DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and quo

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_001004109.2 Gene:quo / 321031 ZFINID:ZDB-GENE-030131-9944 Length:1987 Species:Danio rerio


Alignment Length:1804 Identity:373/1804 - (20%)
Similarity:613/1804 - (33%) Gaps:634/1804 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 TLLQERVVFLTGGRDRRGGPLL---------CFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNL 66
            :|||..::.|.|||||.|..::         ..|      ::.|.:|.|||.||.|||....:.|
Zfish   747 SLLQLGIICLPGGRDRAGRAVVEVYGGRNGWISP------QVSPLELCRLLLYLHSIPRSEVREL 805

  Fly    67 GFTVIIDMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKY---KFETT 128
            |.||:||.|.....|...|::|.|.::...| :|.::::...:      |:....|:   :.:..
Zfish   806 GLTVVIDSRKCPLTSVFYKSLLMVQEQALHA-VHTILMLVDKD------ANPRPEKHPGLQIDVV 863

  Fly   129 TVSIESLNKIVESHQLTGDFEGQQLYDHQQWTD--ARLAIEDFFWQAGDMADRIDDLQEDLNRND 191
            | |:::|:|.|:.||||.|..|...|.|:.|..  .:|::.....:|..........:.|:.|.|
Zfish   864 T-SLKALHKTVDGHQLTSDLSGSFPYSHEDWLQFHQKLSLFQIELEAASSLLHTAIRRLDVKRTD 927

  Fly   192 FAEDVPLARHAIDHHNEMRKKITKLPIED-----LDMQGKKLLAKINAMAPPGGQAPTNSGGPDM 251
            .|:||   :..|   .|.|..: |:.:||     |..:|..:||::..      :....:...|.
Zfish   928 TAKDV---QSCI---QEQRSSM-KMVLEDTRLVALQREGGAILARMRR------EESRFAHSEDF 979

  Fly   252 -DSGPSSAGQQSQPSQQSRSVGGNPDMSAAVNKALRQIE---LIHTGQEKL--LMLWQHKKVKLD 310
             ||..|......|..:...:      :....|::|:.:|   |:...|:.|  :..|...:.:| 
Zfish   980 RDSLESVTCLYDQVEESVHT------LVMKSNQSLQHLEHVLLLRETQDSLHTIQKWCDAEERL- 1037

  Fly   311 QCFQWRLFEQDCEKMFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRIL 375
                |:..:.|.||...                    .:.:.|||.......|..|....: .::
Zfish  1038 ----WQKDKDDAEKTLQ--------------------KIQQRLQDTQTLLRQAKENKERGM-LLI 1077

  Fly   376 AVAARLIESQHYAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAA 440
            ....|..:..||.    :|.|.|.      :..|...|.....|      |||:           
Zfish  1078 KDVERKSKGTHYP----ETDAFRC------YTTGFKTRMTGFLL------KAEE----------- 1115

  Fly   441 CQASQPLPSDIQSLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHR 505
                  ..||:|       |...||. .|:   |..|..|:.:..|||:                
Zfish  1116 ------RKSDLQ-------TSVDLYR-FCE---EASSLVKECMEYLDHM---------------- 1147

  Fly   506 KNSNNGSFNKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQEDV 570
            |:||:                                  .:...|.          :|..|::  
Zfish  1148 KSSNS----------------------------------PMSVCWS----------SLHAFEQ-- 1166

  Fly   571 KQVLDWLKNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGEA 635
                                        |....|..:|::.:           ||..|....|..
Zfish  1167 ----------------------------RFQHFSPQHFQDRS-----------AALLERLPDGIW 1192

  Fly   636 DPNEIYSVARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQEN 700
            ..|.:.:..|::             |:|..::....:|| ||            |.||.:|:.  
Zfish  1193 MWNAVQTQCRDI-------------RQRLSEILQAAHTH-KD------------SQDEAQLNP-- 1229

  Fly   701 LEGIERILQQYQRDQQESSVNVCLTTISQGEALLQEMRSLEYADNTGSIAALEATLEKLNKQKVE 765
                  :..|.|....|...|..||.:...|               ||                 
Zfish  1230 ------VSGQTQNRAAEQGDNETLTYLQSAE---------------GS----------------- 1256

  Fly   766 LEELWSARKFRADLILRLRYFERDARLLSVQMEMWSEELQHADLSRDYQKAEQLIRMHNESVTEI 830
                    ||  :.::.....|:.|..:...:|...:|.:|...::|  |......|||||.:..
Zfish  1257 --------KF--EQVMTSSVHEQSASRIQQSVECTEQETRHLHETKD--KLHNASSMHNESTSHA 1309

  Fly   831 QNATYEVVQQGQDLLQLFENAGFISMADATHTAQARIEYLLDFLREREIDLEEMSEAKRAKLEQA 895
            |.:....||:.             ||...|:.....               ..|.:...:.::::
Zfish  1310 QQSVQCTVQKA-------------SMLQETNNTSRN---------------PSMHKDSASHIQES 1346

  Fly   896 VQLCQFQNDANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIEKTHTSAVQVKYRA 960
            || |..||.::                      |.|.:.:             :|       :.:
Zfish  1347 VQ-CTDQNTSH----------------------LHEPQAI-------------SH-------HPS 1368

