DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and Pura

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_996016.2 Gene:Pura / 2768948 FlyBaseID:FBgn0035802 Length:1904 Species:Drosophila melanogaster


Alignment Length:1974 Identity:402/1974 - (20%)
Similarity:684/1974 - (34%) Gaps:650/1974 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 TILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKYK-----FETTTVSIES--LNKIVE--- 140
            |:.:::..|.| :|:.|       :|.:.||.:.....:     |:.:.|..|.  |.|..:   
  Fly   322 TLARLIDSHLS-HIYPV-------YWARTRAILIQQARERLVCGFDGSLVRFEQRFLCKFAQIAA 378

  Fly   141 ----SHQLTGDFEGQQLYDHQQW-------------TDARLA----IEDFFWQAGDMADRIDDLQ 184
                :||:     |:....|..|             :||.:|    ..:.:     :..:::..:
  Fly   379 TLRTAHQI-----GESWLWHPGWPLATSNGALVLQLSDAEIAHALRPSELY-----LCIKLESTE 433

  Fly   185 EDLN---------RNDFAEDVPLARHAIDHHNEMRKKITKLPIEDLDMQGKKLLAKINAMAPPGG 240
            .|.:         |:...|: .:..|.|||.|.     .:||:..|.::.....|.:.|      
  Fly   434 SDADCKPRLYAVWRSSRKEE-SVQSHCIDHENP-----GELPLSVLQLEMSTAAAALMA------ 486

  Fly   241 QAPTNSGGPDMDSGPSSAGQQSQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHK 305
                           |..|:..|..|         ::..:|.:::.::.|     .:|.|...|.
  Fly   487 ---------------SDCGELPQLLQ---------NLLVSVERSIERVSL-----NELQMPMHHD 522

  Fly   306 KVK--LDQ-----CFQWRLFEQDCE-KMFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAV 362
            :.:  ||:     |....|....|. :..|.|..|: :|...|:     .....:.||.....:.
  Fly   523 RGEDSLDEANNNGCNNNLLGSPKCALRRSDLITKNK-LFNSRYM-----LRRLTNRQDSMNSTSS 581

  Fly   363 ASMNVSVNIDRILAVAARLIESQHYAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKA 427
            .:.|||   ||..:.::   .|...|.:.:.|                            .|.:|
  Fly   582 GNSNVS---DRSSSSSS---SSSSSAGEELLT----------------------------SHSEA 612

  Fly   428 EQYCNSVASWAAACQASQPLP--------SDIQSLETAIRT-----HQSLYEAMCQAYTEVHSTS 479
            :...|||.:.|:....|..||        ..|.|.|.|..:     |.||  ..|:  ||:..:|
  Fly   613 KMRSNSVGNEASGASTSPALPLYCLGNSFPHIDSDEEASDSIGPGKHHSL--ETCE--TELLPSS 673

  Fly   480 ------KKLL-----------YQLDHLVQV---CNQPPPPGVPDHRKNSNNGSFNKYERQNPAAD 524
                  :|||           .|.|.||.|   |              ..:...|.||.......
  Fly   674 SIAELPEKLLTSGVYLPGTRTLQGDPLVTVDAAC--------------VASAGINCYEMATLLLY 724

  Fly   525 YS---EGASHVLAV-----IHQILSHHRTLEAKWHQERLRLHQ---------TLALRLFQEDVKQ 572
            ||   |.:|.....     ....::.|::.|.:..|::.:..|         |:.:.:.:.....
  Fly   725 YSTIPERSSCPFTTPATPGTTATINGHKSTEQQQQQQQQQQQQKQQPAQQTFTILIAIEKSQHLC 789

  Fly   573 VLDWLKNHGEVFLRKNTG-----------------IGRNFHKARVYQTSHDN------------- 607
            |:|.:.....: |.|..|                 .|:...|.:..|..::|             
  Fly   790 VIDLICQSLRL-LAKQIGNCEILAVCPDSSLLQLCNGQQQQKLQQQQQQNNNSDHPEPSSPSPVD 853

