DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and zormin

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_001261317.1 Gene:zormin / 2769001 FlyBaseID:FBgn0052311 Length:3664 Species:Drosophila melanogaster


Alignment Length:1459 Identity:261/1459 - (17%)
Similarity:500/1459 - (34%) Gaps:357/1459 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   260 QQSQPSQQSR---------SVGGNPDMSAAVNKA---------------------LRQIEL---- 290
            ||||.||||:         ....:|..|.|::.|                     ||...:    
  Fly    37 QQSQQSQQSQLDAFNYSATMSSSSPTPSQAMSTAMSTGTGTGTGTTHTTPPSSSSLRATTIGTVV 101

  Fly   291 IHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEKMFDWILHNRDVFQMSYVEIGHNYSVAKSLQD 355
            :..|..:|::                ...|..||::..::.    .:.....:|.|...:..:|.
  Fly   102 VRCGPIQLVI----------------ALLQSPEKIYIKVVE----LEPKITALGENLDESLRMQR 146

  Fly   356 EHQKFAVASMNVSVNIDRILAVAARLIESQHYAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLS 420
            ||.:......::...:|..:..|.:|:.|:..:::.:..:|..|:..|:|....|.:|..:|.|.
  Fly   147 EHDETLRNLQSLPGPMDEFVQKADKLLASKRISSELVNAMADTLNIIWQDILNLLQDRQHLLILC 211

  Fly   421 VLFHHKAEQYCNSVASWAAACQASQPLPSDIQSLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQ 485
            ..||.|..|....:.....||:.:.. |.|:..::..:...:.|...|............:||.|
  Fly   212 TQFHDKMTQCFRKMDQLELACEETLH-PPDVPRVQEFLNRFKQLRIDMLTGVMAALKDGNELLAQ 275

  Fly   486 LDHLVQVCNQPPPPGVPDHRKNSNNGSFNKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKW 550
            |:.|.::......   |:|.|.                |.:.....|...:..:.....:||..|
  Fly   276 LEELEKLETLDTR---PEHIKR----------------DATRAVHQVQQWLEALHDRRNSLELAW 321

  Fly   551 HQERLRLHQTLALRLFQEDVKQVLDWLKNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQNT 615
            ...::::.|.|||.|...::.. |:.......:.|.....:|...|.|....|.:..::..|...
  Fly   322 QTRKIQMEQCLALALLGRELVD-LEAALQQARMELNTMYSLGECEHTANEMLTKYREWKQQALLL 385

  Fly   616 YSNAQKLLAAADELARSGEADPNEIYSVARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTA 680
            ...|.|:..|.:::..:|.                   |.|.        |.....|......|.
  Fly   386 RDRALKITRAKEKVQSAGH-------------------FTEE--------DACARAYAVLSGCTE 423

  Fly   681 WIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQEMRSLEYADN 745
            .:|.:                            ||:|             ..|.|.......|::
  Fly   424 HLDLV----------------------------DQRE-------------HWLHQSREFFAKAEH 447

  Fly   746 TGSIAALEATLEKLNKQKVELEELWSARKFRADLILRLRYFERDARLLSVQMEMWSEELQHADLS 810
            |.|:      ||||     |||                        |.||::...|.|       
  Fly   448 TVSV------LEKL-----ELE------------------------LTSVKLPPHSPE------- 470

  Fly   811 RDYQKAEQLIRMHNESVTEIQNATYEVVQQGQDLLQLFENAGFISMADATHTAQARIEYLLDFLR 875
             .|....::.|       :::|.|.|.::.|.         |.:.....|......::.:||.|.
  Fly   471 -SYAMFSKVDR-------DVRNFTEEPLRLGY---------GILDEVGRTQPETQGVKRVLDELE 518

  Fly   876 EREIDLEEMSEAKRAKLEQAVQ--LCQFQNDANQVISWIR-NGEAMLVASFVTPNSLQEAEQ-LR 936
            .|::.::.:. |..::.:|.||  |.:|.|..|::::|:| :|:..|..|.....:||:|:| |.
  Fly   519 NRKVYIQGIC-ANSSEDQQKVQRALSEFLNHHNELLAWLRASGQHQLQQSVDMGGNLQQAKQFLL 582

  Fly   937 KGHEQFQ---IAIEKTHTSAVQVKYRADALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKL 998
            :.||..|   |..|..:.....:|...::|.....||   :|..::.:.|.|.:|.....:|...
  Fly   583 QHHELMQDLEIKGELINLLLESIKVHLESLSPQERYD---VDSKAESLHKHWIELKDLVLKRVDY 644

  Fly   999 VTASINFYKTAEQVCSVLDSLEREYKREDD----------WCDGGGGSDKAQAIVQLISKHQ--- 1050
            |:..|:|::.|.::.|.||:|:|:.::..|          |      :..|....:|.|:.|   
  Fly   645 VSLLIDFFELANELSSQLDNLQRQLQQTPDEHKLQFLQATW------TGIASTFGELKSRGQRFI 703

