DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and TIAM2

DIOPT Version :10

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_036586.3 Gene:TIAM2 / 26230 HGNCID:11806 Length:1701 Species:Homo sapiens


Alignment Length:1905 Identity:361/1905 - (18%)
Similarity:595/1905 - (31%) Gaps:802/1905 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   106 KPDNFWQKQRASISSHK--YKFETTTVSIESLNKIVESHQLTGDFEGQQLYDHQQWTDARLAIED 168
            ||.|    |.:|:||.:  ||    ..::.||:.           .|.:|.|....|.|.|:   
Human   288 KPFN----QSSSLSSLRELYK----DANLGSLSP-----------SGIRLSDEYMGTHASLS--- 330

  Fly   169 FFWQAGDMADRIDDLQEDLNRNDFAEDVPLARHAIDHHNEMRKKITKLP-------IEDLDMQGK 226
                               ||..||.|:.:... :.|.:.::.....||       :||   ..|
Human   331 -------------------NRVSFASDIDVPSR-VAHGDPIQYSSFTLPCRKPKAFVED---TAK 372

  Fly   227 K--LLAKINAMAPPGG---------QAPTNSGGPD-MDS----------GPSSAGQ--------- 260
            |  |.|::..::...|         |.|.:..|.| .||          |.|.|..         
Human   373 KDSLKARMRRISDWTGSLSRKKRKLQEPRSKEGSDYFDSRSDGLNTDVQGSSQASAFLWSGGSTQ 437

  Fly   261 -QSQPSQQSRSVGGNPDMSAAVNKALRQIELIHT--------------GQEKLLMLWQHKKVKLD 310
             .||.|:.:.::|.:|.........:|::|:..|              ..|.|..|.|     ||
Human   438 ILSQRSESTHAIGSDPLRQNIYENFMRELEMSRTNTENIETSTETAESSSESLSSLEQ-----LD 497

  Fly   311 QCFQWRLFEQDCEKMFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRIL 375
            ..|:   .||...:...|:..                   |.|             |:|..:|.|
Human   498 LLFE---KEQGVVRKAGWLFF-------------------KPL-------------VTVQKERKL 527

  Fly   376 AVAARLIESQHYAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQY-CNSVASWAA 439
            .:.||                    |.||.:...|...|      :||:   |.| .||:.    
Human   528 ELVAR--------------------RKWKQYWVTLKGCT------LLFY---ETYGKNSMD---- 559

  Fly   440 ACQASQPLPSDIQSLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDH 504
              |:|.|                     .|..:.|            |.:||        .||:|
Human   560 --QSSAP---------------------RCALFAE------------DSIVQ--------SVPEH 581

  Fly   505 RKNSN----NGSF-NKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKWH--QERLRLHQTLA 562
            .|..|    :.|| :.|..|  |...::..:.|.|| |...:   :|.||.|  ::.|||.:...
Human   582 PKKENVFCLSNSFGDVYLFQ--ATSQTDLENWVTAV-HSACA---SLFAKKHGKEDTLRLLKNQT 640

  Fly   563 LRLFQE-------------------DVK-------QVLDWLKN----HGEVFLRKNTGIGRNFHK 597
            ..|.|:                   |.|       |:..|.:|    |.::|            :
Human   641 KNLLQKIDMDSKMKKMAELQLSVVSDPKNRKAIENQIQQWEQNLEKFHMDLF------------R 693

  Fly   598 ARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGEADPNEIYSVARELELQVGSFAERVEQRR 662
            .|.|..|....|      ..|.:.|||||..        |::: ::.|...|.|.||...|    
Human   694 MRCYLASLQGGE------LPNPKSLLAAASR--------PSKL-ALGRLGILSVSSFHALV---- 739

  Fly   663 RRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTI 727
                                      .|.|::.|.       :|.|...||.:.:..:       
Human   740 --------------------------CSRDDSALR-------KRTLSLTQRGRNKKGI------- 764

  Fly   728 SQGEALLQEMRSLEYADNTGSIAALEATLEKLNKQK----VELEEL----------------WSA 772
                     ..||:..|          ||.:..|:|    .:::||                |..
Human   765 ---------FSSLKGLD----------TLARKGKEKRPSITQVDELLHIYGSTVDGVPRDNAWEI 810

  Fly   773 RKF-----RADLILRLRYFERDARLLSVQMEMWSEELQHADLSRDYQKAEQLIRMHNESVTEIQN 832
            :.:     ...:.:.::...|...:|::..:|...|..|..|        ||.::.:::|.....
Human   811 QTYVHFQDNHGVTVGIKPEHRVEDILTLACKMRQLEPSHYGL--------QLRKLVDDNVEYCIP 867

  Fly   833 ATYEVVQQGQDLLQLFENAGFISMADATHTAQARIEYLLDFLREREIDLEEMSEAKRAKLEQAVQ 897
            |.||.:||     |:::                            ||::..:: ....:|.:...
Human   868 APYEYMQQ-----QVYD----------------------------EIEVFPLN-VYDVQLTKTGS 898

  Fly   898 LCQF------QNDANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIEKTHTSAVQV 956
            :|.|      |.|..|.:|       .:..|.|.|:.|...|.||||:|..              
Human   899 VCDFGFAVTAQVDERQHLS-------RIFISDVLPDGLAYGEGLRKGNEIM-------------- 942

  Fly   957 KYRADALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLER 1021
                          .|:.:.:||...|:.:.|.:   |:...:|.......|...:|:       
Human   943 --------------TLNGEAVSDLDLKQMEALFS---EKSVGLTLIARPPDTKATLCT------- 983