  Fly   608 ---FENVAQNTYSNAQK-----LLAAADELAR-SGEADPNEIYSVARELELQVGSFAERVEQRRR 663
               |.:|.|.|.|.|..     ||.:...|:. .|.:..:...:..||...|:.:|..:......
  Fly   854 LVKFISVDQVTTSVAPSQLPAGLLPSVPALSTLPGISQRHHDATKWREFFAQLEAFQRQCSTAGG 918

  Fly   664 RLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTIS 728
            ||            |:|..:....|:....||   ..|.|..|.|.:...|.|..|    |..:.
  Fly   919 RL------------VSALSEIRAADLQGLPTR---RQLYGQHRALSRALMDSQLHS----LRKMG 964

  Fly   729 QGE-ALLQEM-RSLEYA---------------DNTGSIAALEAT---------LEKLNKQKVELE 767
            .|: |.||:: |::..|               .::|:...::|.         ..::::....||
  Fly   965 AGQLARLQDLARAITSAPGSPRMTSQPQSSSSSSSGAFLNVDAACKLRKVTLLFNEVDRAAQRLE 1029

  Fly   768 ELWSARKFRADLILRLRYFERDARLLSVQMEMWSEELQHADLSRDYQKAEQLIRMHNESVTEIQN 832
            :|...|:.|...:.|.|..|.:..    ::..|    ..:|.:.:.||..|| ...|||....|.
  Fly  1030 QLTEQRRERLRQLTRQRALEDEIS----EVTSW----MGSDGAENLQKFSQL-HWDNESQLRTQE 1085

  Fly   833 ATYEVVQQGQDLLQLFENAGFISMADATHTAQARIEYLLDFLREREIDLEEMSEAK---RAKLEQ 894
                         |.||...||:|   .|.|:.|      .|....:.:..:||:.   ::.|:|
  Fly  1086 -------------QEFEKYYFIAM---KHLAKGR------DLHAAALKVSVLSESANNLKSALDQ 1128

  Fly   895 AVQLCQFQNDANQVISWIRNGEAMLVASFVTPNSLQEA--EQLRKGHEQFQI---------AIEK 948
            ..|..:..::        |...|..:...:|.:..:.|  |:|::..||...         .:.|
  Fly  1129 FAQKLELAHE--------RYDAAGRLLHLLTQHQRENAAREELQRLAEQLGATSLLEKHWPVMRK 1185

  Fly   949 THTSAV-----------QVKYRADALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTAS 1002
            |||..|           :|.||..:...::.....|....|           .:.|.|:      
  Fly  1186 THTLPVASSTPAAAAGKRVSYRCSSASRSSFEGGPSSSNCS-----------CWRESRN------ 1233

  Fly  1003 INFYKTAEQVCSVLDSLEREYKREDDWCDGGGGSDKAQAIVQLISKHQEQKEAFLKACTLARRTA 1067
                      ...:|.:|.|.:.:|..||||.|.::...|.          ::.|..|       
  Fly  1234 ----------LEDMDQMEEEEEEQDHDCDGGDGEEQQSKIA----------DSGLGVC------- 1271

  Fly  1068 ETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQA 1132
                             .|||.:  .||.::.:.:       :|.:||.|:..:...|:|.:|:.
  Fly  1272 -----------------DNCERN--PKLARICSCQ-------SLNEKSHDELLEDECFDRPSKRY 1310

  Fly  1133 IEWIHNTGE--AYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHA 1195
            ::.:|:..|  |:|....:.:.:.|.|.                                     
  Fly  1311 MDIMHSPMEANAHLQCHGSSLELPKLEE------------------------------------- 1338

  Fly  1196 HASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTLE 1260
                    ::.:|.:.                     |:.|||                      
  Fly  1339 --------LSCLDPKI---------------------QKTLLL---------------------- 1352

  Fly  1261 AKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIG 1325
                                      ||.|::.|||.||..|...|:.:::|. ..:.:|..|.|
  Fly  1353 --------------------------IMREMIGTERDYVRSLYYVIENYIDEL-LREDIPQPLRG 1390

