DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and Ccdc141

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_003749542.2 Gene:Ccdc141 / 311134 RGDID:1593250 Length:1530 Species:Rattus norvegicus


Alignment Length:1616 Identity:297/1616 - (18%)
Similarity:528/1616 - (32%) Gaps:609/1616 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   690 STDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQEMRSLEYADNT-GSIAALE 753
            |.||||          ::|..:                   |.||.::::||  |.. |.:...:
  Rat    56 SQDETR----------KLLHDH-------------------ELLLAKLKALE--DRVWGLLQEAD 89

  Fly   754 ATLEKLNKQKVE--------LEELWSARKFRADLILRLRYFERDARLLSVQMEMWSEELQHA--- 807
            .|.| .||::.|        |.|.|      |.|:..|   ||...||.:..|.:...|:.|   
  Rat    90 RTAE-ANKEQSEVYDAMAQTLGEAW------ATLVSML---ERRRELLGLTSEFFQSALEFAIKI 144

  Fly   808 DLSRDY----------QKAEQLIRMHNESVTEIQNATYEVVQQGQ---DLLQLFENAGFISMADA 859
            |.:.|:          :..:.|:.:|:....|:...:..::.:.|   |.::.|:..|....::.
  Rat   145 DQAEDFLQNPHEFESAEALQSLLLLHDRHAKELLERSLVLLNKSQQLTDFIEKFKCDGSPVNSEL 209

  Fly   860 THTAQA---RIEYLLDFLREREIDLEEMSEAKRAKLEQAVQLCQFQNDANQVISW----IRNGEA 917
            ...||:   :|:.||:.|::|...|::..:.:|.:|.|.:|||.:....:||..|    ||:.:.
  Rat   210 IQGAQSSCLKIDSLLELLQDRRRQLDKHLQQQRQELSQVLQLCLWDQQESQVSCWFQKTIRDLQE 274

  Fly   918 MLVASFVTPNSLQEAEQLRKGHEQFQIAIEKTHTSAVQVKYRADALINANHYDPLSIDEISDDVT 982
            ..:.|     ||.:.::|.:.||...|..::...:..::|.:|..::            :|.|:|
  Rat   275 QSLGS-----SLSDNKELIRKHEDLTIKAKEWDLAMEKLKSQALGIL------------LSKDLT 322

  Fly   983 KKW------QQLVTYAEE-------RHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCDGGG 1034
            :|.      |:|....||       |...:|.:.:|:.:|.:...||..:|...|..        
  Rat   323 EKEHLQLSNQKLNRLQEEFGRLMVDRKAWLTMAHDFFTSANEAFDVLGKVEDYLKLL-------- 379

  Fly  1035 GSDKAQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCE--GHVKSKLDK 1097
             ..:..::..|.:||:|.......:...|.:...|.:...:..:.  |..|..|  |.::.::|:
  Rat   380 -KSEGLSLPALAAKHEELHREIKDSTAAALQKGRTLISQVDSCRA--QVTGIHETMGRIQKRVDR 441

  Fly  1098 LLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNL-VGISKEETEGL 1161
             |:|:......:.|:|:.|.......|  |..:.:::      |..|...:.| ||.|..|:|.:
  Rat   442 -LSQQCTAHQEFALKKQQLATSVDDYL--RKVEMSVQ------EMRLVLATTLDVGSSPSESEKI 497

  Fly  1162 LKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQRYKDFS--NRMDSY--- 1221
            |.::.|....||||...::...::.   .||.....:::......|.:..::.|  :|..||   
  Rat   498 LNKYLELDIQAKETAHALEAAAKIT---TEKNELELNEVALLPFKVKRLEEELSTLSRSVSYRSQ 559

  Fly  1222 -----------CEQLEKSLGMSQQQLLLGS------DGNSSISSSSGDRH-----------SDPT 1258
                       .|::|:.|...::..|..|      |...:..|:|.:|.           .|.:
  Rat   560 VLQTYIAFRKSSEEVEEQLQSLKEFYLTESPWEDEDDAVVTCQSNSAERKWQLFLKKSFLTQDLS 624

  Fly  1259 LE-AKLNSSNKENKEIN----------------------------------------------EE 1276
            || ..|.|..|||:.:|                                              :|
  Rat   625 LEFLNLISMAKENEILNVKKEMHIVENVMEKQTNGREELSRLRMAWHLKAMEGKPVKERWETFKE 689

  Fly  1277 KRKSARRKEFIMAELMQTERA----------------------YVNDLATCIKCFLEEFR--AGK 1317
            |.|.......::.|::....|                      .:..|...::..::|:.  :|:
  Rat   690 KLKKTTHNVKLLHEVLMPVSALDLGGNLQSMSDLRRRWIAMQPQLQQLHEDVQQIMKEWEVLSGQ 754

  Fly  1318 SVPSALIGQEDVIFGNIKEIHHFHQKIFLRE-LEKYETMPEDVGHCFVTWASKFDMYVHYCKNKP 1381
            .||.....::      :|::.|.||:  .|| :::|    |::.:..|.:....:...|..|.:.
  Rat   755 GVPLKEKAEQ------LKDLIHLHQR--QRERIQEY----EEILYKTVQFHQVKEELTHLIKPRE 807

