DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and Plekhg4

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_038954139.1 Gene:Plekhg4 / 307796 RGDID:1310790 Length:1231 Species:Rattus norvegicus


Alignment Length:1208 Identity:257/1208 - (21%)
Similarity:428/1208 - (35%) Gaps:372/1208 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   629 LARSGEADPNEIYSV----ARELELQVGSFAERVEQRRRRL----DMAV-------IFYTHEKDV 678
            |::..||.|..:..:    ....::.||..|:::...:..|    :|.:       :.|.|:   
  Rat   283 LSQLQEASPGSVQQLLLVGKMPEDMPVGLQAKQLASHQSLLTHIPNMELPTSLGGCLSYCHQ--- 344

  Fly   679 TAWID-KLRTDVSTDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQ---EMRS 739
             ||:| ::|.:......:::...|:|:...::..::..:...|...|   .|.::|:|   |...
  Rat   345 -AWLDFRMRLETLQQSCQVACALLQGVIDSMKAMRQPLESGEVGELL---QQAQSLMQQVLESPQ 405

  Fly   740 LEYADNTGSI-----------AAL----EATLEKLNKQKVELEELWSARKFRADLILR----LRY 785
            |.:..:.||:           .||    .:.::|.::...:::||......:::..:|    |:.
  Rat   406 LSWLQSQGSLELAWLKQGMPQVALSPDYRSAVDKADELYGQVDELLHRLTLKSNQRIRALELLQA 470

  Fly   786 FERDARLLSVQMEMWSEELQHADLSRDYQKAEQLIRMHNESVTEIQNATYEVVQQGQDLLQLFEN 850
            .|....:| .|:|:|.:|:....|....:.:..::........|:.....|.|:||:.|||..  
  Rat   471 LEAQEGVL-CQIEVWLQEVGWPGLEEPGEPSLDMLLQAQGPFQELDLVAQEQVKQGEKLLQPL-- 532

  Fly   851 AGFISMADATHTAQARIEYLLDFLREREIDLEEMSEAKRAKLEQAVQLCQFQNDANQVISWIRNG 915
            .|:    :|.........:|.  ||.:.::.......:|.:|..|.:|.||...|:   :|...|
  Rat   533 VGW----EAAELGPTGKRFLA--LRSQLMEFSRALAQRRQRLADAEKLFQFFKQAS---TWTEEG 588

  Fly   916 EAMLVASFVTPNSLQEAEQLRKGHEQFQIAIEKTHTSAVQVKYRADALINANHYDPLSIDEISDD 980
            :.:|.          |.||                                              
  Rat   589 QRVLT----------ELEQ---------------------------------------------- 597

  Fly   981 VTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCDGGGGSDKAQAIVQL 1045
                                      :|.|   .||..|:..:                      
  Rat   598 --------------------------ETPE---VVLQRLQLHW---------------------- 611

  Fly  1046 ISKHQEQKEA-FLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQENQVLDYW 1109
             |||.:...| |.|...||     |.|......|:|......|:                  |.|
  Rat   612 -SKHPDLPPAHFRKMWALA-----TGLGSEGIRQECRWAWAQCQ------------------DTW 652

  Fly  1110 TLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKE 1174
            .    :|||.::..|..:|       :::|...|:.....:..|..     |.|.::..::..| 
  Rat   653 L----ALDQKREAALKPQS-------MNSTATLYVRRAPAIPTIPP-----LRKSYSFDQNLGK- 700

  Fly  1175 TRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLG 1239
                     .|.|: ..:||.        .|:|..            |.:.|...|:..:     
  Rat   701 ---------HLGDA-SNRGHC--------AATVTD------------CHRPEARGGIRPR----- 730

  Fly  1240 SDGNSSISSSSGDRHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLAT 1304
            |..:..:|.||..|                          |..|.:.::||::.|||.||..|..
  Rat   731 SSPSVPLSGSSDFR--------------------------SPNRLQLVLAEMVATEREYVRALDY 769

  Fly  1305 CIKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASK 1369
            .|:.:..|... ..||..|.||...:|||::::..||...||||||.....|..|.|.|:....:
  Rat   770 TIQNYFPELDR-SDVPQGLRGQRAHLFGNLEKLRDFHFHFFLRELEACTRHPPRVAHAFLRHRVQ 833

  Fly  1370 FDMYVHYCKNKPTSNNLLVQHGGSFFEELQRRLEVDH-PLPAYLIKPVQRITKYQLLLKDLLSCC 1433
            |.||..|.||||.|:.|:..:|.:||:|.|:.|. || .|.:||:||:||::||.|||::|...|
  Rat   834 FGMYALYSKNKPRSDALMSNYGHTFFKEKQQALG-DHLDLASYLLKPIQRMSKYALLLQELARAC 897

  Fly  1434 ---EESHGEIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGR 1495
               .:..|.::....::....:..||.:.:..::.|||::.:.|::|.||.|       .:|.|.
  Rat   898 GGPAQELGALQAAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEF-------TVRAGH 955

  Fly  1496 E---RRVFLFELYLLFAKEVK-ESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTGRSPMLSD 1556
            .   |||||||..|||:|..: .:.|..:.:|......|:|:||.....:.:|.:|..|..... 
  Rat   956 HKSCRRVFLFEELLLFSKPRRGPAGVDIFTYKRSFKMADLGLTECCGESKLRFEIWFRRRKARD- 1019

  Fly  1557 CRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDLDEQLTENDHDR 1621
             ..||:|:.:.|||.|...:                              ||.|..|...|...|
  Rat  1020 -LFVLQASDVATKQAWTADI------------------------------SRLLWRQAVHNKEVR 1053

  Fly  1622 -CSLASFGSGNTTDSDNKLGNQEATWVVA-DYIATSGSNELSVSKGQQVE-----IVEP------ 1673
             ..:||.|.||           :|.|.:| ...|.:..|...|.|.:.|.     .|.|      
  Rat  1054 MAEMASMGVGN-----------KAFWDIAPSEEAINDRNINYVLKRRDVRSRASIAVAPFDYDNP 1107

  Fly  1674 ------PTAGEPDFCLV----RLNPQHDDA--AVQEGLVPVSV-----------LKPPPGSHKHG 1715
                  ...|:...|.|    .|:...|.|  .|...|:|.:.           |...|......
  Rat  1108 YLGALASLPGDRASCSVLGSLNLHLYRDPALLGVHWSLLPPNFPEEASLDTEVDLGSQPSLTPED 1172

  Fly  1716 SGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRG 1753
            |..::...|::||..||         :..:|..|..||
  Rat  1173 SEVSSQCPSASGSSGSD---------SSCVSGQTMGRG 1201

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103 31/182 (17%)
SPEC 782..997 CDD:238103 35/218 (16%)
SPEC 897..1119 CDD:238103 32/222 (14%)
SPEC 1125..1226 CDD:197544 14/100 (14%)
RhoGEF 1287..1456 CDD:279015 63/172 (37%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 37/125 (30%)
PH 1495..1580 CDD:278594 27/88 (31%)
SH3_Kalirin_1 1643..1707 CDD:212786 20/98 (20%)
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
Plekhg4XP_038954139.1 SPEC 463..>614 CDD:413338 41/270 (15%)
RhoGEF 749..915 CDD:238091 63/167 (38%)
PH_puratrophin-1 915..1050 CDD:270062 43/173 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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