DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and Mcf2

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_008771798.1 Gene:Mcf2 / 317598 RGDID:1566098 Length:1110 Species:Rattus norvegicus


Alignment Length:1374 Identity:302/1374 - (21%)
Similarity:511/1374 - (37%) Gaps:406/1374 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   496 PPPPG-----------------------VPDHRK---NSNNGSFNKYERQNPAADYSEGASHVLA 534
            |||.|                       .|..||   |.:||:|..:.:..|..           
  Rat    16 PPPAGSPPAPALASPWLAFRNLPKAASRAPRTRKRQLNPDNGTFVPFTQTIPVQ----------- 69

  Fly   535 VIHQILSHHRT-LEAKWHQERLRLHQTL-----ALRLFQEDVKQVLDWLKNHGEVFLRKNTGI-- 591
             :...::.||. :..|:.:..|.|.|.:     .|.|..:|:        ||   ||.::...  
  Rat    70 -VDMAMALHRVRIAEKYGKNYLCLLQAVFLAETGLLLQLKDI--------NH---FLMQDIAFLS 122

  Fly   592 -GRNFHKARVYQTSHD-NFENVAQNTYSNAQKLLAAADELARSGEADPNEIYSVARELE----LQ 650
             ||....|.:.....: ||..:.:...:   |:|.....:||...:|......:.|.::    |:
  Rat   123 GGRGRDNAWIITFPENCNFRCIPEEVIA---KVLNYLTSIARQSGSDSRFTIILDRRMDTWSSLK 184

  Fly   651 V------GSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIERILQ 709
            :      .||.       ..|.:.::...     |:::.:..||:.   .|.|||          
  Rat   185 ISLQKISASFP-------GNLHLVLVLRP-----TSFLQRTFTDIG---FRFSQE---------- 224

  Fly   710 QYQRDQQESSVNVCLTTISQGEALLQEMRSLEYADNTGSIAALEATLEKLNKQKVELEELWSARK 774
                |.......|.|:::|.         .|.|.|:......|..||:..:.:       |    
  Rat   225 ----DFMLKLPVVMLSSVSD---------LLTYIDDKQLTPELGGTLQYCHSE-------W---- 265

  Fly   775 FRADLILR--LRYFERDARLLSVQMEMWSEELQHADLSRDYQKAEQLIRMHNESVTEIQNATYEV 837
                :|.|  :..|....:.::..::.:..||...:|..|....|:::....|....::|....|
  Rat   266 ----IIFRNAIEKFAVTVKEMAQMLQSFGTELAETELPDDIPSIEEILAGRAERYHLLKNDLTTV 326

  Fly   838 VQQGQDLLQLFENAGFISMADATHTAQAR-------IEYLLDFLREREIDLEEMSEAKRAKLEQA 895
            .::|:.||...:.........::|.....       |:.||..:.:.|...:...|..:.|:||.
  Rat   327 TKEGKVLLMNLQVPDTEENLSSSHECPQHINGDWQTIKKLLAQVHDMETAFDGFWEKHQLKMEQY 391

  Fly   896 VQLCQFQNDANQVISWIRNGEAML----VASFVTPNSLQEAEQLRK------------------- 937
            :||.:|:.:..:|::.:   |.:|    ....||.|..|..::|:|                   
  Rat   392 LQLWKFEQEFQEVVTQV---EFLLSQQRELGDVTGNLAQVKQRLKKIEILDDKSQELLAKGRIVI 453

  Fly   938 --GHEQFQIAIEKTHTSAV--------QVKYRADALINANHYDPLSIDEISDDVTKKWQQLVTYA 992
              ||:     :...|..|:        :::|.:|.|:|                           
  Rat   454 LHGHK-----LASNHHYALDLICQRCNELRYLSDILVN--------------------------- 486

  Fly   993 EERHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCDGG------GGSDKAQAIVQLISKHQE 1051
            |.|.|.:..|..|            .:.|..::....||.|      .|.||.|      :|...
  Rat   487 EIRSKRIQLSRTF------------KMHRLLQQARQCCDQGECLLANRGMDKFQ------TKEDA 533

  Fly  1052 QKEAFLKACTLARRTAETFLKYA----NRSQQCYQYKGNCEGHVKSKLDKLLTQENQVLDYWTLR 1112
            ||         |.:..:.||:.|    |...:..|:          :.|.||:.|        |:
  Rat   534 QK---------ALQDVDNFLQMAMPFINYDIENLQF----------EFDVLLSPE--------LK 571

