSHSDEAIYKDLHSTDLNMR 176

  Fly  1614 LTEN-DHDRCSLASF----GSGNTTDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEP 1673
            .|.: |....|.|.:    ....:.|.::.:..:..|..:.|||..|.||
  Fly   177 KTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTEDIDDYIEDSLSN--------------- 226

  Fly  1674 PTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQDQSN 1738
                   .|...::...:||.|:..|     |....|||                    :::.|.
  Fly   227 -------MCDSTIDNDAEDAGVETPL-----LSDCQGSH--------------------VRELSF 259

  Fly  1739 RSKADALSSSTKRRGFSGRNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQ 1803
            ....|.:||:|                             ...|.....||:.:|     :|:|.
  Fly   260 DLALDVVSSTT-----------------------------DGASNAVTPTPESYA-----RQSQS 290

  Fly  1804 PGASPATVLPSSQFPSSTQHPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIANGPPAFAKDAKE 1868
            |.|:.|..:|.|..|.                        |||     ..|::....:.:....|
  Fly   291 PLAAAAPSVPVSAAPG------------------------PPM-----GRLVSTSSSSSSLLVSE 326

  Fly  1869 SS-------------GNMASPGKMDGNPLSEIEEIVKT----TTEQHESNSRVDGGGGVENASTN 1916
            |.             .:|||.........||.:|.|..    .|.|.::...|.    .:|.:.|
  Fly   327 SQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVT----TDNIACN 387

  Fly  1917 GHGRSHDNNDE---------------SHTAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNG 1966
            |.|..|.|..|               |.||.|   .:.::|..|..||:.||..|:..|..:...
  Fly   388 GTGYDHTNTKEEEVYQDLCALHRTSRSQTASS---TSFEQRDYVIRELIDTESNYLDVLTALKTK 449

  Fly  1967 YMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFFLRALRNCQKSPADLGPLIKRSATK 2031
            :|.         |:...|...:::|:|..|:::.:.|.. ||..||.      .|.|..|....:
  Fly   450 FMG---------PLERHLNQDELRLIFPRIRELVDIHTK-FLDKLRE------SLTPNAKVKMAQ 498

  Fly  2032 --------FALYYTYCS-NKPLSEYI--VSAHYQYFDSIRQKLGH-----RLDLSNLIIKPVQRI 2080
                    |.:|..:|| .....:|:  |....|..|.:.||...     :|.|.:::..|:|||
  Fly   499 VFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRI 563

  Fly  2081 TKYELLIKEIIKATEGAGLYKEVPMLQEAYQQM----------------KVVVKTVNDMMVVLRS 2129
            .||.||:.:::|.|  :.|:.:...|:.|.:.|                .|:::.|.|.:..:..
  Fly   564 LKYHLLLDKLVKET--SPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHL 626

  Fly  2130 LQDFDG-EITAQGSLLMQGPMNCVVDAAQKHRELQVFLFQQIIIFA---DIEKTKNQYASPIFKY 2190
            ||:.:| ::...|.||:.|.::......||.:....|:|.:|:|..   .|:....||.     |
  Fly   627 LQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYT-----Y 686

  Fly  2191 R-SH------IQLNHMQMKELGDCRFQIR-STDPKIPEMTIICQAASQENYAGWRDMLNKILQ 2245
            | ||      ::.:|.:.....|.||:.: ....|..:........|:.....||..|.:.::
  Fly   687 RDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAME 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1455	CDD:459876
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	7/29 (24%)
		SH3_Kalirin_1	1643..1707	CDD:212786	13/63 (21%)
		RhoGEF	1945..2121	CDD:459876	48/207 (23%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061	29/128 (23%)
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050	2/2 (100%)
		RhoGEF	428..602	CDD:459876	47/191 (25%)
		PH_Vav	624..753	CDD:269930	29/131 (22%)
		C1_VAV	759..810	CDD:410360
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:473055