  Fly  1382 T-----------SNNLLVQHGGSFFEELQRRLEVDH------PLPAYLIKPVQR----------- 1418
            .           |..:|:|.|.|    ..||..|||      .|...:|..|||           
  Rat   808 LELLAQPMELEGSKEVLMQLGRS----QGRRAHVDHLHRLALSLGVDIISSVQRPNCSNISAKSL 868

  Fly  1419 -----------------ITKYQLLLKDLLSCC--EESHGEIKEGLE--------VMLNVPKKAND 1456
                             ..:|:.:|...|..|  .|...|:||..:        :..|..||...
  Rat   869 QQQLEALELDSRDWSAKAKEYEQVLACSLEYCTTREEINELKESFKDIKKKFNNLKFNYSKKNEK 933

  Fly  1457 AMHLSLL----ENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVKESNV 1517
            :.:|..|    :..:...||:               |.:||..|:          ..|::.:| |
  Rat   934 SRNLKTLQYQIQQVETYADKI---------------QALRKKMEK----------VNKKISDS-V 972

  Fly  1518 VKYQFK-------------------SKLMT---TDMGITEHIE----------GDETKFAVWTGR 1550
            :.|...                   .|::|   .::.:|||::          .|.:...|..|:
  Rat   973 LSYPSNKANTLVEAMEDLKKHVDDFDKVVTDYKMNLDLTEHLQEVIEECNFWYEDASATVVRVGK 1037

  Fly  1551 SPMLSDCR--------------------------------IVLKATSLETKQIWVKKL----REV 1579
            ..|  :|:                                :..:...||..|.:.:|:    :|:
  Rat  1038 YSM--ECQTREAVDILHRQFQKFVTPSVPQQEERIQEVVSLAQRLYGLEEGQKYAEKIVTRHKEI 1100

  Fly  1580 MQ---ETC------------------------FSGTSLTLPKSPAKHSGSSQRSSRDLDEQLTEN 1617
            ::   |.|                        |.|.|:.|.|.|.:            |||    
  Rat  1101 LESITELCGSLVELKEKLMQGDVPKVNSNLEDFHGNSIDLLKEPGR------------DEQ---- 1149

  Fly  1618 DHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYIATSGSNELSVSKG-----------QQVEIV 1671
                          ||.|:.:...|...   ||..|.:|:.|..:..|           |.:.:.
  Rat  1150 --------------TTFSEERSEGQAQG---ADVSAINGTREDGLPVGLRQSFDKEDSAQGLTLP 1197

  Fly  1672 EPPTAGEPDFCLVRLNPQHDDAAVQE-GLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQD 1735
            |...:||...|:     ..||.::.. .:.|.|.|.|                       |||: 
  Rat  1198 EDTLSGEDSECI-----SSDDISLPPLPVTPESPLAP-----------------------SDME- 1233

  Fly  1736 QSNRSKADALSSSTKRRGFSGRNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQ 1800
                                            .::|.||..|....|...:||.....       
  Rat  1234 --------------------------------VEEPASSSALALHISGYRMRTGTGGL------- 1259

  Fly  1801 NQQPGASPATVLPSSQFPSSTQHPGGAGAGDYEPDEEV---GLELP-PPMKPIQEPHLIANGPPA 1861
                |.:|.:|||          |..|....|...::.   ..|.| |..|  .||.|.:.|   
  Rat  1260 ----GKAPESVLP----------PPTAFTDGYHNKKDTFTSHFERPYPQFK--AEPLLTSRG--- 1305

  Fly  1862 FAKDAKESSGNMAS--------PGKMDGN-------PLSEIEEIVKTTTEQHESNSRV------- 1904
                    ||.|::        |.:|...       |.|:.:||...|.|:..::|.|       
  Rat  1306 --------SGEMSTKLHVNVKCPARMPREVHDKALPPSSQAQEISLGTQEKVHADSNVTKTQDRL 1362

  Fly  1905 ----DGGGGVENASTNGHGRSHD-----NNDESHTAVSDKAAALKKRQCVFAELMS 1951
                |...|:.:.|..  .|||.     ..|..:::......:|..:...|:.|:|
  Rat  1363 HAALDVSPGLSSQSDT--SRSHQRQVGPQGDRKNSSAEKSVVSLAGQAPHFSRLLS 1416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103 21/96 (22%)
SPEC 782..997 CDD:238103 54/250 (22%)
SPEC 897..1119 CDD:238103 49/240 (20%)
SPEC 1125..1226 CDD:197544 23/117 (20%)
RhoGEF 1287..1456 CDD:279015 44/248 (18%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 27/196 (14%)
PH 1495..1580 CDD:278594 20/152 (13%)
SH3_Kalirin_1 1643..1707 CDD:212786 16/75 (21%)
RhoGEF 1945..2122 CDD:279015 3/7 (43%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
Ccdc141XP_003749542.2 SPEC 132..356 CDD:238103 50/240 (21%)
SbcC <219..804 CDD:223496 119/636 (19%)
SPEC 260..458 CDD:295325 45/226 (20%)
I-set 1409..1498 CDD:254352 3/8 (38%)
Ig 1425..1499 CDD:299845
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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