  Fly  1113 KKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRE 1177
            .:.           ::.::.:|.|.:..|    ::.|...|||:..||.::.    ...|.|:..
  Rat   572 AQM-----------KNIQRKLENIRSVFE----NQQNAYKISKDRPEGAVQR----MIPAPESVM 617

  Fly  1178 RVKLLIQLADSLVEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDG 1242
            |.:.:. .:...|..|:           |..|..|.||        :::||....|.|    |:.
  Rat   618 RARTIF-FSPKHVGIGY-----------SFFQACKIFS--------KVKKSWRQIQAQ----SNV 658

  Fly  1243 NSSISSSSGDRHSD--PTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATC 1305
            ....:..|.:::.|  |.|::.|:.                 .|..::.||:|||||||.:|.|.
  Rat   659 KVQATQDSQEKNFDQPPKLDSSLDI-----------------LKNHVLNELIQTERAYVRELFTV 706

  Fly  1306 IKCFLEEF---RAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWA 1367
            :..:..|.   :....:|..|..::||:|||:.||:.||..||:..||.....||.||.||:...
  Rat   707 LLGYRSEMDNPQMFDLMPPLLRNKKDVLFGNMAEIYEFHNNIFMSRLEDCSDAPERVGPCFLERK 771

  Fly  1368 SKFDMYVHYCKNKPTSNNLLVQHGG-SFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLS 1431
            ..|.||..||:|||.|..:..::.. :||:|.||:|:....|.:||:||||||||||||||:||.
  Rat   772 EDFQMYAKYCQNKPRSELIWRKYSECAFFQECQRKLKHRLGLDSYLLKPVQRITKYQLLLKELLK 836

  Fly  1432 CCEESHG--EIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAW--------D 1486
            ..:|..|  ::||.|:.||.:.|..||:||.:.:.....:::.||:::||.||..|        .
  Rat   837 YSKEGEGTTKLKEALDSMLELLKSVNDSMHQTAINGYVGNMNDLGKMILQGAFSVWVGHRKGATK 901

  Fly  1487 TKQIIR-KGRERRVFLFELYLLFAKEVKES-----NVVKYQFKSKLMTTDMGITEHIEGDETKFA 1545
            .|...| |..:|.:||:|..::|.|...||     ....|.||..|...:.|||||::||..||.
  Rat   902 MKDFARFKPMQRHLFLYEKAVMFCKRRFESGEGADRYPSYSFKHCLKMEEAGITEHVKGDNRKFE 966

  Fly  1546 VWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVM---QETCFSGTSLTLPKSPAKHSGSSQRSS 1607
            :|.|....:    .:::|.:::.|.:|:|::|.::   ||...:.|.                  
  Rat   967 IWYGEKEEI----YIVQAPNIDVKMLWLKEIRNILLKQQELLTAKTQ------------------ 1009

  Fly  1608 RDLDEQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVE 1672
               .:||::.|            ...........||.|.:.|            |..|.:||...
  Rat  1010 ---QDQLSDQD------------QLPPQQQNAEKQEETLLNA------------VEAGAEVEQAS 1047

  Fly  1673 PPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQDQS 1737
            ..........||:...   :.....|::|.:            .||||.|.....|...:..:..
  Rat  1048 AMMEVREAALLVQAEA---NCTTWNGMLPCT------------EGTAATAEHPCNSLSPNSDNGE 1097

  Fly  1738 NRSKADALS 1746
            :||:..::|
  Rat  1098 DRSQMRSMS 1106

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103 40/228 (18%)
SPEC 782..997 CDD:238103 44/256 (17%)
SPEC 897..1119 CDD:238103 47/264 (18%)
SPEC 1125..1226 CDD:197544 19/100 (19%)
RhoGEF 1287..1456 CDD:279015 75/174 (43%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 40/138 (29%)
PH 1495..1580 CDD:278594 28/89 (31%)
SH3_Kalirin_1 1643..1707 CDD:212786 11/63 (17%)
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
Mcf2XP_008771798.1 SEC14 119..259 CDD:214706 31/180 (17%)
SPEC 399..590 CDD:295325 47/285 (16%)
RhoGEF 685..862 CDD:238091 76/176 (43%)
PH-like 869..1000 CDD:302622 38/134 (28%)
PH 884..997 CDD:278594 36/116 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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