DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and Arhgef40

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_006519104.1 Gene:Arhgef40 / 268739 MGIID:2685515 Length:1524 Species:Mus musculus


Alignment Length:1183 Identity:244/1183 - (20%)
Similarity:423/1183 - (35%) Gaps:346/1183 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   692 DETRLSQENLEGIERILQQYQR-DQQESSVNV-------------CLTTISQ----GE-ALLQEM 737
            :|:..|||.|....|.|....| |.|...:.:             .|..:||    || .|:|.:
Mouse   557 EESSPSQETLSTALRYLHSLLRPDLQLLGLTILLDLRKAPPLPPALLPALSQLQDSGEPPLIQRL 621

  Fly   738 RSLEYADNTGSIAALEATLEKLNKQKVELEELWSARKFRADLILRLRYFERDARLLSVQMEMWSE 802
            ..|.:.|....:...:..            ||.|               |:|.:.::.     .|
Mouse   622 VILIHEDPPAELCGFQGA------------ELLS---------------EKDLKRVAK-----PE 654

  Fly   803 ELQ-----HADLSRD-----YQKAEQLIRMHNESVTEIQNATYEV-------------------- 837
            |||     |.|||.:     :|:..:|..:....:|.::.|..|:                    
Mouse   655 ELQWDLGGHRDLSPNHWAEIHQEVARLCTLCQGVLTSVRQAIEELEGTAEPKEEEAVGMPEPLQK 719

  Fly   838 VQQGQDLLQLFENAGFISM-ADATHTAQ------ARIEYLLDFLREREIDLEEMSEAKRAKLEQA 895
            |.....|..|..|.|.|.| ..:.|:::      |.:...:|   |....|..:|..:..:.|:.
Mouse   720 VLADPRLTALQRNGGAILMRLRSAHSSKLEGPGPAELYQEVD---EAIHQLVRLSNLRVQQQEER 781

  Fly   896 VQLCQFQNDANQVISWIRN-GEAMLVASFVTP-NSLQEAEQLRKGHEQFQIAIEKTHTSAVQVKY 958
            .:|.|.|    ||:.|:.. ||..| |||..| |||...::.......|...::           
Mouse   782 QRLRQVQ----QVLQWLSGPGEEQL-ASFSMPGNSLSVLQETELRFRAFSTEVQ----------- 830

  Fly   959 RADALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLEREY 1023
              :.|:.|.  :.|:::|   |:|.  |:::...|:|  |..|....::...        |:|.:
Mouse   831 --ERLVQAR--EALALEE---DLTS--QKVLDIFEQR--LEQAESGLHRALR--------LQRFF 876

  Fly  1024 KREDDWCD------GGGGSDKAQAIVQLISKHQEQKEAFLKACTLARR---TAETF-----LKYA 1074
            ::..:|.|      .|.||.               :||.|.|..|.|.   :|.||     |...
Mouse   877 QQAHEWVDEGSARLAGAGSG---------------REALLAALALRRAPEPSAGTFQEMRALALD 926

  Fly  1075 NRSQQCYQYKGNCEGHVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNT 1139
            ..|....:..|.|....:....::..|..:.....:.|::..|..        |:..|....|:.
Mouse   927 LGSPAALREWGRCRARCQELERRIQQQLGEEASPRSHRRRRADSA--------SSAGAQHGAHSP 983

  Fly  1140 GEAYLS-------------SRSNLVGISKE-ETEGLLKEHNEFRSTAKETRERVKLLIQLADSLV 1190
            ..:..|             |..:|....:: |.|||        ..|.||..|....:     |:
Mouse   984 SPSLSSLLLPSSPGPRAAPSHCSLTPCGEDYEEEGL--------ELAPETDGRPPRAV-----LI 1035

  Fly  1191 EKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLL----GSDGNSSISSSSG 1251
            ......::::                 :|..|.        .::.:||    |.||...|.:   
Mouse  1036 RGLEVTSTEV-----------------VDRTCS--------PREHVLLGRAGGPDGPWGIGT--- 1072

  Fly  1252 DRHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVN-----------DLATC 1305
                 |.:|.|        :.|:.::|        :::||:..|:.||.           :|...
Mouse  1073 -----PRMERK--------RSISAQQR--------LVSELIACEQEYVTTLNEPVPLPGPELTPE 1116

  Fly  1306 IKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKF 1370
            ::|   .:.|..||.              :.:..||...||:||:.....|..:|.||:....:|
Mouse  1117 LRC---TWAAALSVR--------------ERLRSFHGTHFLQELQGCAAHPLRIGACFLRHGDQF 1164

  Fly  1371 DMYVHYCKNKPTSNNLLVQHGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEE 1435
            ::|..:.|::....:.|    .:....::..:|....||..|.:|::::.:|..||::||   .|
Mouse  1165 NLYAQFVKHRHKLESGL----AALTPSVKGSMESSPCLPRALQQPLEQLARYGQLLEELL---RE 1222

  Fly  1436 SHGE-------IKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRK 1493
            :..|       ::..::::.....:..|.:.:..:..|::.:.:.|:::.:|.|    |....||
Mouse  1223 AGPELSSERQALRAAVQLLQEQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPF----TVICGRK 1283

  Fly  1494 GRERRVFLFELYLLFAK-EVKESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTGRSPMLSDC 1557
            ...|.|||||..|||:| :..|.....:.:|....|.|||:||:|......|.:|..|.....  
Mouse  1284 KCLRHVFLFEDLLLFSKLKGSEGGSETFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRARE-- 1346

  Fly  1558 RIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDLDEQLTENDHDRC 1622
            ...|:|||.|||..|...:.:::..             .|.|       :::|..|         
Mouse  1347 AYTLQATSPETKLKWTSSIAQLLWR-------------QAAH-------NKELRVQ--------- 1382

  Fly  1623 SLASFGSGNTTDSDNK-LGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPTAG-EPDFCLV- 1684
            .:.|.|.||....|.| ||.:..:.::....|.:.:: ::||   ..|...|...| .|..|.: 
Mouse  1383 QMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRAS-VAVS---SFEHAGPSLPGLSPGACSLP 1443

  Fly  1685 -RLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKS-DMQDQSNRSKADALSS 1747
             |:..:..|..|::    :|:......|    ||..     |.|.:.| .:|..|..|...||:|
Mouse  1444 ARVEEEAWDLDVKQ----ISLASETLDS----SGDV-----SPGPRNSPSLQPPSPGSSTPALTS 1495

  Fly  1748 STKRRGFSGRNWL 1760
            . ...|.|.:.||
Mouse  1496 G-GILGLSRQAWL 1507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103 22/104 (21%)
SPEC 782..997 CDD:238103 55/253 (22%)
SPEC 897..1119 CDD:238103 51/237 (22%)
SPEC 1125..1226 CDD:197544 17/114 (15%)
RhoGEF 1287..1456 CDD:279015 36/186 (19%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 37/122 (30%)
PH 1495..1580 CDD:278594 30/85 (35%)
SH3_Kalirin_1 1643..1707 CDD:212786 12/66 (18%)
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
Arhgef40XP_006519104.1 RecN <755..>874 CDD:223571 34/156 (22%)
RhoGEF 1084..1243 CDD:383033 37/190 (19%)
PH_puratrophin-1 1242..1377 CDD:270062 40/160 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.