  Fly  1051 --EQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSK------LDKLLTQENQVLD 1107
              :..:.:|:..:.|:...||...::.|.........|....:..|      |:|:::...:.:.
  Fly   704 NLKIVDPYLETKSSAQAVQETLNDFSKRQVDVTSSLENWTTSIAEKREVEYLLEKVMSDNEETVA 768

  Fly  1108 ---------YWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLK 1163
                     |.....:|:|..|..:.........|:.|....:.........:||..::...|.|
  Fly   769 KSTQVDTQLYPVFTSQSVDSKQLLISTREKLTNVIQDIERAQDEIQQRIQTTLGIQTKDQPSLAK 833

  Fly  1164 EH---NEFRS-TAK------ETRERVKLLIQLADSLV----EKGHAHASDIKQWVASVDQRYKDF 1214
            ..   |..|. .||      :.|..|:.:||..:::|    |.....|...|:..:..|:...:.
  Fly   834 IEQVINNLRMLKAKLDGIKYDYRTLVESVIQFLENIVQLRREIDDYFARQQKEPASGADRSIAEH 898

  Fly  1215 SNRMDSYCEQLEKSLGMSQ--------------------------QQLLLGSDGNSSISSSSGDR 1253
            ....|...::....:..|:                          :.|.|..:.|||...|:.:|
  Fly   899 EKFRDQCMDKFRSLITQSELLIDRVRVLEPPGAREIDTDRILKLLENLRLHFESNSSARMSTLER 963

  Fly  1254 -------HSD-PTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFL 1310
                   .|| ..::..|:|.:::..|||.:...|....:.........||.....:...:|...
  Fly   964 LEKIEQFRSDLEDIDRSLDSVSQQLHEINNQSVDSLAAAKTTSLAFEYFERTIECSMPRQLKSTR 1028

  Fly  1311 EEFRAGKSVPSALIGQEDVIFGNIKEIHHF----HQKIFLRELEKYETMPEDVGHCFVTWASKFD 1371
            .:.|.|::..:..:.:        |.|..|    .|::|:...|....:.:::......|.|..|
  Fly  1029 HQRRWGQTAHTIELLE--------KRIEKFTESTSQQLFITNPESERYVKDELRKLNEKWQSFKD 1085

  Fly  1372 MYVHYCKNKPTSNNLLVQHGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQL-------LLKDL 1429
            .    .|.|..|.|    ....|||.:: :::.::...:|....|.....|..       |:.|:
  Fly  1086 Q----VKQKRKSLN----QATDFFEVVE-KIDAEYREISYFYTSVSNKVPYLRDSVEAGNLVNDI 1141

  Fly  1430 LSCCEESHGEIKEGLEV-------MLNVPKKANDAMHL--SLLE-NCDVSVDKLGEVVLQDAFQA 1484
            .:........::..|:.       |..|....||.|::  |.:: ..|::|  :.|.:.|:..|.
  Fly  1142 ENYVTSREAALRSKLDSASQCAHDMNKVSSLYNDVMNIFQSFIKLKMDINV--VQERLKQEQRQK 1204

  Fly  1485 WDTKQIIRKGRERRVFLFELYLLFAKEVKESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTG 1549
            ...::..|...||.           |.:||:     :.|.:|...:.   ..:|....:.|:...
  Fly  1205 EQRERDARDQAERE-----------KAIKEA-----EAKERLHREEQ---SRLENQRQQAAIEQA 1250

  Fly  1550 RSPMLSDCRIVLKATSLETKQIWVKKLRE 1578
            :.. |:...:.|:..::..::..::.:||
  Fly  1251 QRE-LAARELALREQAVREEEARLQAIRE 1278

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103 29/153 (19%)
SPEC 563..778 CDD:238103 34/214 (16%)
SPEC 782..997 CDD:238103 49/221 (22%)
SPEC 897..1119 CDD:238103 56/258 (22%)
SPEC 1125..1226 CDD:197544 20/114 (18%)
RhoGEF 1287..1456 CDD:279015 29/186 (16%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 19/118 (16%)
PH 1495..1580 CDD:278594 13/84 (15%)
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
zorminNP_001261317.1 SPEC 126..332 CDD:238103 41/229 (18%)
SPEC <504..641 CDD:295325 35/140 (25%)
COG1340 960..1298 CDD:224259 61/358 (17%)
RILP-like <1190..1315 CDD:304877 18/111 (16%)
MAP7 1233..1365 CDD:283355 6/50 (12%)
I-set 1390..1479 CDD:254352
IGc2 1403..1469 CDD:197706
I-set 1491..1580 CDD:254352
IGc2 1504..1570 CDD:197706
I-set 1589..1675 CDD:254352
Ig 1605..1675 CDD:299845
I-set 1702..1786 CDD:254352
Ig 1713..1786 CDD:299845
I-set 1811..1902 CDD:254352
Ig 1828..1892 CDD:143165
I-set 1927..2015 CDD:254352
IGc2 1940..2005 CDD:197706
I-set 2142..2231 CDD:254352
Ig 2158..2231 CDD:299845
I-set 2238..2325 CDD:254352
Ig 2254..2324 CDD:299845
I-set 3566..3655 CDD:254352
Ig 3583..3650 CDD:143165
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4240
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.810

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