  Fly  1022 EYKREDDWCDGGGGSDKAQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGN 1086
                  .|.|    ||       |.|:.|                 ::.|...|:||...::..|
Human   984 ------SWSD----SD-------LFSRDQ-----------------KSLLPPPNQSQLLEEFLDN 1014

  Fly  1087 CEGHVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLV 1151
                                                  |::          ||...:.:......
Human  1015 --------------------------------------FKK----------NTANDFSNVPDITT 1031

  Fly  1152 GISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQRYKDFSN 1216
            |:.:.:|:|.|                                             ||       
Human  1032 GLKRSQTDGTL---------------------------------------------DQ------- 1044

  Fly  1217 RMDSYCEQLEKSLGMSQQ-QLLLGSDGNSSISSSSGDR-HSDP---TLEAKLNSSNKENKEINEE 1276
              .|:.|::|::...::| ..|..|..:|..:...|.| :.||   :|...|:.:::..|     
Human  1045 --VSHREKMEQTFRSAEQITALCRSFNDSQANGMEGPRENQDPPPRSLARHLSDADRLRK----- 1102

  Fly  1277 KRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDV--IFGNIKEIHH 1339
                      ::.||:.||::||.||:...:.:||..:     ....:.|:::  :||::.|:..
Human  1103 ----------VIQELVDTEKSYVKDLSCLFELYLEPLQ-----NETFLTQDEMESLFGSLPEMLE 1152

  Fly  1340 FHQKIFLRELE----------------KYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLV 1388
            | ||:||..||                ::..:...:|..|:.:|..|.:|..:|     :|::.|
Human  1153 F-QKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFC-----ANHIKV 1211

  Fly  1389 QHGGSFFEELQRR---------LEVDHP-------LPAYLIKPVQRITKYQLLLKDLLSCCE--- 1434
            |      :.|:|.         |:..:|       |.:||||||||:.||.||||:|:|..:   
Human  1212 Q------KVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQES 1270

  Fly  1435 ESHGEIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKL----------------GEVVLQDAFQ 1483
            |.|..:.|.|:.|..|....|:..  .:.|:.....|:|                ||:::.... 
Human  1271 EEHYHLTEALKAMEKVASHINEMQ--KIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTV- 1332

  Fly  1484 AWDTKQI----IRKGRERRVFLFE--LYLLFAKEVKESNVVKYQFKSKLMTTDMGITEHIEGDET 1542
            :|....:    .||..|..||:|:  :.|::.:..|        .|.||.:.........:.|..
Human  1333 SWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCK--------LKKKLPSNSRPAHNSTDLDPF 1389

  Fly  1543 KF----------------------AVW---------TGRSPMLSDCRIVLKATSLETKQIWVKKL 1576
            ||                      ::|         .||...:    ..|..:..|:|...||.:
Human  1390 KFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETI----FQLCCSDSESKTNIVKVI 1450

  Fly  1577 REVMQET------CFSGTSLTLPKS------PAKHS---GSSQRSSRDLDEQLTENDHDRCSLAS 1626
            |.:::|.      |    .|.|.|:      |.|:.   .:...|||.|  ::.:|.........
Human  1451 RSILRENFRRHIKC----ELPLEKTCKDRLVPLKNRVPVSAKLASSRSL--KVLKNSSSNEWTGE 1509

  Fly  1627 FGSGNTTDSDN---KLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFC--LVR- 1685
            .|.|...|||.   ..|.|.:....|:    ...:..|.|.|:.      |..|..||.  |:: 
Human  1510 TGKGTLLDSDEGSLSSGTQSSGCPTAE----GRQDSKSTSPGKY------PHPGLADFADNLIKE 1564

  Fly  1686 ---LNPQHDD--AAVQEGLVPVSV--------LKPPPGSHKHGS---GTAANAASSAGSQKSDMQ 1734
               |:.:.||  ..|::|.....:        :...|..|....   |..:......|.|...::
Human  1565 SDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPESGEGQKGGEQPKLVR 1629

  Fly  1735 DQSNRSKADALSSSTKR-RG 1753
            ......|..|  :|||| ||
Human  1630 GHFCPIKRKA--NSTKRDRG 1647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706 12/47 (26%)
SPEC 314..>468 CDD:238103 25/154 (16%)
SPEC 563..778 CDD:238103 43/269 (16%)
SPEC 782..997 CDD:238103 40/220 (18%)
SPEC 897..1119 CDD:238103 37/227 (16%)
SPEC 1125..1226 CDD:197544 11/100 (11%)
RhoGEF 1287..1455 CDD:459876 57/204 (28%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 30/180 (17%)
SH3_Kalirin_1 1643..1707 CDD:212786 14/79 (18%)
RhoGEF 1945..2121 CDD:459876
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
TIAM2NP_036586.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..250
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 265..293 3/8 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 389..417 6/27 (22%)
PH1_Tiam1_2 505..631 CDD:269937 46/239 (19%)
Tiam_CC_Ex 645..742 CDD:408184 25/153 (16%)
Ubl1_cv_Nsp3_N-like 811..881 CDD:475130 15/110 (14%)
PDZ 887..976 CDD:214570 24/127 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1070..1092 6/21 (29%)
RhoGEF 1103..1292 CDD:214619 57/205 (28%)
PH2_Tiam1_2 1294..1466 CDD:269957 31/190 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1500..1556 14/65 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1568..1628 10/59 (17%)
Blue background indicates that the domain is not in the aligned region.

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