  Fly   961 DALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLEREYKR 1025
            |..:..:|:.    ...|||..:|..::       ||       |.:||            .|| 
Zfish  1369 DRKLKEHHHK----HSHSDDDLRKSGRI-------HK-------FGQTA------------HYK- 1402

  Fly  1026 EDDWCDGGGGSDKAQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEGH 1090
                                         .|:::     ::||:.|:       .|:|       
Zfish  1403 -----------------------------VFIRS-----QSAESCLR-------GYRY------- 1419

  Fly  1091 VKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISK 1155
                                    ::..|:                       ..:.::.||.|.
Zfish  1420 ------------------------NIPLCK-----------------------TDAAASCVGASL 1437

  Fly  1156 EETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQRYKDFSNRMDS 1220
            |.....|.:|:.|.|:|                                       ..||.:..|
Zfish  1438 EGLSSELNQHDSFCSSA---------------------------------------SGFSQKCSS 1463

  Fly  1221 YCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNSSNKENKEINE-----EKRKS 1280
            .|                ||:.:     .||.|.||       |:..|:.:.:.:     |...:
Zfish  1464 DC----------------GSEDH-----GSGVRCSD-------NAFTKQEESVCKPECILENTST 1500

  Fly  1281 ARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIF 1345
            |.:.:.||.||:|||:.||..||..::.::.|... ..||..|.||..:||||::::..|||..|
Zfish  1501 ALKLQRIMQELLQTEQEYVRALAYVVENYMPELER-PDVPQDLRGQRGLIFGNLEKLRDFHQHHF 1564

  Fly  1346 LRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGGSFFEELQRRLEVDHPLPA 1410
            ::|||.....|..||.||:.....|.:|..|.||||.|.|||:|||..||::.|:.|:....|.:
Zfish  1565 IQELELCLEKPFSVGRCFLKHKESFGLYALYSKNKPRSENLLIQHGKDFFKQKQQLLKDALDLSS 1629

  Fly  1411 YLIKPVQRITKYQLLLKDLLSCC------EESHGEIKEGLEVMLNVPKKANDAMHLSLLENCDVS 1469
            ||:||||||:||.|||:|||..|      |....||...|.::....:..|:.:.:..:..|||:
Zfish  1630 YLLKPVQRISKYSLLLQDLLRECECVTNAELQRTEIHTALNIIQFQLRHGNNLLAMDDIYGCDVN 1694

  Fly  1470 VDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVKESNVVK--YQFKSKLMTTDMG 1532
            :.:.|:::.||.|.....|    |...|.:|||:..:||:| .::::|..  |.:|....|:|:|
Zfish  1695 LKEQGQLIRQDEFLLTFRK----KKCYRHIFLFQDLILFSK-TRKTDVGNDTYIYKQSFKTSDIG 1754

  Fly  1533 ITEHIEGDE-TKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKSP 1596
            :| |..||. ..|.:|..|..  :....||:|.|.|.|:.|.:.|..::.|.......:.:.:  
Zfish  1755 MT-HNSGDSGLCFEIWFRRRK--TQDTYVLQAASREVKESWTRDLERILWEQAIHNREIRMQE-- 1814

  Fly  1597 AKHSGSSQRSSRDL--DEQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYIATSGSNE 1659
            ....|...:...|:  .|....:....|.|...| |.:....|.:|:...|       ::||| :
Zfish  1815 RVFMGIGHKPFMDIKPSEMAISDRAINCVLTGRG-GVSVLRLNSIGSASGT-------SSSGS-Q 1870

  Fly  1660 LSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQE--GLVPVSVLKPPPGSH------KHGS 1716
            .|.|.|.          |.|....|......|...:||  |::....|....|:|      ...|
Zfish  1871 SSCSSGW----------GSPSTSAVCPVGGDDVRYIQETSGILEEDDLDQESGNHSTLVASSESS 1925

  Fly  1717 G-------TAANAASS--AGSQKSDMQDQSNRSKADALSSSTKRRGFSG 1756
            |       |:|::.||  .|..:....:...:.|.|.|.::.:.|..||
Zfish  1926 GESVSCFSTSAHSCSSVIGGDCEHTPSELGKQHKQDHLKTTNQTRDQSG 1974

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706 46/150 (31%)
SPEC 314..>468 CDD:238103 27/153 (18%)
SPEC 563..778 CDD:238103 32/214 (15%)
SPEC 782..997 CDD:238103 33/214 (15%)
SPEC 897..1119 CDD:238103 26/221 (12%)
SPEC 1125..1226 CDD:197544 13/100 (13%)
RhoGEF 1287..1456 CDD:279015 73/174 (42%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 38/124 (31%)
PH 1495..1580 CDD:278594 28/87 (32%)
SH3_Kalirin_1 1643..1707 CDD:212786 15/65 (23%)
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
quoNP_001004109.2 SMC_N <894..>1314 CDD:330553 114/687 (17%)
RhoGEF 1507..1680 CDD:306973 73/173 (42%)
PH_puratrophin-1 1673..1808 CDD:270062 39/142 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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