DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trio and RGD1563354

DIOPT Version :9

Sequence 1:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster
Sequence 2:	XP_006235524.1	Gene:	RGD1563354 / 311592	RGDID:	1563354	Length:	1198	Species:	Rattus norvegicus

Alignment Length:	698	Identity:	146/698 - (20%)
Similarity:	245/698 - (35%)	Gaps:	202/698 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKP----EDLRRLLSYLISIPSDAAKNLGFTVII 72
            ||..|:..|.||||:.|.||| ..:|.......|    .::..|||||.|:|....|..|..|:|
  Rat   575 LLHSRIACLPGGRDKVGRPLL-LVSTAEEAWEAPWCTASEVAELLSYLCSVPRLEDKAKGLLVVI 638

  Fly    73 DMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISS---HKYKFETTTVSIES 134
            |.| .|.....:...|:.:|....|:|..|:::       .::|||..   ...:.|..| |:::
  Rat   639 DAR-KGPPRPGLVIALQSIQALPPASISKVLLL-------GEKASILQLPVRSVQVEVLT-SLKA 694

  Fly   135 LNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDVPLA 199
            |...|:.:||....||...|.|.:|.       .||       .::|....||::..     .|.
  Rat   695 LRNHVDPNQLPEALEGPFPYHHSEWV-------QFF-------QKLDPFLTDLHQAS-----ALL 740

  Fly   200 RHAIDHHNEMRKKITKLPIEDLD---MQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSAGQQ 261
            :.:|   .|..|......:|:..   .:.|:|:..:  :..||..|....||..:.|
  Rat   741 QASI---QEFEKGEPPGGVEEATRCLSKSKELMESV--LRDPGLLALQREGGTTLAS-------- 792

  Fly   262 SQPSQQSRSVGGNPDM-------SAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFE 319
              ..|::..:..|||:       :|..|....|:.::.|...:||...: .:|:|..      .|
  Rat   793 --LQQEASGLNANPDVRDHLMEAAALYNLVDDQLHVLVTASNQLLRRLE-LRVRLGH------LE 848

  Fly   320 QDCEKMFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVAARLIES 384
            ....::.||:.             |..   ::.||      |:|.:|          |.|..:|.
  Rat   849 TAIHQVSDWMR-------------GEG---SRCLQ------ALAPVN----------VCAGTVEK 881

  Fly   385 QH--YAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQP- 446
            .|  :....::..||        :..||:....|.||........|.....:.::|:..||.|.
  Rat   882 VHADFEDFFLQVAAQ--------YRQGLELSKQVAQLGTAEEGAGETELPDLVAFASTQQAFQAR 938

  Fly   447 -----LPSDIQ--SLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDH 504
                 :.::.|  .|||.:..|:     ..:..:..|:..|.||.||
  Rat   939 LTHFYMAAERQRTDLETLLHLHR-----FRRKMSRFHTDCKDLLTQL------------------ 980

  Fly   505 RKNSNNGSFNKYERQNPAADYSEGASHVLAVIH-QILSHHRTLEAKWHQERLRLHQTLALRLFQE 568
                   |..|..:.:|...           || ::..:.:.|.:::..|:|     ||::|
  Rat   981 -------SLGKAVKASPGDQ-----------IHLRLHCYLKRLASEFQTEKL-----LAMKL--- 1019

  Fly   569 DVKQVLDWLKNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQN--TYSNAQKLLAA------ 625
                         :|......|:|:...:..  ...|...:|:.:.  .|....::.||
  Rat  1020 -------------QVASLSQPGLGQELWEEA--WERHQKIQNLLRKALAYCPCPEVPAAYSAHID 1069

  Fly   626 ADELARSGEADPNE-----------IYSVARELELQVGSFAERVEQRR 662
            ....|..|:..|.|           |.:|.|.|:.|....|.:.||.|
  Rat  1070 QSRPAAKGQGLPREVGSKWDRSLQDILAVDRVLKSQRSPRAPQGEQNR 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706	44/145 (30%)
		SPEC	314..>468	CDD:238103	30/163 (18%)
		SPEC	563..778	CDD:238103	22/119 (18%)
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1456	CDD:279015
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		PH	1495..1580	CDD:278594
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2122	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
RGD1563354	XP_006235524.1	PHA03247	<303..570	CDD:223021
RGD1563354	XP_006235524.1	Mating_C	1012..>1168	CDD:289506	26/129 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810