DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and Vav

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster


Alignment Length:778 Identity:162/778 - (20%)
Similarity:264/778 - (33%) Gaps:246/778 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1554 LSDCRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQR-----SSRDLDEQ 1613
            ||.||   |...|....|               |.:|.|  ||.:.|.|.:.     .|.||:.:
  Fly   132 LSQCR---KVQQLHPDLI---------------GFNLQL--SPTERSHSDEAIYKDLHSTDLNMR 176

  Fly  1614 LTEN-DHDRCSLASF----GSGNTTDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEP 1673
            .|.: |....|.|.:    ....:.|.::.:..:..|..:.|||..|.||               
  Fly   177 KTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTEDIDDYIEDSLSN--------------- 226

  Fly  1674 PTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQDQSN 1738
                   .|...::...:||.|:..|     |....|||                    :::.|.
  Fly   227 -------MCDSTIDNDAEDAGVETPL-----LSDCQGSH--------------------VRELSF 259

  Fly  1739 RSKADALSSSTKRRGFSGRNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQ 1803
            ....|.:||:|                             ...|.....||:.:|     :|:|.
  Fly   260 DLALDVVSSTT-----------------------------DGASNAVTPTPESYA-----RQSQS 290

  Fly  1804 PGASPATVLPSSQFPSSTQHPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIANGPPAFAKDAKE 1868
            |.|:.|..:|.|..|.                        |||     ..|::....:.:....|
  Fly   291 PLAAAAPSVPVSAAPG------------------------PPM-----GRLVSTSSSSSSLLVSE 326

  Fly  1869 SS-------------GNMASPGKMDGNPLSEIEEIVKT----TTEQHESNSRVDGGGGVENASTN 1916
            |.             .:|||.........||.:|.|..    .|.|.::...|.    .:|.:.|
  Fly   327 SQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVT----TDNIACN 387

  Fly  1917 GHGRSHDNNDE---------------SHTAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNG 1966
            |.|..|.|..|               |.||.|   .:.::|..|..||:.||..|:..|..:...
  Fly   388 GTGYDHTNTKEEEVYQDLCALHRTSRSQTASS---TSFEQRDYVIRELIDTESNYLDVLTALKTK 449

  Fly  1967 YMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFFLRALRNCQKSPADLGPLIKRSATK 2031
            :|.         |:...|...:::|:|..|:::.:.|.. ||..||.      .|.|..|....:
  Fly   450 FMG---------PLERHLNQDELRLIFPRIRELVDIHTK-FLDKLRE------SLTPNAKVKMAQ 498

  Fly  2032 --------FALYYTYCS-NKPLSEYI--VSAHYQYFDSIRQKLGH-----RLDLSNLIIKPVQRI 2080
                    |.:|..:|| .....:|:  |....|..|.:.||...     :|.|.:::..|:|||
  Fly   499 VFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRI 563

  Fly  2081 TKYELLIKEIIKATEGAGLYKEVPMLQEAYQQM----------------KVVVKTVNDMMVVLRS 2129
            .||.||:.:::|.|  :.|:.:...|:.|.:.|                .|:::.|.|.:..:..
  Fly   564 LKYHLLLDKLVKET--SPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHL 626

  Fly  2130 LQDFDG-EITAQGSLLMQGPMNCVVDAAQKHRELQVFLFQQIIIFA---DIEKTKNQYASPIFKY 2190
            ||:.:| ::...|.||:.|.::......||.:....|:|.:|:|..   .|:....||.     |
  Fly   627 LQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYT-----Y 686

  Fly  2191 R-SH------IQLNHMQMKELGDCRFQIR-STDPKIPEMTIICQAASQENYAGWRDMLNKILQ 2245
            | ||      ::.:|.:.....|.||:.: ....|..:........|:.....||..|.:.::
  Fly   687 RDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAME 749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1456 CDD:279015
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 7/29 (24%)
PH 1495..1580 CDD:278594 7/25 (28%)
SH3_Kalirin_1 1643..1707 CDD:212786 13/63 (21%)
RhoGEF 1945..2122 CDD:279015 49/208 (24%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 29/128 (23%)
VavNP_001097030.1 CH 20..132 CDD:278723 162/778 (21%)
RhoGEF 428..603 CDD:279015 47/192 (24%)
PH_Vav 624..753 CDD:269930 29/131 (22%)
PH 641..749 CDD:278594 25/112 (22%)
C1_1 761..804 CDD:278556
SH2_Vav_family 824..934 CDD:198193
SH3 940..993 CDD:302595
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45462266
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.