DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and ARHGEF16

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_016856538.1 Gene:ARHGEF16 / 27237 HGNCID:15515 Length:726 Species:Homo sapiens


Alignment Length:816 Identity:158/816 - (19%)
Similarity:287/816 - (35%) Gaps:294/816 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1586 SGTSLTLPKSPA-KHSGSSQRSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVA 1649
            :|:....|.|.| :||.||      |:|:|.              |:...|:.:|          
Human     8 AGSRTPQPPSMAQRHSDSS------LEEKLL--------------GHRFHSELRL---------- 42

  Fly  1650 DYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQ-HDDAAVQEGLVPVSVLKPPPGSHK 1713
                .:|.|               |.:|.|   :||.:|: .||||.|. .||......|||..:
Human    43 ----DAGGN---------------PASGLP---MVRGSPRVRDDAAFQP-QVPAPPQPRPPGHEE 84

  Fly  1714 HGS---GTAANAASSAGSQKSDMQDQSNRSKAD-----------ALSSSTKRR------------ 1752
            ...   .|.:.||...|:|:...:..:..|||.           .||....||            
Human    85 PWPIVLSTESPAALKLGTQQLIPKSLAVASKAKTPARHQSFGAAVLSREAARRDPKLLPAPSFSL 149

  Fly  1753 ----------GFSGRNWLPLMNR------KGTDKP----------PSSKPLVKKPSEKNLRTPQK 1791
                      |...||   |.|:      ||..||          |..:.|.::||:.:.|:|.|
Human   150 DDMDVDKDPGGMLRRN---LRNQSYRAAMKGLGKPGGQGDAIQLSPKLQALAEEPSQPHTRSPAK 211

  Fly  1792 HAEELAEQQNQQPGASPATVLPSSQFPSSTQHPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIA 1856
            :.:.|..::..:                          |.::.|       |...:.|||..|  
Human   212 NKKTLGRKRGHK--------------------------GSFKDD-------PQLYQEIQERGL-- 241

  Fly  1857 NGPPAFAKDAKESSGNMASPGKMDGNPL-----------SEIEEIVKTTTEQHESNSRVDGGGGV 1910
            |.......|..:.|.:.....|:|...:           |::.|:|:.              |.:
Human   242 NTSQESDDDILDESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVEL--------------GIL 292

  Fly  1911 ENASTNGHGRSHDNNDESHTAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTN 1975
            :..||..                      :|||....|::::|.:|...|..:|..::       
Human   293 DQLSTEE----------------------RKRQEAMFEILTSEFSYQHSLSILVEEFL------- 328

  Fly  1976 SDIPMPEDLKGGKMKL----VFNNIKDIYEWHRDFF--LRALRNCQKSPADLGPLIKRSATK-FA 2033
                ..::|:....::    :|:||.|:....:.||  |......|....|:..:::..|.| |.
Human   329 ----QSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLVEDISDILEEHAEKHFH 389

  Fly  2034 LYYTYCSNKPLS----EYIVSAHYQYFDSIRQKLGHR-----LDLSNLIIKPVQRITKYELLIKE 2089
            .|..||||:...    :.::|::..:.:::|: :..|     |.:.:.:|.|:||:|:..||:..
Human   390 PYIAYCSNEVYQQRTLQKLISSNAAFREALRE-IERRPACGGLPMLSFLILPMQRVTRLPLLMDT 453

  Fly  2090 IIKATEG-AGLYKEVPMLQEAYQQMKVVVKTVN------------DMMVVLRSLQDFDGE----- 2136
            :...|:| :..||      .|.:.:|.:.|.|.            :.|..|.:..||...     
Human   454 LCLKTQGHSERYK------AASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPL 512

  Fly  2137 ITAQGSLLMQGPMNCVVDAAQKHREL------QVFLFQQIIIFADIEKTKNQYASPIFKYRSHIQ 2195
            |:|...||.:|.: .:|:.....|::      .:|||..:::... :|::..|....:...:|||
Human   513 ISASRWLLKRGEL-FLVEETGLFRKIASRPTCYLFLFNDVLVVTK-KKSEESYMVQDYAQMNHIQ 575

  Fly  2196 LNHMQMKEL----GDCR-------FQI---RSTDPKIPEMTIICQAASQ---------ENYAGWR 2237
            :..::..||    |..|       ||:   |:::.:..::.:...:||.         .:...|:
Human   576 VEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARWIVALTHSERQWQ 640

  Fly  2238 DMLNK-------------------ILQQQNDLIFML 2254
            .:.:|                   :..||.|::.:|
Human   641 GLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLVL 676

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1456 CDD:279015
PH1_Kalirin_Trio_like 1462..1584 CDD:270060
PH 1495..1580 CDD:278594
SH3_Kalirin_1 1643..1707 CDD:212786 15/64 (23%)
RhoGEF 1945..2122 CDD:279015 42/205 (20%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 32/178 (18%)
ARHGEF16XP_016856538.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3601
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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