  Fly  1326 QEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQH 1390
            |.:||||||::|..||...||.|||:||..|..||..|:...|||.:|..|.||||.|:.||.::
  Fly  1391 QRNVIFGNIEKIFEFHNSHFLGELERYERNPLKVGAAFLEMESKFYLYALYNKNKPKSDTLLSEY 1455

  Fly  1391 GGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEESHG-----------EIKEGL 1444
            |.|||:..|.:|:....|.:||:|||||:.||.|||:.|:..|:...|           |::...
  Fly  1456 GSSFFKPKQMQLQDKLDLASYLLKPVQRMGKYALLLQQLVKACKGVEGAALQEIAADVEELQRAE 1520

  Fly  1445 EVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRE--RRVFLFELYLL 1507
            |::....:..||.:.:..|.:|||:|.:.|.::.|:.|..|..    |.|::  |:|||||..:|
  Fly  1521 EMVKFQLRHGNDLLAMDSLRDCDVNVKEQGRLLRQNEFLVWQG----RGGKKTLRQVFLFEELVL 1581

  Fly  1508 FAKEVK---ESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVW-TGRSPMLSDCRIVLKATSLET 1568
            |:|..:   ..|:..|.:|:.:.|:|:|:|.|.....|||.:| ..|.|   |...:|:..|.:.
  Fly  1582 FSKARRFPDHKNLDIYIYKNSIKTSDIGLTAHTGDSATKFEIWFRKRKP---DDTWMLQCMSEDI 1643

  Fly  1569 KQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGS----------SQRSSRDLD-EQLTEND---H 1619
            |..|.:::.:::.:.......:.|.:..:...||          :|.|.|.:. .||.:..   |
  Fly  1644 KNAWTEEISKLLWKQAKRNREVRLAEMSSMGIGSKPCLDIRPSNNQISDRSIPLAQLNKTPKLRH 1708

  Fly  1620 DRCSLASFGSGNTTDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLV 1684
            ......|....|:..|::.|.:..:|        ||||   |:|.|.        ::|       
  Fly  1709 SEPGKGSMRRPNSLISESSLSSGTST--------TSGS---SISGGS--------SSG------- 1747

  Fly  1685 RLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSST 1749
                 |:|..               |.|....|....|.|::.:..|...:..|.::|..|:.|.
  Fly  1748 -----HNDGG---------------GRHSLHFGKLPGAHSASSTNCSATLELINETQALKLAKSP 1792

  Fly  1750 KRRGFSGRNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQPG-ASPATVLP 1813
            ...|..|.:  ...:...|....:......:.|::|    .|.:..:..|.:.:.| .|...|.|
  Fly  1793 SGGGIKGAD--TAADGGNTSGNGNGNGNAFRSSKRN----HKRSTTIVSQLSMESGIVSDMCVTP 1851

  Fly  1814 --------SSQFPSSTQHPGGAGA 1829
                    ||:...||...|.:||
  Fly  1852 DQEQSAAESSRSSWSTSTTGASGA 1875

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706 16/79 (20%)
SPEC 314..>468 CDD:238103 33/167 (20%)
SPEC 563..778 CDD:238103 51/279 (18%)
SPEC 782..997 CDD:238103 48/239 (20%)
SPEC 897..1119 CDD:238103 42/243 (17%)
SPEC 1125..1226 CDD:197544 10/102 (10%)
RhoGEF 1287..1456 CDD:279015 71/179 (40%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 39/127 (31%)
PH 1495..1580 CDD:278594 28/90 (31%)
SH3_Kalirin_1 1643..1707 CDD:212786 11/63 (17%)
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
PuraNP_996016.2 PX_domain 15..>52 CDD:295365
RhoGEF 1353..1532 CDD:279015 71/179 (40%)
PH_puratrophin-1 1524..1663 CDD:270062 41/145 (28%)
PH 1562..1655 CDD:278594 30/99 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45462262
Domainoid 1 1.000 62 1.000 Domainoid score I2478
eggNOG 1 0.900 - - E1_KOG0689
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.740

Return to query results.
Submit another query.